N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Migita K et al. | Regulation of rheumatoid synovial cell growth by ceramide. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10694479 |
Galve-Roperh I et al. | Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. | 2000 | Nat. Med. | pmid:10700234 |
Dawson G | Mechanisms of apoptosis in embryonic cortical neurons (E6 and E7) in culture involve lipid signalling, protein phosphorylation and caspase activation. | 2000 Apr-Jun | Int. J. Dev. Neurosci. | pmid:10715579 |
Lobner D | Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis? | 2000 | J. Neurosci. Methods | pmid:10720679 |
Kondo T et al. | Suppression of heat shock protein-70 by ceramide in heat shock-induced HL-60 cell apoptosis. | 2000 | J. Biol. Chem. | pmid:10722733 |
Kim HS et al. | Induction of apoptosis by all-trans-retinoic acid and C2-ceramide treatment in rat stromal-vascular cultures. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10733907 |
Cho S and Dawson G | Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells. | 2000 | J. Neurochem. | pmid:10737604 |
Chan C and Goldkorn T | Ceramide path in human lung cell death. | 2000 | Am. J. Respir. Cell Mol. Biol. | pmid:10745027 |
Brás A et al. | Ceramide-induced cell death is independent of the Fas/Fas ligand pathway and is prevented by Nur77 overexpression in A20 B cells. | 2000 | Cell Death Differ. | pmid:10745271 |
Ahmed N and Berridge MV | Ceramides that mediate apoptosis reduce glucose uptake and transporter affinity for glucose in human leukaemic cell lines but not in neutrophils. | 2000 | Pharmacol. Toxicol. | pmid:10752668 |