| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Eye Abnormalities | D005124 | 7 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Medulloblastoma | D008527 | 22 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Neuronal Ceroid-Lipofuscinoses | D009472 | 5 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Retinoblastoma | D012175 | 12 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
N-acetylsphingosine
N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
Cross Reference
Introduction
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with N-acetylsphingosine?
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
PubChem Associated disorders and diseases
What pathways are associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with N-acetylsphingosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with N-acetylsphingosine?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with N-acetylsphingosine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Cline HT and Constantine-Paton M | The differential influence of protein kinase inhibitors on retinal arbor morphology and eye-specific stripes in the frog retinotectal system. | 1990 | Neuron | pmid:2361013 |
| Pitto M et al. | Metabolism of semisynthetic single-chain GM1 derivatives in cerebellar granule cells in culture. | 1991 | Neurochem. Res. | pmid:1815134 |
| Kiss Z and Deli E | Regulation of phospholipase D by sphingosine involves both protein kinase C-dependent and -independent mechanisms in NIH 3T3 fibroblasts. | 1992 | Biochem. J. | pmid:1472000 |
| Ladenson RC et al. | Utilization of exogenously supplied sphingosine analogues for sphingolipid biosynthesis in Chinese hamster ovary and mouse LM cell fibroblasts. | 1993 | J. Biol. Chem. | pmid:8463295 |
| Wong K et al. | N-acetylsphingosine (C2-ceramide) inhibited neutrophil superoxide formation and calcium influx. | 1995 | J. Biol. Chem. | pmid:7852386 |
| Law B and Rossie S | The dimeric and catalytic subunit forms of protein phosphatase 2A from rat brain are stimulated by C2-ceramide. | 1995 | J. Biol. Chem. | pmid:7759536 |
| Ridgway ND | Inhibition of acyl-CoA:cholesterol acyltransferase in Chinese hamster ovary (CHO) cells by short-chain ceramide and dihydroceramide. | 1995 | Biochim. Biophys. Acta | pmid:7742354 |
| Jones MJ and Murray AW | Evidence that ceramide selectively inhibits protein kinase C-alpha translocation and modulates bradykinin activation of phospholipase D. | 1995 | J. Biol. Chem. | pmid:7890607 |
| Jäättelä M et al. | Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. | 1995 | Oncogene | pmid:7540278 |
| Sawai H et al. | Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells. | 1995 | J. Biol. Chem. | pmid:7592995 |
| Liu R et al. | Effects of sphingosine derivatives on MC3T3-E1 pre-osteoblasts: psychosine elicits release of calcium from intracellualr stores. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7677781 |
| Kiss Z and Deli E | Preferential inhibition of phorbol ester-induced hydrolysis of phosphatidylethanolamine by N-acetylsphingosine in NIH 3T3 fibroblasts. | 1995 | FEBS Lett. | pmid:7781767 |
| Verheij M et al. | Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. | 1996 | Nature | pmid:8598911 |
| Nickels JT and Broach JR | A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae. | 1996 | Genes Dev. | pmid:8600023 |
| Mizushima N et al. | Ceramide induces apoptosis via CPP32 activation. | 1996 | FEBS Lett. | pmid:8898109 |
| Kuroki J et al. | Cell-permeable ceramide inhibits the growth of B lymphoma Raji cells lacking TNF-alpha-receptors by inducing G0/G1 arrest but not apoptosis: a new model for dissecting cell-cycle arrest and apoptosis. | 1996 | Leukemia | pmid:8946936 |
| Kaipia A et al. | Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles. | 1996 | Endocrinology | pmid:8895358 |
| Chmura SJ et al. | Cross-talk between ceramide and PKC activity in the control of apoptosis in WEHI-231. | 1996 | Adv. Exp. Med. Biol. | pmid:8910670 |
| Metz RJ et al. | Vitamin D3 and ceramide reduce the invasion of tumor cells through extracellular matrix components by elevating protein phosphatase-2A. | 1996 | Invasion Metastasis | pmid:9371227 |