N-acetylsphingosine

N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.

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Introduction

To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with N-acetylsphingosine?

N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine

MeSH term MeSH ID Detail
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Helicobacter Infections D016481 21 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Retinoblastoma D012175 12 associated lipids
Parkinson Disease D010300 53 associated lipids
Neuronal Ceroid-Lipofuscinoses D009472 5 associated lipids
Nerve Degeneration D009410 53 associated lipids
Melanoma D008545 69 associated lipids
Medulloblastoma D008527 22 associated lipids
Lung Neoplasms D008175 171 associated lipids
Leukemia D007938 74 associated lipids
Insulin Resistance D007333 99 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Glioma D005910 112 associated lipids
Fever D005334 35 associated lipids
Eye Abnormalities D005124 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with N-acetylsphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with N-acetylsphingosine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with N-acetylsphingosine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with N-acetylsphingosine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with N-acetylsphingosine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with N-acetylsphingosine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with N-acetylsphingosine

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Authors Title Published Journal PubMed Link
Kinscherf R et al. Apoptosis caused by oxidized LDL is manganese superoxide dismutase and p53 dependent. 1998 FASEB J. pmid:9535218
Harada-Shiba M et al. Oxidized low density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms. 1998 J. Biol. Chem. pmid:9545302
Foghi A et al. Fas-induced apoptosis in rat thecal/interstitial cells signals through sphingomyelin-ceramide pathway. 1998 Endocrinology pmid:9528992
Whitman SP et al. Protein kinase CbetaII activation by 1-beta-D-arabinofuranosylcytosine is antagonistic to stimulation of apoptosis and Bcl-2alpha down-regulation. 1997 J. Biol. Chem. pmid:9295281
Gill ZP et al. Insulin-like growth factor-binding protein (IGFBP-3) predisposes breast cancer cells to programmed cell death in a non-IGF-dependent manner. 1997 J. Biol. Chem. pmid:9325280
Kuo ML et al. Transforming growth factor beta1 attenuates ceramide-induced CPP32/Yama activation and apoptosis in human leukaemic HL-60 cells. 1997 Biochem. J. pmid:9581540
Bielawska AE et al. Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. 1997 Am. J. Pathol. pmid:9358751
Lozanski G et al. The sphingomyelin-ceramide pathway participates in cytokine regulation of C-reactive protein and serum amyloid A, but not alpha-fibrinogen. 1997 Biochem. J. pmid:9359864
Gudz TI et al. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. 1997 J. Biol. Chem. pmid:9305864
Mattson MP et al. Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. 1997 J. Neurosci. Res. pmid:9335256