N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Adachi T et al. | Membrane microdomain formation is crucial in epiboly during gastrulation of medaka. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17511962 |
Wang J et al. | Mechanisms involved in ceramide-induced cell cycle arrest in human hepatocarcinoma cells. | 2007 | World J. Gastroenterol. | pmid:17373752 |
Zhang J et al. | Impaired Fas-induced apoptosis of T lymphocytes in patients with abdominal aortic aneurysms. | 2007 | J. Vasc. Surg. | pmid:17350784 |
Van Overloop H et al. | On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. | 2007 | Biol. Chem. | pmid:17338639 |
Zhang TH et al. | Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinases. | 2007 | Acta Pharmacol. Sin. | pmid:17303009 |
Gibanova NV et al. | Protective effect of the hexapeptide TGENHR on the TNF-induced death of HL-60 cells. | 2006 Sep-Oct | Dokl. Biochem. Biophys. | pmid:17286111 |
JeBailey L et al. | Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells. | 2007 | Diabetes | pmid:17259384 |
MacRae VE et al. | Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent. | 2006 | J. Endocrinol. | pmid:17088406 |
Schumacher AM et al. | Death-associated protein kinase phosphorylates mammalian ribosomal protein S6 and reduces protein synthesis. | 2006 | Biochemistry | pmid:17087515 |
Zhang XF et al. | [Effect of ceramide on apoptosis of human colon cancer HT-29 cells]. | 2006 | Wei Sheng Yan Jiu | pmid:17086696 |
Wang J et al. | Ceramide induces apoptosis via a peroxisome proliferator-activated receptor gamma-dependent pathway. | 2006 | Apoptosis | pmid:17036198 |
Stoeck A et al. | L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. | 2007 | Gynecol. Oncol. | pmid:17030349 |
Aubert N et al. | PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway: involvement of c-Fos in PACAP-induced Bcl-2 expression. | 2006 | J. Neurochem. | pmid:17026529 |
Ghering AB and Davidson WS | Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I. | 2006 | J. Lipid Res. | pmid:16990644 |
Rath GM et al. | Thrombospondin-1 C-terminal-derived peptide protects thyroid cells from ceramide-induced apoptosis through the adenylyl cyclase pathway. | 2006 | Int. J. Biochem. Cell Biol. | pmid:16971166 |
Strle K et al. | C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts. | 2006 | Endocrinology | pmid:16777978 |
Tabarean IV et al. | Interleukin-1beta induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons. | 2006 | Neuroscience | pmid:16777343 |
Zhang XF et al. | Apoptosis of human colon carcinoma HT-29 cells induced by ceramide. | 2006 | World J. Gastroenterol. | pmid:16773715 |
Xin M and Deng X | Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation. | 2006 | J. Biol. Chem. | pmid:16679323 |
German OL et al. | Ceramide is a mediator of apoptosis in retina photoreceptors. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:16565407 |
Chen S et al. | Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes. | 2006 | J. Neurochem. | pmid:16524368 |
Kniep B et al. | 9-O-acetyl GD3 protects tumor cells from apoptosis. | 2006 | Int. J. Cancer | pmid:16432837 |
Kolettas E et al. | Bcl-2 but not clusterin/apolipoprotein J protected human diploid fibroblasts and immortalized keratinocytes from ceramide-induced apoptosis: role of p53 in the ceramide response. | 2006 | Arch. Biochem. Biophys. | pmid:16297852 |
Lecour S et al. | Ceramide-induced preconditioning involves reactive oxygen species. | 2006 | Life Sci. | pmid:16293265 |
Calatayud CA et al. | Involvement of the ubiquitin-mediated proteolytic system in the signaling pathway induced by ceramide in primary astrocyte cultures. | 2005 | Dev. Neurosci. | pmid:16280636 |
Bianchi K et al. | Regulation of Ca2+ signalling and Ca2+-mediated cell death by the transcriptional coactivator PGC-1alpha. | 2006 | Cell Death Differ. | pmid:16239931 |
Jang GJ et al. | C2-ceramide induces vasodilation in phenylephrine-induced pre-contracted rat thoracic aorta: role of RhoA/Rho-kinase and intracellular Ca2+ concentration. | 2005 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16231160 |
Woo KJ et al. | Bcl-2 attenuates anticancer agents-induced apoptosis by sustained activation of Akt/protein kinase B in U937 cells. | 2005 | Apoptosis | pmid:16215670 |
Takai N et al. | C2-ceramide exhibits antiproliferative activity and potently induces apoptosis in endometrial carcinoma. | 2005 | Oncol. Rep. | pmid:16211298 |
Sparkman L et al. | Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity. | 2006 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16183668 |
Hughes PJ et al. | Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. | 2006 | J. Cell. Biochem. | pmid:16178010 |
Falluel-Morel A et al. | [Effects of PACAP and C2-ceramide on motility of cerebellar granule neurons: the fastest is not the farthest]. | 2005 Aug-Sep | Med Sci (Paris) | pmid:16115451 |
Giltiay NV et al. | Ceramide- and ERK-dependent pathway for the activation of CCAAT/enhancer binding protein by interleukin-1beta in hepatocytes. | 2005 | J. Lipid Res. | pmid:16106045 |
Detre C et al. | Death or survival: membrane ceramide controls the fate and activation of antigen-specific T-cells depending on signal strength and duration. | 2006 | Cell. Signal. | pmid:16099142 |
Arboleda G et al. | Metabolic activity: a novel indicator of neuronal survival in the murine dopaminergic cell line CAD. | 2005 | J. Mol. Neurosci. | pmid:16055947 |
Goswami R et al. | Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines. | 2005 | J. Neurosci. Res. | pmid:15968641 |
Sot J et al. | Molecular associations and surface-active properties of short- and long-N-acyl chain ceramides. | 2005 | Biochim. Biophys. Acta | pmid:15904658 |
Kim SH et al. | Induction of apoptosis in chicken oviduct cells by C2-ceramide. | 2005 | Mol. Cells | pmid:15879700 |
Townley HE et al. | Ceramides induce programmed cell death in Arabidopsis cells in a calcium-dependent manner. | 2005 | Biol. Chem. | pmid:15843160 |
Gutwein P et al. | Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells. | 2005 | Clin. Cancer Res. | pmid:15814625 |
Jones EL et al. | The 70 kilodalton heat shock protein is an inhibitor of apoptosis in prostate cancer. | 2004 | Int J Hyperthermia | pmid:15764345 |
Yabu T et al. | Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate. | 2005 | Blood | pmid:15741222 |
Falluel-Morel A et al. | Pituitary adenylate cyclase-activating polypeptide prevents the effects of ceramides on migration, neurite outgrowth, and cytoskeleton remodeling. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15695581 |
Murase T et al. | Ceramide enhances acrosomal exocytosis triggered by calcium and the calcium ionophore A23187 in boar spermatozoa. | 2004 | J. Reprod. Dev. | pmid:15647619 |
Hampel B et al. | Differential regulation of apoptotic cell death in senescent human cells. | 2004 Nov-Dec | Exp. Gerontol. | pmid:15582287 |
Falluel-Morel A et al. | Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and PACAP through a MAP-kinase-dependent mechanism in cerebellar granule cells. | 2004 | J. Neurochem. | pmid:15569266 |
Park HW et al. | Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells. | 2004 | Exp. Mol. Med. | pmid:15557813 |
Hayashi M et al. | High sensitivity of fibroblast cell lines derived from LEC rats to heat treatment. | 2004 | J. Vet. Med. Sci. | pmid:15528845 |
Yao N et al. | The mitochondrion--an organelle commonly involved in programmed cell death in Arabidopsis thaliana. | 2004 | Plant J. | pmid:15500474 |
Cao LC et al. | Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity. | 2004 | Kidney Int. | pmid:15496160 |
d'Anglemont de Tassigny A et al. | Volume-sensitive chloride channels (ICl,vol) mediate doxorubicin-induced apoptosis through apoptotic volume decrease in cardiomyocytes. | 2004 | Fundam Clin Pharmacol | pmid:15482374 |
Ito Y et al. | Reduction of airway anion secretion via CFTR in sphingomyelin pathway. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15474513 |
Kawano Y et al. | Synergistic effect of interleukin (IL)-1alpha and ceramide analogue on the production of IL-6, IL-8, and macrophage colony-stimulating factor by endometrial stromal cells. | 2004 | Fertil. Steril. | pmid:15474071 |
Suzuki E et al. | Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15466700 |
Hida A et al. | Nitric oxide acts on the mitochondria and protects human endothelial cells from apoptosis. | 2004 | J. Lab. Clin. Med. | pmid:15454884 |
Jaiswal AS and Narayan S | Reduced levels of the adenomatous polyposis coli (APC) protein are associated with ceramide-induced apoptosis of colon cancer cells. | 2004 | J. Cancer Res. Clin. Oncol. | pmid:15340841 |
Park IN et al. | Ceramide, an apoptotic rheostat, inhibits CCAAT/enhancer binding protein-beta and NF-E2-related factor-2 activation: the role in glutathione S-transferase A2 gene repression. | 2004 | Drug Metab. Dispos. | pmid:15319326 |
Blázquez C et al. | Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. | 2004 | Cancer Res. | pmid:15313899 |
Hatano M et al. | Enhancement of C2-ceramide antitumor activity by small interfering RNA on X chromosome-linked inhibitor of apoptosis protein in resistant human glioma cells. | 2004 | J. Neurosurg. | pmid:15255262 |
Perks CM et al. | Prolactin acts as a potent survival factor for human breast cancer cell lines. | 2004 | Br. J. Cancer | pmid:15213724 |
Daido S et al. | Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. | 2004 | Cancer Res. | pmid:15205343 |
Dawson G et al. | Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death. | 2004 | J. Neurochem. | pmid:15189346 |
Schultz A and Larsson C | Ceramide influences neurite outgrowth and neuroblastoma cell apoptosis regulated by novel protein kinase C isoforms. | 2004 | J. Neurochem. | pmid:15189345 |
Park IN et al. | Ceramide negatively regulates glutathione S-transferase gene transactivation via repression of hepatic nuclear factor-1 that is degraded by the ubiquitin proteasome system. | 2004 | Mol. Pharmacol. | pmid:15155840 |
Pilane CM and LaBelle EF | NO induced apoptosis of vascular smooth muscle cells accompanied by ceramide increase. | 2004 | J. Cell. Physiol. | pmid:15040013 |
Shayman JA et al. | A turn in the road: How studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A2 with ceramide transacylase activity. | 2004 | Glycoconj. J. | pmid:14973367 |
Fernandez S et al. | Inhibition of IL-10 receptor function in alveolar macrophages by Toll-like receptor agonists. | 2004 | J. Immunol. | pmid:14764735 |
Kiss Z and Deli E | Regulation of phospholipase D by sphingosine involves both protein kinase C-dependent and -independent mechanisms in NIH 3T3 fibroblasts. | 1992 | Biochem. J. | pmid:1472000 |
Pascual M et al. | Ceramide pathways modulate ethanol-induced cell death in astrocytes. | 2003 | J. Neurochem. | pmid:14713309 |
Niiro H et al. | (3Z)-2-Acetylamino-3-octadecen-1-ol as a potent apoptotic agent against HL-60 cells. | 2004 | Bioorg. Med. Chem. | pmid:14697769 |
Gentil B et al. | Commitment to apoptosis by ceramides depends on mitochondrial respiratory function, cytochrome c release and caspase-3 activation in Hep-G2 cells. | 2003 | Mol. Cell. Biochem. | pmid:14674699 |
Perks CM et al. | Prolactin acts as a potent survival factor against C2-ceramide-induced apoptosis in human granulosa cells. | 2003 | Hum. Reprod. | pmid:14645190 |
Mansfield PJ et al. | Ceramide inhibition of phospholipase D and its relationship to RhoA and ARF1 translocation in GTP gamma S-stimulated polymorphonuclear leukocytes. | 2004 | Blood | pmid:14615385 |
Enomoto A et al. | Decreased c-Myc expression and its involvement in X-ray-induced apoptotic cell death of human T-cell leukaemia cell line MOLT-4. | 2003 | Int. J. Radiat. Biol. | pmid:14555342 |
Siskind LJ et al. | Enlargement and contracture of C2-ceramide channels. | 2003 | Biophys. J. | pmid:12944273 |
Amati F et al. | Analysis of intracellular distribution and apoptosis involvement of the Ufd1l gene product by over-expression studies. | 2003 | Cell Biochem. Funct. | pmid:12910480 |
Cotteret S et al. | p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. | 2003 | Mol. Cell. Biol. | pmid:12897128 |
Witting SR et al. | Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1. | 2003 | J. Biol. Chem. | pmid:12890677 |
Ramos B et al. | Prevalence of necrosis in C2-ceramide-induced cytotoxicity in NB16 neuroblastoma cells. | 2003 | Mol. Pharmacol. | pmid:12869656 |
Sreenivasan Y et al. | Mechanism of cytosine arabinoside-mediated apoptosis: role of Rel A (p65) dephosphorylation. | 2003 | Oncogene | pmid:12853972 |
Koide N et al. | C2-ceramide inhibits LPS-induced nitric oxide production in RAW 264.7 macrophage cells through down-regulating the activation of Akt. | 2003 | J. Endotoxin Res. | pmid:12803880 |
Shikata K et al. | Apoptotic activities of C2-ceramide and C2-dihydroceramide homologues against HL-60 cells. | 2003 | Bioorg. Med. Chem. | pmid:12788346 |
Hunsperger EA and Wilcox CL | Caspase-3-dependent reactivation of latent herpes simplex virus type 1 in sensory neuronal cultures. | 2003 | J. Neurovirol. | pmid:12775421 |
Willaime-Morawek S et al. | C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis. | 2003 | Neuroscience | pmid:12770554 |
Fillet M et al. | Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity. | 2003 | Biochem. Pharmacol. | pmid:12754099 |
Yakushiji K et al. | Characterization of C2-ceramide-resistant HL-60 subline (HL-CR): involvement of PKC delta in C2-ceramide resistance. | 2003 | Exp. Cell Res. | pmid:12749866 |
Liu SJ and Kennedy RH | Positive inotropic effect of ceramide in adult ventricular myocytes: mechanisms dissociated from its reduction in Ca2+ influx. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12730052 |
Stoica BA et al. | Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway. | 2003 | Mol. Cell. Neurosci. | pmid:12691738 |
Wang XQ et al. | Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress. | 2003 | J. Cell. Sci. | pmid:12679386 |
Kong JY and Rabkin SW | Mitochondrial effects with ceramide-induced cardiac apoptosis are different from those of palmitate. | 2003 | Arch. Biochem. Biophys. | pmid:12667483 |
Colligan PB et al. | Ceramide attenuates high glucose-induced cardiac contractile abnormalities in cultured adult rat ventricular myocytes. | 2002 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:12643441 |
Shack S et al. | Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. | 2003 | Mol. Cell. Biol. | pmid:12640124 |
Shikata K et al. | Synthesis of non-natural C2-homo-ceramide and its apoptotic activity against HL-60 cells. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12639542 |
Scorrano L et al. | BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. | 2003 | Science | pmid:12624178 |
Mikati MA et al. | Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms. | 2003 | Epilepsia | pmid:12614382 |
Upham BL et al. | Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis. | 2003 | Cancer Lett. | pmid:12609706 |
Cho YH et al. | Potentiation of lipopolysaccharide-inducible cyclooxygenase 2 expression by C2-ceramide via c-Jun N-terminal kinase-mediated activation of CCAAT/enhancer binding protein beta in macrophages. | 2003 | Mol. Pharmacol. | pmid:12606757 |
Maedler K et al. | Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. | 2003 | Diabetes | pmid:12606514 |
Ito M | Insulin or bFGF and C2 ceramide increase newborn rat retinal ganglion cell survival rate. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12565900 |
Darios F et al. | Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death. | 2003 | J. Neurochem. | pmid:12562509 |