N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Zinda MJ et al. | Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11162641 |
Adachi T et al. | Membrane microdomain formation is crucial in epiboly during gastrulation of medaka. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17511962 |
Ghosh Choudhury G et al. | Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11527425 |
Ito Y et al. | Reduction of airway anion secretion via CFTR in sphingomyelin pathway. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15474513 |
Sabatini M et al. | Effects of ceramide on aggrecanase activity in rabbit articular cartilage. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11355886 |
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Di Bartolomeo S et al. | Differential apoptotic effect and metabolism of N-acetylsphingosine and N-hexanoylsphingosine in CHP-100 human neurotumor cells. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25656578 |
Ito M | Insulin or bFGF and C2 ceramide increase newborn rat retinal ganglion cell survival rate. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12565900 |
Movsesyan VA et al. | Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12437970 |
Sabatini M et al. | Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10623638 |
Tanabe F et al. | Ceramide promotes calpain-mediated proteolysis of protein kinase C beta in murine polymorphonuclear leukocytes. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9439623 |
Mihai R et al. | C2-Ceramide increases cytoplasmic calcium concentrations in human parathyroid cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10679256 |
Migita K et al. | Regulation of rheumatoid synovial cell growth by ceramide. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10694479 |
Liu R et al. | Effects of sphingosine derivatives on MC3T3-E1 pre-osteoblasts: psychosine elicits release of calcium from intracellualr stores. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7677781 |
Buisson-Legendre N et al. | Involvement of the 92-kDa gelatinase (matrix metalloproteinase-9) in the ceramide-mediated inhibition of human keratinocyte growth. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10403818 |
Shinkai M et al. | Inhibitory action of sphingosine or ceramide on amylase secretion from isolated rat pancreatic acini. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9196062 |
Ferrari D et al. | Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19941832 |
Cheng YL et al. | Increased galectin-3 facilitates leukemia cell survival from apoptotic stimuli. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21821001 |
Xu FY et al. | N-Acetylsphingosine stimulates phosphatidylglycerolphosphate synthase activity in H9c2 cardiac cells. | 1999 | Biochem. J. | pmid:9895291 |