| MeSH term | MeSH ID | Detail |
|---|---|---|
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Retinoblastoma | D012175 | 12 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Neuronal Ceroid-Lipofuscinoses | D009472 | 5 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Medulloblastoma | D008527 | 22 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Eye Abnormalities | D005124 | 7 associated lipids |
N-acetylsphingosine
N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
Cross Reference
Introduction
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with N-acetylsphingosine?
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
PubChem Associated disorders and diseases
What pathways are associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with N-acetylsphingosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with N-acetylsphingosine?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with N-acetylsphingosine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Miñano A et al. | C2-ceramide mediates cerebellar granule cells apoptosis by activation of caspases-2, -9, and -3. | 2008 | J. Neurosci. Res. | pmid:18311838 |
| Zhokhov SS et al. | Bax siRNA promotes survival of cultured and allografted granule cell precursors through blockade of caspase-3 cleavage. | 2008 | Cell Death Differ. | pmid:18323863 |
| Arboleda G et al. | Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells. | 2007 | Neurosci. Lett. | pmid:17573191 |
| Adachi T et al. | Membrane microdomain formation is crucial in epiboly during gastrulation of medaka. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17511962 |
| Kim S et al. | Design, synthesis, and preliminary biological evaluation of a novel triazole analogue of ceramide. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17561396 |
| Arboleda G et al. | Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells. | 2007 | Eur. J. Neurosci. | pmid:17561816 |
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| Abe A et al. | The acylation of lipophilic alcohols by lysosomal phospholipase A2. | 2007 | J. Lipid Res. | pmid:17626977 |
| JeBailey L et al. | Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells. | 2007 | Diabetes | pmid:17259384 |
| Yang LX et al. | [Association between murine double minute 2 expression and AngII and ceramide induced endothelial cells apoptosis]. | 2007 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:18206046 |
| Van Overloop H et al. | On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. | 2007 | Biol. Chem. | pmid:17338639 |
| Stoeck A et al. | L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. | 2007 | Gynecol. Oncol. | pmid:17030349 |
| Ulrich S et al. | De novo ceramide biosynthesis is associated with resveratrol-induced inhibition of ornithine decarboxylase activity. | 2007 | Biochem. Pharmacol. | pmid:17521618 |
| Samadi A | Ceramide-induced cell death in lens epithelial cells. | 2007 | Mol. Vis. | pmid:17893663 |
| Wang J et al. | Mechanisms involved in ceramide-induced cell cycle arrest in human hepatocarcinoma cells. | 2007 | World J. Gastroenterol. | pmid:17373752 |
| Zhang TH et al. | Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinases. | 2007 | Acta Pharmacol. Sin. | pmid:17303009 |
| Gibanova NV et al. | Protective effect of the hexapeptide TGENHR on the TNF-induced death of HL-60 cells. | 2006 Sep-Oct | Dokl. Biochem. Biophys. | pmid:17286111 |
| Schumacher AM et al. | Death-associated protein kinase phosphorylates mammalian ribosomal protein S6 and reduces protein synthesis. | 2006 | Biochemistry | pmid:17087515 |
| MacRae VE et al. | Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent. | 2006 | J. Endocrinol. | pmid:17088406 |
| Chen S et al. | Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes. | 2006 | J. Neurochem. | pmid:16524368 |