N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Kondo T et al. | Control of ceramide-induced apoptosis by IGF-1: involvement of PI-3 kinase, caspase-3 and catalase. | 2002 | Cell Death Differ. | pmid:12032677 |
Kim DS et al. | Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes. | 2002 | Cell. Signal. | pmid:12034359 |
Sprott KM et al. | Decreased activity and enhanced nuclear export of CCAAT-enhancer-binding protein beta during inhibition of adipogenesis by ceramide. | 2002 | Biochem. J. | pmid:12071851 |
Perks CM et al. | A non-IGF binding mutant of IGFBP-3 modulates cell function in breast epithelial cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12074574 |
Perks CM et al. | Effects of a non-IGF binding mutant of IGFBP-5 on cell death in human breast cancer cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12074575 |
Mansfield PJ et al. | Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b(558) by gelatinase-granule release. | 2002 | J. Lab. Clin. Med. | pmid:12080323 |
Mallick S et al. | Human placental lipid induces mitogenesis and melanogenesis in B16F10 melanoma cells. | 2002 | J. Biosci. | pmid:12089473 |
Toman RE et al. | Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis. | 2002 | J. Neurosci. Res. | pmid:12111862 |
Todaro M et al. | High levels of exogenous C2-ceramide promote morphological and biochemical evidences of necrotic features in thyroid follicular cells. | 2002 | J. Cell. Biochem. | pmid:12112027 |
Gómez Del Pulgar T et al. | Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway. | 2002 | J. Biol. Chem. | pmid:12133838 |
Conway EM et al. | Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways. | 2002 | Gastroenterology | pmid:12145814 |
Poppe M et al. | Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression. | 2002 | J. Neurochem. | pmid:12153473 |
Soltys CL et al. | Phosphorylation of cardiac protein kinase B is regulated by palmitate. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12181135 |
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Preaux AM et al. | Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2. | 2002 | Hepatology | pmid:12198653 |
Hearps AC et al. | Mitochondrial cytochrome c release precedes transmembrane depolarisation and caspase-3 activation during ceramide-induced apoptosis of Jurkat T cells. | 2002 | Apoptosis | pmid:12207171 |
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De Stefanis D et al. | Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells. | 2002 | Biol. Chem. | pmid:12222689 |
Han WS et al. | Effects of C2-ceramide on the Malme-3M melanoma cell line. | 2002 | J. Dermatol. Sci. | pmid:12354415 |
Kozawa O et al. | Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide. | 2002 | Cell. Signal. | pmid:12359305 |
Zhang YH et al. | Ceramide, a putative second messenger for nerve growth factor, modulates the TTX-resistant Na(+) current and delayed rectifier K(+) current in rat sensory neurons. | 2002 | J. Physiol. (Lond.) | pmid:12381813 |
Ramos B et al. | Inhibition of CTP:phosphocholine cytidylyltransferase by C(2)-ceramide and its relationship to apoptosis. | 2002 | Mol. Pharmacol. | pmid:12391269 |
Phillips DC et al. | Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status. | 2002 | Arch. Biochem. Biophys. | pmid:12392710 |
Marques M et al. | Identification of platelet-activating factor acetylhydrolase II in human skin. | 2002 | J. Invest. Dermatol. | pmid:12406338 |
Xiao AY et al. | Slight impairment of Na+,K+-ATPase synergistically aggravates ceramide- and beta-amyloid-induced apoptosis in cortical neurons. | 2002 | Brain Res. | pmid:12419544 |
Movsesyan VA et al. | Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12437970 |
Rapizzi E et al. | Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria. | 2002 | J. Cell Biol. | pmid:12438411 |