N-acetylsphingosine

N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.

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Introduction

To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with N-acetylsphingosine?

N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine

MeSH term MeSH ID Detail
Arteriosclerosis D001161 86 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Eye Abnormalities D005124 7 associated lipids
Fever D005334 35 associated lipids
Glioma D005910 112 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Insulin Resistance D007333 99 associated lipids
Leukemia D007938 74 associated lipids
Lung Neoplasms D008175 171 associated lipids
Medulloblastoma D008527 22 associated lipids
Melanoma D008545 69 associated lipids
Nerve Degeneration D009410 53 associated lipids
Neuronal Ceroid-Lipofuscinoses D009472 5 associated lipids
Parkinson Disease D010300 53 associated lipids
Retinoblastoma D012175 12 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with N-acetylsphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with N-acetylsphingosine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with N-acetylsphingosine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with N-acetylsphingosine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with N-acetylsphingosine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with N-acetylsphingosine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with N-acetylsphingosine

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Authors Title Published Journal PubMed Link
De Jonghe S et al. Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues. 1999 Bioorg. Med. Chem. Lett. pmid:10560744
Susen K et al. Nerve growth factor stimulates MAPK via the low affinity receptor p75(LNTR). 1999 FEBS Lett. pmid:10606727
Ruiz L et al. Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism. 1999 FEBS Lett. pmid:10570948
Zhang QH et al. Redistribution of cytochrome c is not an essential requirement in C2-ceramide induced apoptosis in HL-60 cells. 1999 Life Sci. pmid:10573189
Allan D et al. Mechanisms by which short-chain ceramides cause apoptosis. 1999 Biochem. Soc. Trans. pmid:10917615
Xu FY et al. N-Acetylsphingosine stimulates phosphatidylglycerolphosphate synthase activity in H9c2 cardiac cells. 1999 Biochem. J. pmid:9895291
Puranam KL et al. CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide. 1999 Mol. Genet. Metab. pmid:10191118
Su X et al. Differential activation of phosphoinositide 3-kinase by endothelin and ceramide in colonic smooth muscle cells. 1999 Am. J. Physiol. pmid:10198327
Kovács P et al. Effect of C2 ceramide on the inositol phospholipid metabolism (uptake of 32P, 3H-serine and 3H-palmitic acid) and apoptosis-related morphological changes in Tetrahymena. 1999 Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. pmid:10190048
Maile LA et al. The role of cell surface attachment and proteolysis in the insulin-like growth factor (IGF)-independent effects of IGF-binding protein-3 on apoptosis in breast epithelial cells. 1999 Endocrinology pmid:10465274