N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
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Shklyaev SS et al. | Involvement of wild-type p53 in radiation-induced c-Jun N-terminal kinase activation in human thyroid cells. | 2001 Jul-Aug | Anticancer Res. | pmid:11724323 |
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Kralik SF et al. | Ceramide and glucosamine antagonism of alternate signaling pathways regulating insulin- and osmotic shock-induced glucose transporter 4 translocation. | 2002 | Endocrinology | pmid:11751589 |
Abousalham A et al. | Cell-permeable ceramides preferentially inhibit coated vesicle formation and exocytosis in Chinese hamster ovary compared with Madin-Darby canine kidney cells by preventing the membrane association of ADP-ribosylation factor. | 2002 | Biochem. J. | pmid:11802796 |
Deng J et al. | Ceramide does not act as a general second messenger for ultraviolet-induced apoptosis. | 2002 | Oncogene | pmid:11791175 |
Mansfield PJ et al. | Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D. | 2002 | Blood | pmid:11830497 |
Phillips DC et al. | Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status. | 2002 | Arch. Biochem. Biophys. | pmid:12392710 |
Conway EM et al. | Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways. | 2002 | Gastroenterology | pmid:12145814 |
Toman RE et al. | Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis. | 2002 | J. Neurosci. Res. | pmid:12111862 |
Todaro M et al. | High levels of exogenous C2-ceramide promote morphological and biochemical evidences of necrotic features in thyroid follicular cells. | 2002 | J. Cell. Biochem. | pmid:12112027 |
Hearps AC et al. | Mitochondrial cytochrome c release precedes transmembrane depolarisation and caspase-3 activation during ceramide-induced apoptosis of Jurkat T cells. | 2002 | Apoptosis | pmid:12207171 |
Gómez Del Pulgar T et al. | Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway. | 2002 | J. Biol. Chem. | pmid:12133838 |
Poppe M et al. | Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression. | 2002 | J. Neurochem. | pmid:12153473 |
Soltys CL et al. | Phosphorylation of cardiac protein kinase B is regulated by palmitate. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12181135 |
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Gurunathan S et al. | t-SNARE phosphorylation regulates endocytosis in yeast. | 2002 | Mol. Biol. Cell | pmid:12006655 |
Sprott KM et al. | Decreased activity and enhanced nuclear export of CCAAT-enhancer-binding protein beta during inhibition of adipogenesis by ceramide. | 2002 | Biochem. J. | pmid:12071851 |
Han WS et al. | Effects of C2-ceramide on the Malme-3M melanoma cell line. | 2002 | J. Dermatol. Sci. | pmid:12354415 |
Zhang YH et al. | Ceramide, a putative second messenger for nerve growth factor, modulates the TTX-resistant Na(+) current and delayed rectifier K(+) current in rat sensory neurons. | 2002 | J. Physiol. (Lond.) | pmid:12381813 |
Marques M et al. | Identification of platelet-activating factor acetylhydrolase II in human skin. | 2002 | J. Invest. Dermatol. | pmid:12406338 |
Xiao AY et al. | Slight impairment of Na+,K+-ATPase synergistically aggravates ceramide- and beta-amyloid-induced apoptosis in cortical neurons. | 2002 | Brain Res. | pmid:12419544 |
Shin CY et al. | C(2)-ceramide-induced circular smooth muscle cell contraction involves PKC-epsilon and p44/p42 MAPK activation in cat oesophagus. Mitogen-activated protein kinase. | 2002 | Cell. Signal. | pmid:12220618 |
De Stefanis D et al. | Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells. | 2002 | Biol. Chem. | pmid:12222689 |
Ramos B et al. | Inhibition of CTP:phosphocholine cytidylyltransferase by C(2)-ceramide and its relationship to apoptosis. | 2002 | Mol. Pharmacol. | pmid:12391269 |
Colligan PB et al. | Ceramide attenuates high glucose-induced cardiac contractile abnormalities in cultured adult rat ventricular myocytes. | 2002 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:12643441 |
Siskind LJ et al. | Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. | 2002 | J. Biol. Chem. | pmid:12006562 |
Kim DS et al. | Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes. | 2002 | Cell. Signal. | pmid:12034359 |
Preaux AM et al. | Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2. | 2002 | Hepatology | pmid:12198653 |
Mallick S et al. | Human placental lipid induces mitogenesis and melanogenesis in B16F10 melanoma cells. | 2002 | J. Biosci. | pmid:12089473 |
Kozawa O et al. | Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide. | 2002 | Cell. Signal. | pmid:12359305 |