N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
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Zhang TH et al. | Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinases. | 2007 | Acta Pharmacol. Sin. | pmid:17303009 |
Hanna AN et al. | Tumor necrosis factor-alpha, sphingomyelinase and ceramides activate tyrosine kinase, p21Ras and phosphatidylinositol 3-kinase: implications for glucose transport and insulin resistance. | 2001 | Adv. Exp. Med. Biol. | pmid:11900368 |
Chik CL et al. | Ceramide inhibits L-type calcium channel currents in rat pinealocytes. | 1999 | Adv. Exp. Med. Biol. | pmid:10810500 |
Chmura SJ et al. | Cross-talk between ceramide and PKC activity in the control of apoptosis in WEHI-231. | 1996 | Adv. Exp. Med. Biol. | pmid:8910670 |
Bielawska AE et al. | Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. | 1997 | Am. J. Pathol. | pmid:9358751 |
Kimura T et al. | Inhibition of TSH-induced hydrogen peroxide production by TNF-alpha through a sphingomyelinase signaling pathway. | 1997 | Am. J. Physiol. | pmid:9316456 |
Yorek MA et al. | Effect of TNF-alpha on SMIT mRNA levels and myo-inositol accumulation in cultured endothelial cells. | 1998 | Am. J. Physiol. | pmid:9458713 |
Su X et al. | Differential activation of phosphoinositide 3-kinase by endothelin and ceramide in colonic smooth muscle cells. | 1999 | Am. J. Physiol. | pmid:10198327 |
Wang P and Bitar KN | Rho A regulates sustained smooth muscle contraction through cytoskeletal reorganization of HSP27. | 1998 | Am. J. Physiol. | pmid:9843784 |