N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Jäättelä M et al. | Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. | 1995 | Oncogene | pmid:7540278 |
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Kiss Z and Deli E | Preferential inhibition of phorbol ester-induced hydrolysis of phosphatidylethanolamine by N-acetylsphingosine in NIH 3T3 fibroblasts. | 1995 | FEBS Lett. | pmid:7781767 |
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Welsh N | Interleukin-1 beta-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F. | 1996 | J. Biol. Chem. | pmid:8626526 |
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Kaipia A et al. | Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles. | 1996 | Endocrinology | pmid:8895358 |
Chmura SJ et al. | Cross-talk between ceramide and PKC activity in the control of apoptosis in WEHI-231. | 1996 | Adv. Exp. Med. Biol. | pmid:8910670 |
Metz RJ et al. | Vitamin D3 and ceramide reduce the invasion of tumor cells through extracellular matrix components by elevating protein phosphatase-2A. | 1996 | Invasion Metastasis | pmid:9371227 |
Cuvillier O et al. | Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. | 1996 | Nature | pmid:8657285 |
Degnan BM et al. | Sphingomyelinase inhibits in vitro Leydig cell function. | 1996 May-Jun | Ann. Clin. Lab. Sci. | pmid:8726216 |
Pörn-Ares MI et al. | Induction of apoptosis and potentiation of TNF- and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609. | 1997 | Exp. Cell Res. | pmid:9281351 |
Whitman SP et al. | Protein kinase CbetaII activation by 1-beta-D-arabinofuranosylcytosine is antagonistic to stimulation of apoptosis and Bcl-2alpha down-regulation. | 1997 | J. Biol. Chem. | pmid:9295281 |
Kimura T et al. | Inhibition of TSH-induced hydrogen peroxide production by TNF-alpha through a sphingomyelinase signaling pathway. | 1997 | Am. J. Physiol. | pmid:9316456 |
Larocca JN et al. | Induction of oligodendrocyte apoptosis by C2-ceramide. | 1997 | Neurochem. Res. | pmid:9130266 |
Gill ZP et al. | Insulin-like growth factor-binding protein (IGFBP-3) predisposes breast cancer cells to programmed cell death in a non-IGF-dependent manner. | 1997 | J. Biol. Chem. | pmid:9325280 |
Nakabo Y and Pabst MJ | C2-ceramide and C6-ceramide inhibited priming for enhanced release of superoxide in monocytes, but had no effect on the killing of leukaemic cells by monocytes. | 1997 | Immunology | pmid:9176098 |
Wieder T et al. | Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues. | 1997 | FEBS Lett. | pmid:9271217 |
Xie H and Johnson GV | Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I. | 1997 | J. Neurochem. | pmid:9282924 |
Manev H and Cagnoli CM | Ceramide-mediated and isoquinolinesulfonamide-sensitive pathways of neuronal death: anything in common? | 1997 | Neurochem. Int. | pmid:9220452 |
Keane RW et al. | Activation of CPP32 during apoptosis of neurons and astrocytes. | 1997 | J. Neurosci. Res. | pmid:9130145 |
Separovic D et al. | Ceramide generation in response to photodynamic treatment of L5178Y mouse lymphoma cells. | 1997 | Cancer Res. | pmid:9135014 |
GarcÃa-Ruiz C et al. | Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. | 1997 | J. Biol. Chem. | pmid:9111045 |
Baker A et al. | Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo. | 1997 | Cancer Res. | pmid:9371519 |
Kuo ML et al. | Transforming growth factor beta1 attenuates ceramide-induced CPP32/Yama activation and apoptosis in human leukaemic HL-60 cells. | 1997 | Biochem. J. | pmid:9581540 |
Bielawska AE et al. | Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. | 1997 | Am. J. Pathol. | pmid:9358751 |
Lozanski G et al. | The sphingomyelin-ceramide pathway participates in cytokine regulation of C-reactive protein and serum amyloid A, but not alpha-fibrinogen. | 1997 | Biochem. J. | pmid:9359864 |
Gudz TI et al. | Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. | 1997 | J. Biol. Chem. | pmid:9305864 |
Mattson MP et al. | Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. | 1997 | J. Neurosci. Res. | pmid:9335256 |
Bártová E et al. | Apoptotic damage of DNA in human leukaemic HL-60 cells treated with C2-ceramide was detected after G1 blockade of the cell cycle. | 1997 | Physiol Res | pmid:9727507 |
Shinkai M et al. | Inhibitory action of sphingosine or ceramide on amylase secretion from isolated rat pancreatic acini. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9196062 |
Shirahama T et al. | Sphingosine induces apoptosis in androgen-independent human prostatic carcinoma DU-145 cells by suppression of bcl-X(L) gene expression. | 1997 | FEBS Lett. | pmid:9141489 |
Kozawa O et al. | Tumor necrosis factor-alpha autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C. | 1997 | J. Biol. Chem. | pmid:9312119 |