N-acetylsphingosine

N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.

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Introduction

To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with N-acetylsphingosine?

N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine

MeSH term MeSH ID Detail
Neuronal Ceroid-Lipofuscinoses D009472 5 associated lipids
Eye Abnormalities D005124 7 associated lipids
Retinoblastoma D012175 12 associated lipids
Helicobacter Infections D016481 21 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Medulloblastoma D008527 22 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Fever D005334 35 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Parkinson Disease D010300 53 associated lipids
Nerve Degeneration D009410 53 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Melanoma D008545 69 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Leukemia D007938 74 associated lipids
Arteriosclerosis D001161 86 associated lipids
Brain Ischemia D002545 89 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with N-acetylsphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with N-acetylsphingosine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with N-acetylsphingosine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with N-acetylsphingosine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with N-acetylsphingosine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with N-acetylsphingosine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with N-acetylsphingosine

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Authors Title Published Journal PubMed Link
Adachi T et al. Membrane microdomain formation is crucial in epiboly during gastrulation of medaka. 2007 Biochem. Biophys. Res. Commun. pmid:17511962
Ghosh Choudhury G et al. Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis. 2001 Biochem. Biophys. Res. Commun. pmid:11527425
Perks CM et al. A non-IGF binding mutant of IGFBP-3 modulates cell function in breast epithelial cells. 2002 Biochem. Biophys. Res. Commun. pmid:12074574
Perks CM et al. Effects of a non-IGF binding mutant of IGFBP-5 on cell death in human breast cancer cells. 2002 Biochem. Biophys. Res. Commun. pmid:12074575
Di Bartolomeo S et al. Differential apoptotic effect and metabolism of N-acetylsphingosine and N-hexanoylsphingosine in CHP-100 human neurotumor cells. 2015 Biochem. Biophys. Res. Commun. pmid:25656578
Kim HS et al. Induction of apoptosis by all-trans-retinoic acid and C2-ceramide treatment in rat stromal-vascular cultures. 2000 Biochem. Biophys. Res. Commun. pmid:10733907
Ito M Insulin or bFGF and C2 ceramide increase newborn rat retinal ganglion cell survival rate. 2003 Biochem. Biophys. Res. Commun. pmid:12565900
Movsesyan VA et al. Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway. 2002 Biochem. Biophys. Res. Commun. pmid:12437970
Tanabe F et al. Ceramide promotes calpain-mediated proteolysis of protein kinase C beta in murine polymorphonuclear leukocytes. 1998 Biochem. Biophys. Res. Commun. pmid:9439623
Migita K et al. Regulation of rheumatoid synovial cell growth by ceramide. 2000 Biochem. Biophys. Res. Commun. pmid:10694479