N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Conway EM et al. | Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways. | 2002 | Gastroenterology | pmid:12145814 |
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Todaro M et al. | High levels of exogenous C2-ceramide promote morphological and biochemical evidences of necrotic features in thyroid follicular cells. | 2002 | J. Cell. Biochem. | pmid:12112027 |
Hearps AC et al. | Mitochondrial cytochrome c release precedes transmembrane depolarisation and caspase-3 activation during ceramide-induced apoptosis of Jurkat T cells. | 2002 | Apoptosis | pmid:12207171 |
Gómez Del Pulgar T et al. | Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway. | 2002 | J. Biol. Chem. | pmid:12133838 |
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Mansfield PJ et al. | Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b(558) by gelatinase-granule release. | 2002 | J. Lab. Clin. Med. | pmid:12080323 |
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Sprott KM et al. | Decreased activity and enhanced nuclear export of CCAAT-enhancer-binding protein beta during inhibition of adipogenesis by ceramide. | 2002 | Biochem. J. | pmid:12071851 |
Han WS et al. | Effects of C2-ceramide on the Malme-3M melanoma cell line. | 2002 | J. Dermatol. Sci. | pmid:12354415 |
Kumar Mangalam A et al. | Gold sodium thiomalate (GSTM) inhibits lipopolysaccharide stimulated tumor necrosis factor-alpha through ceramide pathway. | 2002 | Cell. Immunol. | pmid:12473262 |
Movsesyan VA et al. | Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12437970 |
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Mallick S et al. | Human placental lipid induces mitogenesis and melanogenesis in B16F10 melanoma cells. | 2002 | J. Biosci. | pmid:12089473 |