N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kuo ML et al. | Transforming growth factor beta1 attenuates ceramide-induced CPP32/Yama activation and apoptosis in human leukaemic HL-60 cells. | 1997 | Biochem. J. | pmid:9581540 |
Kirtikara K et al. | An accessory role for ceramide in interleukin-1beta induced prostaglandin synthesis. | 1998 | Mol. Cell. Biochem. | pmid:9562240 |
Hashizume T et al. | Different effects of cell-permeable ceramide analogs on platelet activation. | 1998 | Biochem. Mol. Biol. Int. | pmid:9556209 |
Kishida E et al. | Distinctive inhibitory activity of docosahexaenoic acid against sphingosine-induced apoptosis. | 1998 | Biochim. Biophys. Acta | pmid:9555103 |
Harada-Shiba M et al. | Oxidized low density lipoprotein induces apoptosis in cultured human umbilical vein endothelial cells by common and unique mechanisms. | 1998 | J. Biol. Chem. | pmid:9545302 |
Iwasaki-Bessho Y et al. | Decreased phospholipase D (PLD) activity in ceramide-induced apoptosis of human keratinocyte cell line HaCaT. | 1998 | J. Invest. Dermatol. | pmid:9540978 |
Kinscherf R et al. | Apoptosis caused by oxidized LDL is manganese superoxide dismutase and p53 dependent. | 1998 | FASEB J. | pmid:9535218 |
Veldman RJ et al. | Metabolism and apoptotic properties of elevated ceramide in HT29rev cells. | 1998 | Biochem. J. | pmid:9531498 |
Flores I et al. | Dual role of ceramide in the control of apoptosis following IL-2 withdrawal. | 1998 | J. Immunol. | pmid:9531315 |
Foghi A et al. | Fas-induced apoptosis in rat thecal/interstitial cells signals through sphingomyelin-ceramide pathway. | 1998 | Endocrinology | pmid:9528992 |