N-acetylsphingosine
N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
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Introduction
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with N-acetylsphingosine?
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
PubChem Associated disorders and diseases
What pathways are associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with N-acetylsphingosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with N-acetylsphingosine?
Related references are published most in these journals:
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What lipids are associated with N-acetylsphingosine?
Related references are published most in these journals:
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What genes are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with N-acetylsphingosine?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with N-acetylsphingosine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Itakura A et al. | Ceramide and sphingosine rapidly induce apoptosis of murine mast cells supported by interleukin-3 and stem cell factor. | 2002 | Exp. Hematol. | pmid:11882365 |
| Kondo T et al. | Vesnarinone causes oxidative damage by inhibiting catalase function through ceramide action in myeloid cell apoptosis. | 2002 | Mol. Pharmacol. | pmid:11854443 |
| Shou J et al. | Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. | 2002 | Oncogene | pmid:11840333 |
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| Kralik SF et al. | Ceramide and glucosamine antagonism of alternate signaling pathways regulating insulin- and osmotic shock-induced glucose transporter 4 translocation. | 2002 | Endocrinology | pmid:11751589 |
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| Deng J et al. | Ceramide does not act as a general second messenger for ultraviolet-induced apoptosis. | 2002 | Oncogene | pmid:11791175 |
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| Phillips DC et al. | Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status. | 2002 | Arch. Biochem. Biophys. | pmid:12392710 |
| Hearps AC et al. | Mitochondrial cytochrome c release precedes transmembrane depolarisation and caspase-3 activation during ceramide-induced apoptosis of Jurkat T cells. | 2002 | Apoptosis | pmid:12207171 |
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| Kim HJ and Lee KJ | Heat shock and ceramide have different apoptotic pathways in radiation induced fibrosarcoma (RIF) cells. | 2002 | Mol. Cell. Biochem. | pmid:11936839 |
| Calcerrada MC et al. | Involvement of phosphatidylinositol 3-kinase in nuclear translocation of protein kinase C zeta induced by C2-ceramide in rat hepatocytes. | 2002 | FEBS Lett. | pmid:11943182 |
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| Perks CM et al. | A non-IGF binding mutant of IGFBP-3 modulates cell function in breast epithelial cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12074574 |
| Perks CM et al. | Effects of a non-IGF binding mutant of IGFBP-5 on cell death in human breast cancer cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12074575 |
| Mansfield PJ et al. | Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b(558) by gelatinase-granule release. | 2002 | J. Lab. Clin. Med. | pmid:12080323 |
| Kondo T et al. | Control of ceramide-induced apoptosis by IGF-1: involvement of PI-3 kinase, caspase-3 and catalase. | 2002 | Cell Death Differ. | pmid:12032677 |
| Sprott KM et al. | Decreased activity and enhanced nuclear export of CCAAT-enhancer-binding protein beta during inhibition of adipogenesis by ceramide. | 2002 | Biochem. J. | pmid:12071851 |
| Han WS et al. | Effects of C2-ceramide on the Malme-3M melanoma cell line. | 2002 | J. Dermatol. Sci. | pmid:12354415 |
| Zhang YH et al. | Ceramide, a putative second messenger for nerve growth factor, modulates the TTX-resistant Na(+) current and delayed rectifier K(+) current in rat sensory neurons. | 2002 | J. Physiol. (Lond.) | pmid:12381813 |
| Marques M et al. | Identification of platelet-activating factor acetylhydrolase II in human skin. | 2002 | J. Invest. Dermatol. | pmid:12406338 |
| Xiao AY et al. | Slight impairment of Na+,K+-ATPase synergistically aggravates ceramide- and beta-amyloid-induced apoptosis in cortical neurons. | 2002 | Brain Res. | pmid:12419544 |
| Shin CY et al. | C(2)-ceramide-induced circular smooth muscle cell contraction involves PKC-epsilon and p44/p42 MAPK activation in cat oesophagus. Mitogen-activated protein kinase. | 2002 | Cell. Signal. | pmid:12220618 |
| Kumar Mangalam A et al. | Gold sodium thiomalate (GSTM) inhibits lipopolysaccharide stimulated tumor necrosis factor-alpha through ceramide pathway. | 2002 | Cell. Immunol. | pmid:12473262 |
| Movsesyan VA et al. | Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12437970 |
| Rapizzi E et al. | Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria. | 2002 | J. Cell Biol. | pmid:12438411 |
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| Siskind LJ et al. | Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. | 2002 | J. Biol. Chem. | pmid:12006562 |
| Kim DS et al. | Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes. | 2002 | Cell. Signal. | pmid:12034359 |
| Preaux AM et al. | Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2. | 2002 | Hepatology | pmid:12198653 |
| Mallick S et al. | Human placental lipid induces mitogenesis and melanogenesis in B16F10 melanoma cells. | 2002 | J. Biosci. | pmid:12089473 |
| Kozawa O et al. | Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide. | 2002 | Cell. Signal. | pmid:12359305 |
| Shklyaev SS et al. | Involvement of wild-type p53 in radiation-induced c-Jun N-terminal kinase activation in human thyroid cells. | 2001 Jul-Aug | Anticancer Res. | pmid:11724323 |
| Ktitorova OV et al. | [Relationship between the induction of MDR1, a multidrug resistance gene in tumor cells, and apoptosis]. | 2001 Jul-Aug | Ontogenez | pmid:11573427 |
| Menné C et al. | T-cell receptor downregulation by ceramide-induced caspase activation and cleavage of the zeta chain. | 2001 | Scand. J. Immunol. | pmid:11169222 |
| Guidarelli A et al. | TNFalpha enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation. | 2001 | Exp. Cell Res. | pmid:11597127 |
| Vitale N et al. | Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells. | 2001 | EMBO J. | pmid:11350931 |
| Sabatini M et al. | Effects of ceramide on aggrecanase activity in rabbit articular cartilage. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11355886 |
| Connor CE et al. | Cell cycle arrest of hematopoietic cell lines after treatment with ceramide is commonly associated with retinoblastoma activation. | 2001 | Cytometry | pmid:11170101 |
| Chen Y et al. | The protective effect of ceramide in immature rat brain hypoxia-ischemia involves up-regulation of bcl-2 and reduction of TUNEL-positive cells. | 2001 | J. Cereb. Blood Flow Metab. | pmid:11149666 |
| Bulanova E et al. | The IL-15R alpha chain signals through association with Syk in human B cells. | 2001 | J. Immunol. | pmid:11714793 |