N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Abrahan CE et al. | Synthesis of sphingosine is essential for oxidative stress-induced apoptosis of photoreceptors. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:19797232 |
Chen JY et al. | Additive effects of C(2)-ceramide on paclitaxel-induced premature senescence of human lung cancer cells. | 2010 | Life Sci. | pmid:20624405 |
Fontés G et al. | Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells. | 2009 | Diabetes | pmid:19502418 |
Kang JH et al. | Ceramides: branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency. | 2009 | Bioorg. Med. Chem. | pmid:19171486 |
Graf C et al. | A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. | 2009 | Anal. Biochem. | pmid:18831956 |
Furuchi T et al. | Apoptotic inducers activate the release of D-aspartate through a hypotonic stimulus-triggered mechanism in PC12 cells. | 2009 | Arch. Biochem. Biophys. | pmid:19720044 |
Wang J et al. | Potential mechanisms involved in ceramide-induced apoptosis in human colon cancer HT29 cells. | 2009 | Biomed. Environ. Sci. | pmid:19462692 |
Li R et al. | Alpha A-crystallin and alpha B-crystallin, newly identified interaction proteins of protease-activated receptor-2, rescue astrocytes from C2-ceramide- and staurosporine-induced cell death. | 2009 | J. Neurochem. | pmid:19558454 |
Lin YC et al. | Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19435666 |
Chien CC et al. | Activation of telomerase and cyclooxygenase-2 in PDGF and FGF inhibition of C2-ceramide-induced apoptosis. | 2009 | J. Cell. Physiol. | pmid:18932216 |