N-acetylsphingosine
N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
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Introduction
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with N-acetylsphingosine?
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
PubChem Associated disorders and diseases
What pathways are associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with N-acetylsphingosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with N-acetylsphingosine?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with N-acetylsphingosine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li H et al. | Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway. | 2013 | Cell Death Dis | pmid:24091673 |
| Cheng S et al. | Filopodial behavior is dependent on the phosphorylation state of neuronal growth cones. | 2000 | Cell Motil. Cytoskeleton | pmid:11093253 |
| Kumar Mangalam A et al. | Gold sodium thiomalate (GSTM) inhibits lipopolysaccharide stimulated tumor necrosis factor-alpha through ceramide pathway. | 2002 | Cell. Immunol. | pmid:12473262 |
| Pfau JC et al. | A comparison of the effects of lipopolysaccharide and ceramide on arachidonic acid metabolism in THP-1 monocytic cells. | 1998 | Cell. Immunol. | pmid:9665757 |
| Hershberger PA et al. | In vitro thymocyte maturation is associated with reduced cellular susceptibility to Fas-mediated apoptosis. | 1998 | Cell. Immunol. | pmid:9636691 |
| Colligan PB et al. | Ceramide attenuates high glucose-induced cardiac contractile abnormalities in cultured adult rat ventricular myocytes. | 2002 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:12643441 |
| Lauricella M et al. | Increased cyclin E level in retinoblastoma cells during programmed cell death. | 1998 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:9874510 |
| Jiang Z et al. | Ceramides induce apoptosis in HeLa cells and enhance cytochrome c-induced apoptosis in Xenopus egg extracts. | 2000 | Cell. Mol. Life Sci. | pmid:10961348 |
| Mora A et al. | Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A. | 2002 | Cell. Signal. | pmid:11897496 |
| Detre C et al. | Death or survival: membrane ceramide controls the fate and activation of antigen-specific T-cells depending on signal strength and duration. | 2006 | Cell. Signal. | pmid:16099142 |
| Shin CY et al. | C(2)-ceramide-induced circular smooth muscle cell contraction involves PKC-epsilon and p44/p42 MAPK activation in cat oesophagus. Mitogen-activated protein kinase. | 2002 | Cell. Signal. | pmid:12220618 |
| Hsieh CT et al. | Ceramide inhibits insulin-stimulated Akt phosphorylation through activation of Rheb/mTORC1/S6K signaling in skeletal muscle. | 2014 | Cell. Signal. | pmid:24650522 |
| Kim DS et al. | Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes. | 2002 | Cell. Signal. | pmid:12034359 |
| Kozawa O et al. | Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide. | 2002 | Cell. Signal. | pmid:12359305 |
| Shinoda J et al. | Effect of ceramide on interleukin-6 synthesis in osteoblast-like cells. | 1999 | Cell. Signal. | pmid:10400316 |
| Han J and Shin I | Ceramide does not inhibit protein kinase C beta-dependent phospholipase D activity stimulated by anti-Fas monoclonal antibody in A20 cells. | 2000 | Cell. Signal. | pmid:11152958 |
| Weil BR and Canty JM | Ceramide signaling in the coronary microcirculation: a double-edged sword? | 2014 | Circ. Res. | pmid:25124322 |
| Freed JK et al. | Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation. | 2014 | Circ. Res. | pmid:24920698 |
| Zhang DX et al. | Ceramide reduces endothelium-dependent vasodilation by increasing superoxide production in small bovine coronary arteries. | 2001 | Circ. Res. | pmid:11325875 |
| Gutwein P et al. | Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells. | 2005 | Clin. Cancer Res. | pmid:15814625 |
| Itoh M et al. | Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia. | 2003 | Clin. Cancer Res. | pmid:12538495 |
| Pignata C et al. | Clustering of distinct autoimmune diseases associated with functional abnormalities of T cell survival in children. | 2000 | Clin. Exp. Immunol. | pmid:10886239 |
| Kovács P et al. | Effect of C2 ceramide on the inositol phospholipid metabolism (uptake of 32P, 3H-serine and 3H-palmitic acid) and apoptosis-related morphological changes in Tetrahymena. | 1999 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:10190048 |
| Watton SJ and Downward J | Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction. | 1999 | Curr. Biol. | pmid:10226029 |
| Leanza L et al. | Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines. | 2014 | Curr. Pharm. Des. | pmid:23701546 |
| Kim YH and Kim SS | Increase of MnSOD expression and decrease of JNK activity determine the TNF sensitivity in bcl2-transfected L929 cells. | 1999 | Cytokine | pmid:10328866 |
| Campbell V and Lynch MA | The role of ceramide in the modulation of intracellular Ca2+ levels by interleukin 1 beta in rat cortical synaptosomes. | 2000 | Cytokine | pmid:10857764 |
| Connor CE et al. | Cell cycle arrest of hematopoietic cell lines after treatment with ceramide is commonly associated with retinoblastoma activation. | 2001 | Cytometry | pmid:11170101 |
| Calatayud CA et al. | Involvement of the ubiquitin-mediated proteolytic system in the signaling pathway induced by ceramide in primary astrocyte cultures. | 2005 | Dev. Neurosci. | pmid:16280636 |
| JeBailey L et al. | Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells. | 2007 | Diabetes | pmid:17259384 |
| Mei J et al. | C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes. | 2002 | Diabetes | pmid:11872660 |
| Maedler K et al. | Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. | 2003 | Diabetes | pmid:12606514 |
| Fontés G et al. | Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells. | 2009 | Diabetes | pmid:19502418 |
| Hajduch E et al. | Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. | 2001 | Diabetologia | pmid:11270673 |
| Gibanova NV et al. | Protective effect of the hexapeptide TGENHR on the TNF-induced death of HL-60 cells. | 2006 Sep-Oct | Dokl. Biochem. Biophys. | pmid:17286111 |
| Park IN et al. | Ceramide, an apoptotic rheostat, inhibits CCAAT/enhancer binding protein-beta and NF-E2-related factor-2 activation: the role in glutathione S-transferase A2 gene repression. | 2004 | Drug Metab. Dispos. | pmid:15319326 |
| Pacher P and Hajnóczky G | Propagation of the apoptotic signal by mitochondrial waves. | 2001 | EMBO J. | pmid:11483514 |
| Vitale N et al. | Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells. | 2001 | EMBO J. | pmid:11350931 |
| Pinton P et al. | The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. | 2001 | EMBO J. | pmid:11387204 |
| Marash M and Gerst JE | t-SNARE dephosphorylation promotes SNARE assembly and exocytosis in yeast. | 2001 | EMBO J. | pmid:11157748 |
| Gupta N et al. | Angiostatin effects on endothelial cells mediated by ceramide and RhoA. | 2001 | EMBO Rep. | pmid:11415988 |
| Kralik SF et al. | Ceramide and glucosamine antagonism of alternate signaling pathways regulating insulin- and osmotic shock-induced glucose transporter 4 translocation. | 2002 | Endocrinology | pmid:11751589 |
| Strle K et al. | C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts. | 2006 | Endocrinology | pmid:16777978 |
| Kaipia A et al. | Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles. | 1996 | Endocrinology | pmid:8895358 |
| Foghi A et al. | Fas-induced apoptosis in rat thecal/interstitial cells signals through sphingomyelin-ceramide pathway. | 1998 | Endocrinology | pmid:9528992 |
| Chae HJ et al. | Dexamethasone suppresses tumor necrosis factor-alpha-induced apoptosis in osteoblasts: possible role for ceramide. | 2000 | Endocrinology | pmid:10919278 |
| Maile LA et al. | The role of cell surface attachment and proteolysis in the insulin-like growth factor (IGF)-independent effects of IGF-binding protein-3 on apoptosis in breast epithelial cells. | 1999 | Endocrinology | pmid:10465274 |
| Mikati MA et al. | Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms. | 2003 | Epilepsia | pmid:12614382 |
| Lim JY et al. | Investigation on C2-ceramide complexes with transition metal ions using electrospray ionization tandem mass spectrometry. | 2008 | Eur J Mass Spectrom (Chichester, Eng) | pmid:18493098 |
| Monney L et al. | Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis. | 1998 | Eur. J. Biochem. | pmid:9492297 |