N-acetylsphingosine

N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.

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Introduction

To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with N-acetylsphingosine?

N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine

MeSH term MeSH ID Detail
Arteriosclerosis D001161 86 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Eye Abnormalities D005124 7 associated lipids
Fever D005334 35 associated lipids
Glioma D005910 112 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Insulin Resistance D007333 99 associated lipids
Leukemia D007938 74 associated lipids
Lung Neoplasms D008175 171 associated lipids
Medulloblastoma D008527 22 associated lipids
Melanoma D008545 69 associated lipids
Nerve Degeneration D009410 53 associated lipids
Neuronal Ceroid-Lipofuscinoses D009472 5 associated lipids
Parkinson Disease D010300 53 associated lipids
Retinoblastoma D012175 12 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with N-acetylsphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with N-acetylsphingosine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with N-acetylsphingosine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with N-acetylsphingosine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with N-acetylsphingosine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with N-acetylsphingosine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with N-acetylsphingosine

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Authors Title Published Journal PubMed Link
Rossner S et al. p75 and TrkA receptor signaling independently regulate amyloid precursor protein mRNA expression, isoform composition, and protein secretion in PC12 cells. 1998 J. Neurochem. pmid:9681467
Johns DG et al. The role of the endothelium in ceramide-induced vasodilation. 1998 Eur. J. Pharmacol. pmid:9671089
Pfau JC et al. A comparison of the effects of lipopolysaccharide and ceramide on arachidonic acid metabolism in THP-1 monocytic cells. 1998 Cell. Immunol. pmid:9665757
Hartfield PJ et al. Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells. 1998 J. Neurochem. pmid:9648862
Hershberger PA et al. In vitro thymocyte maturation is associated with reduced cellular susceptibility to Fas-mediated apoptosis. 1998 Cell. Immunol. pmid:9636691
Zhou H et al. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. 1998 J. Biol. Chem. pmid:9632728
Boland MP and O'Neill LA Ceramide activates NFkappaB by inducing the processing of p105. 1998 J. Biol. Chem. pmid:9624136
Ichinose Y et al. Apoptosis induction in synovial fibroblasts by ceramide: in vitro and in vivo effects. 1998 J. Lab. Clin. Med. pmid:9605105
Durrieu F et al. Caspase activation is an early event in anthracycline-induced apoptosis and allows detection of apoptotic cells before they are ingested by phagocytes. 1998 Exp. Cell Res. pmid:9596989
Canova C et al. Epigenetic control of programmed cell death: inhibition by 5-azacytidine of 1,25-dihydroxyvitamin D3-induced programmed cell death in C6.9 glioma cells. 1998 Mech. Ageing Dev. pmid:9593321