N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kim S et al. | Design, synthesis, and preliminary biological evaluation of a novel triazole analogue of ceramide. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17561396 |
Shikata K et al. | Synthesis of non-natural C2-homo-ceramide and its apoptotic activity against HL-60 cells. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12639542 |
De Jonghe S et al. | Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10560744 |
Siskind LJ et al. | Enlargement and contracture of C2-ceramide channels. | 2003 | Biophys. J. | pmid:12944273 |
Hisano N et al. | Induction and suppression of endothelial cell apoptosis by sphingolipids: a possible in vitro model for cell-cell interactions between platelets and endothelial cells. | 1999 | Blood | pmid:10361127 |
Yabu T et al. | Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate. | 2005 | Blood | pmid:15741222 |
Chen CL et al. | Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. | 2008 | Blood | pmid:18270325 |
Suchard SJ et al. | Ceramide inhibits IgG-dependent phagocytosis in human polymorphonuclear leukocytes. | 1997 | Blood | pmid:9058737 |
Mansfield PJ et al. | Ceramide inhibition of phospholipase D and its relationship to RhoA and ARF1 translocation in GTP gamma S-stimulated polymorphonuclear leukocytes. | 2004 | Blood | pmid:14615385 |
Scheid MP et al. | Ceramide and cyclic adenosine monophosphate (cAMP) induce cAMP response element binding protein phosphorylation via distinct signaling pathways while having opposite effects on myeloid cell survival. | 1999 | Blood | pmid:9864164 |