N-acetylsphingosine

N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.

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Introduction

To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with N-acetylsphingosine?

N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine

MeSH term MeSH ID Detail
Arteriosclerosis D001161 86 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Eye Abnormalities D005124 7 associated lipids
Fever D005334 35 associated lipids
Glioma D005910 112 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Insulin Resistance D007333 99 associated lipids
Leukemia D007938 74 associated lipids
Lung Neoplasms D008175 171 associated lipids
Medulloblastoma D008527 22 associated lipids
Melanoma D008545 69 associated lipids
Nerve Degeneration D009410 53 associated lipids
Neuronal Ceroid-Lipofuscinoses D009472 5 associated lipids
Parkinson Disease D010300 53 associated lipids
Retinoblastoma D012175 12 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with N-acetylsphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with N-acetylsphingosine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with N-acetylsphingosine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with N-acetylsphingosine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with N-acetylsphingosine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with N-acetylsphingosine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with N-acetylsphingosine

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Authors Title Published Journal PubMed Link
Cabrero A et al. Uncoupling protein-3 mRNA up-regulation in C2C12 myotubes after etomoxir treatment. 2001 Biochim. Biophys. Acta pmid:11470240
Wehinger S et al. Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells. 2015 Biochim. Biophys. Acta pmid:25572853
Ridgway ND Inhibition of acyl-CoA:cholesterol acyltransferase in Chinese hamster ovary (CHO) cells by short-chain ceramide and dihydroceramide. 1995 Biochim. Biophys. Acta pmid:7742354
Ito A et al. Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells. 1999 Biochim. Biophys. Acta pmid:10590315
Kishida E et al. Distinctive inhibitory activity of docosahexaenoic acid against sphingosine-induced apoptosis. 1998 Biochim. Biophys. Acta pmid:9555103
Sot J et al. Molecular associations and surface-active properties of short- and long-N-acyl chain ceramides. 2005 Biochim. Biophys. Acta pmid:15904658
El Btaouri H et al. Role of JNK/ATF-2 pathway in inhibition of thrombospondin-1 (TSP-1) expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells. 2011 Biochim. Biophys. Acta pmid:21333695
Chen JS et al. Regulation of phospholipase D activity and ceramide production in daunorubicin-induced apoptosis in A-431 cells. 2000 Biochim. Biophys. Acta pmid:11082532
Soeda S et al. Tumor necrosis factor-alpha-induced release of plasminogen activator inhibitor-1 from human umbilical vein endothelial cells: involvement of intracellular ceramide signaling event. 1998 Biochim. Biophys. Acta pmid:9824663
Costanzi E et al. Hypermethylation contributes to down-regulation of lysosomal β-hexosaminidase α subunit in prostate cancer cells. 2014 Biochimie pmid:24389457