| MeSH term | MeSH ID | Detail |
|---|---|---|
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Retinoblastoma | D012175 | 12 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Neuronal Ceroid-Lipofuscinoses | D009472 | 5 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Medulloblastoma | D008527 | 22 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Eye Abnormalities | D005124 | 7 associated lipids |
N-acetylsphingosine
N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
Cross Reference
Introduction
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with N-acetylsphingosine?
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
PubChem Associated disorders and diseases
What pathways are associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with N-acetylsphingosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with N-acetylsphingosine?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with N-acetylsphingosine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Falluel-Morel A et al. | Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and PACAP through a MAP-kinase-dependent mechanism in cerebellar granule cells. | 2004 | J. Neurochem. | pmid:15569266 |
| Murase T et al. | Ceramide enhances acrosomal exocytosis triggered by calcium and the calcium ionophore A23187 in boar spermatozoa. | 2004 | J. Reprod. Dev. | pmid:15647619 |
| Pilane CM and LaBelle EF | NO induced apoptosis of vascular smooth muscle cells accompanied by ceramide increase. | 2004 | J. Cell. Physiol. | pmid:15040013 |
| Shayman JA et al. | A turn in the road: How studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A2 with ceramide transacylase activity. | 2004 | Glycoconj. J. | pmid:14973367 |
| d'Anglemont de Tassigny A et al. | Volume-sensitive chloride channels (ICl,vol) mediate doxorubicin-induced apoptosis through apoptotic volume decrease in cardiomyocytes. | 2004 | Fundam Clin Pharmacol | pmid:15482374 |
| Blázquez C et al. | Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. | 2004 | Cancer Res. | pmid:15313899 |
| Yao N et al. | The mitochondrion--an organelle commonly involved in programmed cell death in Arabidopsis thaliana. | 2004 | Plant J. | pmid:15500474 |
| Hayashi M et al. | High sensitivity of fibroblast cell lines derived from LEC rats to heat treatment. | 2004 | J. Vet. Med. Sci. | pmid:15528845 |
| Kawano Y et al. | Synergistic effect of interleukin (IL)-1alpha and ceramide analogue on the production of IL-6, IL-8, and macrophage colony-stimulating factor by endometrial stromal cells. | 2004 | Fertil. Steril. | pmid:15474071 |
| Ito Y et al. | Reduction of airway anion secretion via CFTR in sphingomyelin pathway. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15474513 |
| Schultz A and Larsson C | Ceramide influences neurite outgrowth and neuroblastoma cell apoptosis regulated by novel protein kinase C isoforms. | 2004 | J. Neurochem. | pmid:15189345 |
| Dawson G et al. | Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death. | 2004 | J. Neurochem. | pmid:15189346 |
| Daido S et al. | Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. | 2004 | Cancer Res. | pmid:15205343 |
| Perks CM et al. | Prolactin acts as a potent survival factor for human breast cancer cell lines. | 2004 | Br. J. Cancer | pmid:15213724 |
| Park IN et al. | Ceramide negatively regulates glutathione S-transferase gene transactivation via repression of hepatic nuclear factor-1 that is degraded by the ubiquitin proteasome system. | 2004 | Mol. Pharmacol. | pmid:15155840 |
| Fernandez S et al. | Inhibition of IL-10 receptor function in alveolar macrophages by Toll-like receptor agonists. | 2004 | J. Immunol. | pmid:14764735 |
| Niiro H et al. | (3Z)-2-Acetylamino-3-octadecen-1-ol as a potent apoptotic agent against HL-60 cells. | 2004 | Bioorg. Med. Chem. | pmid:14697769 |
| Hida A et al. | Nitric oxide acts on the mitochondria and protects human endothelial cells from apoptosis. | 2004 | J. Lab. Clin. Med. | pmid:15454884 |
| Shack S et al. | Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. | 2003 | Mol. Cell. Biol. | pmid:12640124 |
| Perks CM et al. | Prolactin acts as a potent survival factor against C2-ceramide-induced apoptosis in human granulosa cells. | 2003 | Hum. Reprod. | pmid:14645190 |