N-acetylsphingosine
N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
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Introduction
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with N-acetylsphingosine?
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
PubChem Associated disorders and diseases
What pathways are associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with N-acetylsphingosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with N-acetylsphingosine?
Related references are published most in these journals:
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What lipids are associated with N-acetylsphingosine?
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What genes are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with N-acetylsphingosine?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with N-acetylsphingosine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sugiki H et al. | C2-ceramide induces apoptosis in a human squamous cell carcinoma cell line. | 2000 | Br. J. Dermatol. | pmid:11122015 |
| Kimura M et al. | Release of plasminogen activator inhibitor-1 from human astrocytes is regulated by intracellular ceramide. | 2000 | J. Neurosci. Res. | pmid:11107162 |
| Cheng S et al. | Filopodial behavior is dependent on the phosphorylation state of neuronal growth cones. | 2000 | Cell Motil. Cytoskeleton | pmid:11093253 |
| Chen JS et al. | Regulation of phospholipase D activity and ceramide production in daunorubicin-induced apoptosis in A-431 cells. | 2000 | Biochim. Biophys. Acta | pmid:11082532 |
| Zhou H et al. | Akt regulates cell survival and apoptosis at a postmitochondrial level. | 2000 | J. Cell Biol. | pmid:11062251 |
| Ramos B et al. | Inhibition of phosphatidylcholine synthesis precedes apoptosis induced by C2-ceramide: protection by exogenous phosphatidylcholine. | 2000 | Neuroreport | pmid:11043531 |
| Navarro P et al. | Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. | 2000 | Growth Horm. IGF Res. | pmid:11042022 |
| Sautin Y et al. | Ceramide-induced apoptosis of human thyroid cancer cells resistant to apoptosis by irradiation. | 2000 | Thyroid | pmid:11041449 |
| Siskind LJ and Colombini M | The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosis. | 2000 | J. Biol. Chem. | pmid:11027675 |
| Klapisz E et al. | Sphingolipids and cholesterol modulate membrane susceptibility to cytosolic phospholipase A(2). | 2000 | J. Lipid Res. | pmid:11013311 |
| Müller-Wieprecht V et al. | Bcl-2 transfected HaCaT keratinocytes resist apoptotic signals of ceramides, tumor necrosis factor alpha and 1 alpha, 25-dihydroxyvitamin D(3). | 2000 | Arch. Dermatol. Res. | pmid:11000289 |
| Hirokawa M et al. | Induction of tissue factor production but not the upregulation of adhesion molecule expression by ceramide in human vascular endothelial cells. | 2000 | Tohoku J. Exp. Med. | pmid:10997557 |
| Pahlavani MA and Vargas DM | The effect of a ceramide analog, N-acetylsphingosine on the induction of proliferation and IL-2 synthesis in T cells from young and old F344 rats. | 2000 | Immunopharmacology | pmid:10996032 |
| Muriel MP et al. | Mitochondrial free calcium levels (Rhod-2 fluorescence) and ultrastructural alterations in neuronally differentiated PC12 cells during ceramide-dependent cell death. | 2000 | J. Comp. Neurol. | pmid:10982470 |
| Menné C et al. | Ceramide-induced TCR up-regulation. | 2000 | J. Immunol. | pmid:10975817 |
| Di Nardo A et al. | Ceramide 2 (N-acetyl sphingosine) is associated with reduction in Bcl-2 protein levels by Western blotting and with apoptosis in cultured human keratinocytes. | 2000 | Br. J. Dermatol. | pmid:10971319 |
| Jiang Z et al. | Ceramides induce apoptosis in HeLa cells and enhance cytochrome c-induced apoptosis in Xenopus egg extracts. | 2000 | Cell. Mol. Life Sci. | pmid:10961348 |
| Fukunaga T et al. | Implication of sphingolipid metabolism in the stability of the Golgi apparatus. | 2000 | J. Cell. Sci. | pmid:10954427 |
| Young KW et al. | Effect of dimethylsphingosine on muscarinic M(3) receptor signalling in SH-SY5Y cells. | 2000 | Eur. J. Pharmacol. | pmid:10940357 |
| Chae HJ et al. | Dexamethasone suppresses tumor necrosis factor-alpha-induced apoptosis in osteoblasts: possible role for ceramide. | 2000 | Endocrinology | pmid:10919278 |
| Allan D et al. | Mechanisms by which short-chain ceramides cause apoptosis. | 1999 | Biochem. Soc. Trans. | pmid:10917615 |
| O'Byrne D and Sansom D | Lack of costimulation by both sphingomyelinase and C2 ceramide in resting human T cells. | 2000 | Immunology | pmid:10886399 |
| Pignata C et al. | Clustering of distinct autoimmune diseases associated with functional abnormalities of T cell survival in children. | 2000 | Clin. Exp. Immunol. | pmid:10886239 |
| Campbell V and Lynch MA | The role of ceramide in the modulation of intracellular Ca2+ levels by interleukin 1 beta in rat cortical synaptosomes. | 2000 | Cytokine | pmid:10857764 |
| Posey SC et al. | Failure of gelsolin overexpression to regulate lymphocyte apoptosis. | 2000 | Blood | pmid:10828033 |
| Enomoto A et al. | Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human T-cell leukemia cell line MOLT-4. | 2000 | Cancer Lett. | pmid:10822128 |
| Knapp KM and English BK | Ceramide-mediated stimulation of inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation in murine macrophages requires tyrosine kinase activity. | 2000 | J. Leukoc. Biol. | pmid:10811015 |
| Chik CL et al. | Ceramide inhibits L-type calcium channel currents in rat pinealocytes. | 1999 | Adv. Exp. Med. Biol. | pmid:10810500 |
| Tavarini S et al. | Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells. | 2000 | Neurosci. Lett. | pmid:10806317 |
| Raisova M et al. | Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release. | 2000 | FEBS Lett. | pmid:10802053 |
| Meadows KA et al. | Tumor necrosis factor-alpha-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts. | 2000 | J. Cell. Physiol. | pmid:10797307 |
| De Nadai C et al. | Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10792026 |
| Takao N et al. | Protective roles for ATM in cellular response to oxidative stress. | 2000 | FEBS Lett. | pmid:10781820 |
| Tomita H et al. | Ceramide-induced cell death in cultured rat retinal pigment epithelial cells. | 2000 | Tohoku J. Exp. Med. | pmid:10778806 |
| Paolucci C et al. | Nitric oxide inhibits the tumor necrosis factor alpha -regulated endocytosis of human dendritic cells in a cyclic GMP-dependent way. | 2000 | J. Biol. Chem. | pmid:10777484 |
| Yeh MW et al. | Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l -cysteine. | 2000 | J. Immunol. | pmid:10754324 |
| Ahmed N and Berridge MV | Ceramides that mediate apoptosis reduce glucose uptake and transporter affinity for glucose in human leukaemic cell lines but not in neutrophils. | 2000 | Pharmacol. Toxicol. | pmid:10752668 |
| Brás A et al. | Ceramide-induced cell death is independent of the Fas/Fas ligand pathway and is prevented by Nur77 overexpression in A20 B cells. | 2000 | Cell Death Differ. | pmid:10745271 |
| Chan C and Goldkorn T | Ceramide path in human lung cell death. | 2000 | Am. J. Respir. Cell Mol. Biol. | pmid:10745027 |
| Cho S and Dawson G | Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells. | 2000 | J. Neurochem. | pmid:10737604 |
| Kim HS et al. | Induction of apoptosis by all-trans-retinoic acid and C2-ceramide treatment in rat stromal-vascular cultures. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10733907 |
| Kondo T et al. | Suppression of heat shock protein-70 by ceramide in heat shock-induced HL-60 cell apoptosis. | 2000 | J. Biol. Chem. | pmid:10722733 |
| Lobner D | Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis? | 2000 | J. Neurosci. Methods | pmid:10720679 |
| Dawson G | Mechanisms of apoptosis in embryonic cortical neurons (E6 and E7) in culture involve lipid signalling, protein phosphorylation and caspase activation. | 2000 Apr-Jun | Int. J. Dev. Neurosci. | pmid:10715579 |
| Galve-Roperh I et al. | Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. | 2000 | Nat. Med. | pmid:10700234 |
| Migita K et al. | Regulation of rheumatoid synovial cell growth by ceramide. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10694479 |
| Mihai R et al. | C2-Ceramide increases cytoplasmic calcium concentrations in human parathyroid cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10679256 |
| Tsushima H and Mori M | In vivo evidence that activation of tyrosine kinase is a trigger for lipopolysaccharide-induced fever in rats. | 2000 | Brain Res. | pmid:10678764 |
| Salinas M et al. | Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells. | 2000 | Mol. Cell. Neurosci. | pmid:10673324 |
| Kristal BS and Brown AM | Ganglioside GD3, the mitochondrial permeability transition, and apoptosis. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10672258 |
| Davis MA et al. | Effect of ceramide on intracellular glutathione determines apoptotic or necrotic cell death of JB6 tumor cells. | 2000 | Toxicol. Sci. | pmid:10653520 |
| Craighead M et al. | Caspases mediate C2-ceramide-induced apoptosis of the human oligodendroglial cell line, MO3.13. | 2000 | Neurosci. Lett. | pmid:10653009 |
| Liu J et al. | Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-alpha and ceramide. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10644522 |
| Allan D | Lipid metabolic changes caused by short-chain ceramides and the connection with apoptosis. | 2000 | Biochem. J. | pmid:10642519 |
| Micoli KJ et al. | Requirement of calmodulin binding by HIV-1 gp160 for enhanced FAS-mediated apoptosis. | 2000 | J. Biol. Chem. | pmid:10625668 |
| Sabatini M et al. | Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10623638 |
| Abend M et al. | Indications for an active process underlying spontaneous and radiation-induced micronucleation in L929 cells. | 1999 | Int. J. Radiat. Biol. | pmid:10622263 |
| Schürmann A et al. | p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. | 2000 | Mol. Cell. Biol. | pmid:10611223 |
| Susen K et al. | Nerve growth factor stimulates MAPK via the low affinity receptor p75(LNTR). | 1999 | FEBS Lett. | pmid:10606727 |
| Ogura M and Handa S | Induction of apoptosis by novel synthesized acylamides of human lymphocytes. | 2000 | Biochim. Biophys. Acta | pmid:10601700 |
| Ito A et al. | Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells. | 1999 | Biochim. Biophys. Acta | pmid:10590315 |
| Fujikawa K et al. | Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells. | 1999 | Exp. Cell Res. | pmid:10585289 |
| Zhang QH et al. | Redistribution of cytochrome c is not an essential requirement in C2-ceramide induced apoptosis in HL-60 cells. | 1999 | Life Sci. | pmid:10573189 |
| Ruiz L et al. | Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism. | 1999 | FEBS Lett. | pmid:10570948 |
| Shayman JA and Abe A | 1-O-acylceramide synthase. | 2000 | Meth. Enzymol. | pmid:10563315 |
| De Jonghe S et al. | Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10560744 |
| Park BJ et al. | Effect of ceramide on apoptosis and phospholipase D activity in FRTL-5 thyroid cells. | 1999 | Exp. Mol. Med. | pmid:10551263 |
| Olivera A et al. | Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. | 1999 | J. Cell Biol. | pmid:10545499 |
| Meroni SB et al. | Effect of N-acetylsphingosine (C2) and the ceramidase inhibitor (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol on the regulation of Sertoli cell function. | 1999 Sep-Oct | J. Androl. | pmid:10520574 |
| Pirianov G et al. | Potentiation by vitamin D analogs of TNFalpha and ceramide-induced apoptosis in MCF-7 cells is associated with activation of cytosolic phospholipase A2. | 1999 | Cell Death Differ. | pmid:10510471 |
| Askew DJ et al. | Characterization of Apt- cell lines exhibiting cross-resistance to glucocorticoid- and Fas-mediated apoptosis. | 1999 | Cell Death Differ. | pmid:10467354 |
| Belaud-Rotureau MA et al. | Ceramide-induced apoptosis occurs independently of caspases and is decreased by leupeptin. | 1999 | Cell Death Differ. | pmid:10467353 |
| Maile LA et al. | The role of cell surface attachment and proteolysis in the insulin-like growth factor (IGF)-independent effects of IGF-binding protein-3 on apoptosis in breast epithelial cells. | 1999 | Endocrinology | pmid:10465274 |
| Woessmann W et al. | An essential role for mitogen-activated protein kinases, ERKs, in preventing heat-induced cell death. | 1999 | J. Cell. Biochem. | pmid:10440934 |
| Scaffidi C et al. | Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. | 1999 | J. Biol. Chem. | pmid:10428830 |
| Yoshimura S et al. | Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death. | 1999 | J. Neurochem. | pmid:10428064 |
| Pahan K et al. | Induction of the manganese superoxide dismutase gene by sphingomyelinase and ceramide. | 1999 | J. Neurochem. | pmid:10428046 |
| Brindley DN et al. | Tumor necrosis factor-alpha and ceramides in insulin resistance. | 1999 | Lipids | pmid:10419100 |
| Buisson-Legendre N et al. | Involvement of the 92-kDa gelatinase (matrix metalloproteinase-9) in the ceramide-mediated inhibition of human keratinocyte growth. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10403818 |
| Shinoda J et al. | Effect of ceramide on interleukin-6 synthesis in osteoblast-like cells. | 1999 | Cell. Signal. | pmid:10400316 |
| Dallalio G et al. | Inhibition of human erythroid colony formation by ceramide. | 1999 | Exp. Hematol. | pmid:10390188 |
| Jones BE et al. | Ceramide induces caspase-independent apoptosis in rat hepatocytes sensitized by inhibition of RNA synthesis. | 1999 | Hepatology | pmid:10385659 |
| Stewart CE et al. | Increased, not decreased activation of the insulin-like growth factor (IGF) receptor signalling pathway during ceramide-induced apoptosis. | 1999 | Growth Horm. IGF Res. | pmid:10373346 |
| Li PL et al. | Effect of ceramide on KCa channel activity and vascular tone in coronary arteries. | 1999 | Hypertension | pmid:10373230 |
| Hisano N et al. | Induction and suppression of endothelial cell apoptosis by sphingolipids: a possible in vitro model for cell-cell interactions between platelets and endothelial cells. | 1999 | Blood | pmid:10361127 |
| Pruschy M et al. | Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells. | 1999 | Br. J. Cancer | pmid:10360645 |
| Masamune A et al. | Helicobacter pylori-dependent ceramide production may mediate increased interleukin 8 expression in human gastric cancer cell lines. | 1999 | Gastroenterology | pmid:10348816 |
| Taniwaki T et al. | Ceramide induces apoptosis to immature cerebellar granule cells in culture. | 1999 | Neurochem. Res. | pmid:10344598 |
| Mengubas K et al. | Killing of T lymphocytes by synthetic ceramide is by a nonapoptotic mechanism and is abrogated following mitogenic activation. | 1999 | Exp. Cell Res. | pmid:10328959 |
| Kim YH and Kim SS | Increase of MnSOD expression and decrease of JNK activity determine the TNF sensitivity in bcl2-transfected L929 cells. | 1999 | Cytokine | pmid:10328866 |
| Mengubas K et al. | Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism. | 1999 | Oncogene | pmid:10229201 |
| Watton SJ and Downward J | Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction. | 1999 | Curr. Biol. | pmid:10226029 |
| Herr I et al. | FK506 prevents stroke-induced generation of ceramide and apoptosis signaling. | 1999 | Brain Res. | pmid:10224298 |
| Lee BR and Um HD | Hydrogen peroxide suppresses U937 cell death by two different mechanisms depending on its concentration. | 1999 | Exp. Cell Res. | pmid:10222135 |
| Alesse E et al. | The growth arrest and downregulation of c-myc transcription induced by ceramide are related events dependent on p21 induction, Rb underphosphorylation and E2F sequestering. | 1998 | Cell Death Differ. | pmid:10200487 |
| Tolleson WH et al. | Fumonisin B1 induces apoptosis in cultured human keratinocytes through sphinganine accumulation and ceramide depletion. | 1999 | Int. J. Oncol. | pmid:10200332 |
| Su X et al. | Differential activation of phosphoinositide 3-kinase by endothelin and ceramide in colonic smooth muscle cells. | 1999 | Am. J. Physiol. | pmid:10198327 |
| Puranam KL et al. | CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide. | 1999 | Mol. Genet. Metab. | pmid:10191118 |
| Kovács P et al. | Effect of C2 ceramide on the inositol phospholipid metabolism (uptake of 32P, 3H-serine and 3H-palmitic acid) and apoptosis-related morphological changes in Tetrahymena. | 1999 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:10190048 |
| Blázquez C et al. | The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme. | 1999 | J. Neurochem. | pmid:10098887 |