N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Tan KB et al. | Liposomal codelivery of a synergistic combination of bioactive lipids in the treatment of acute myeloid leukemia. | 2014 | Nanomedicine (Lond) | pmid:24294981 |
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Chiu TT et al. | Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance. | 2013 | J. Biol. Chem. | pmid:23640896 |
Lee JT et al. | Homocysteine induces cerebral endothelial cell death by activating the acid sphingomyelinase ceramide pathway. | 2013 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:23665108 |
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Li H et al. | Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway. | 2013 | Cell Death Dis | pmid:24091673 |
Pacheco A et al. | C2-phytoceramide perturbs lipid rafts and cell integrity in Saccharomyces cerevisiae in a sterol-dependent manner. | 2013 | PLoS ONE | pmid:24040213 |
Guo L et al. | Sphingosine-1-phosphate inhibits ceramide-induced apoptosis during murine preimplantation embryonic development. | 2013 | Theriogenology | pmid:23731666 |
Dekker MJ et al. | Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction. | 2013 | Atherosclerosis | pmid:23466071 |
Zhang X et al. | Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis. | 2012 | Eur. J. Pharmacol. | pmid:22296759 |
Li R et al. | [Effect of ceramide on GSTA1 in Caco-2 cells]. | 2012 | Yao Xue Xue Bao | pmid:22993865 |
Sabirzhanov B et al. | Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis. | 2012 | J. Neurochem. | pmid:22909049 |
Sánchez-Mora RM et al. | PINK1 overexpression protects against C2-ceramide-induced CAD cell death through the PI3K/AKT pathway. | 2012 | J. Mol. Neurosci. | pmid:22212487 |
Li R et al. | Specific phosphorylation of αA-crystallin is required for the αA-crystallin-induced protection of astrocytes against staurosporine and C2-ceramide toxicity. | 2012 | Neurochem. Int. | pmid:22414529 |
Kim SK et al. | Palmitate induces RIP1-dependent necrosis in RAW 264.7 cells. | 2012 | Atherosclerosis | pmid:23084711 |
Taniguchi M et al. | Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway. | 2012 | J. Biol. Chem. | pmid:23035115 |
Kue CS et al. | C6-ceramide enhances Interleukin-12-mediated T helper type 1 cell responses through a cyclooxygenase-2-dependent pathway. | 2012 | Immunobiology | pmid:22112438 |