N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Reunanen N et al. | Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathways. | 1998 | J. Biol. Chem. | pmid:9478967 |
Kim BC and Kim JH | Exogenous C2-ceramide activates c-fos serum response element via Rac-dependent signalling pathway. | 1998 | Biochem. J. | pmid:9480923 |
Rossner S et al. | p75 and TrkA receptor signaling independently regulate amyloid precursor protein mRNA expression, isoform composition, and protein secretion in PC12 cells. | 1998 | J. Neurochem. | pmid:9681467 |
Mizushima N et al. | Ceramide, a mediator of interleukin 1, tumour necrosis factor alpha, as well as Fas receptor signalling, induces apoptosis of rheumatoid arthritis synovial cells. | 1998 | Ann. Rheum. Dis. | pmid:9797556 |
Ji L et al. | Effects of endoglycoceramidase or D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol on glucose uptake, glycolysis, and mitochondrial respiration in HL60 cells. | 1998 | Arch. Biochem. Biophys. | pmid:9799567 |
Ichinose Y et al. | Apoptosis induction in synovial fibroblasts by ceramide: in vitro and in vivo effects. | 1998 | J. Lab. Clin. Med. | pmid:9605105 |
Canova C et al. | Epigenetic control of programmed cell death: inhibition by 5-azacytidine of 1,25-dihydroxyvitamin D3-induced programmed cell death in C6.9 glioma cells. | 1998 | Mech. Ageing Dev. | pmid:9593321 |
Boland MP and O'Neill LA | Ceramide activates NFkappaB by inducing the processing of p105. | 1998 | J. Biol. Chem. | pmid:9624136 |
Wang P and Bitar KN | Rho A regulates sustained smooth muscle contraction through cytoskeletal reorganization of HSP27. | 1998 | Am. J. Physiol. | pmid:9843784 |
Soeda S et al. | Tumor necrosis factor-alpha-induced release of plasminogen activator inhibitor-1 from human umbilical vein endothelial cells: involvement of intracellular ceramide signaling event. | 1998 | Biochim. Biophys. Acta | pmid:9824663 |