N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Bourbon NA et al. | Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest. | 2002 | J. Biol. Chem. | pmid:11723139 |
Lee TC et al. | Biosynthesis of N-acetylsphingosine by platelet-activating factor: sphingosine CoA-independent transacetylase in HL-60 cels. | 1996 | J. Biol. Chem. | pmid:8550561 |
Xin M and Deng X | Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation. | 2006 | J. Biol. Chem. | pmid:16679323 |
Cuvillier O et al. | Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes. | 1998 | J. Biol. Chem. | pmid:9446602 |
Micoli KJ et al. | Requirement of calmodulin binding by HIV-1 gp160 for enhanced FAS-mediated apoptosis. | 2000 | J. Biol. Chem. | pmid:10625668 |
Sawai H et al. | Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells. | 1995 | J. Biol. Chem. | pmid:7592995 |
Gill ZP et al. | Insulin-like growth factor-binding protein (IGFBP-3) predisposes breast cancer cells to programmed cell death in a non-IGF-dependent manner. | 1997 | J. Biol. Chem. | pmid:9325280 |
Gudz TI et al. | Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. | 1997 | J. Biol. Chem. | pmid:9305864 |
Mutoh T et al. | Glucosylceramide synthase inhibitor inhibits the action of nerve growth factor in PC12 cells. | 1998 | J. Biol. Chem. | pmid:9748278 |
Taniguchi M et al. | Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway. | 2012 | J. Biol. Chem. | pmid:23035115 |
Medvedev AE et al. | Limited role of ceramide in lipopolysaccharide-mediated mitogen-activated protein kinase activation, transcription factor induction, and cytokine release. | 1999 | J. Biol. Chem. | pmid:10092612 |
Mahajan S et al. | Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamide]. | 1999 | J. Biol. Chem. | pmid:10092645 |
Gubern A et al. | Lipid droplet biogenesis induced by stress involves triacylglycerol synthesis that depends on group VIA phospholipase A2. | 2009 | J. Biol. Chem. | pmid:19117952 |
Kozawa O et al. | Tumor necrosis factor-alpha autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C. | 1997 | J. Biol. Chem. | pmid:9312119 |
Mallick S et al. | Human placental lipid induces mitogenesis and melanogenesis in B16F10 melanoma cells. | 2002 | J. Biosci. | pmid:12089473 |
Jaiswal AS and Narayan S | Reduced levels of the adenomatous polyposis coli (APC) protein are associated with ceramide-induced apoptosis of colon cancer cells. | 2004 | J. Cancer Res. Clin. Oncol. | pmid:15340841 |
Olivera A et al. | Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. | 1999 | J. Cell Biol. | pmid:10545499 |
Rapizzi E et al. | Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria. | 2002 | J. Cell Biol. | pmid:12438411 |
Zhou H et al. | Akt regulates cell survival and apoptosis at a postmitochondrial level. | 2000 | J. Cell Biol. | pmid:11062251 |
Todaro M et al. | High levels of exogenous C2-ceramide promote morphological and biochemical evidences of necrotic features in thyroid follicular cells. | 2002 | J. Cell. Biochem. | pmid:12112027 |
Hughes PJ et al. | Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. | 2006 | J. Cell. Biochem. | pmid:16178010 |
Woessmann W et al. | An essential role for mitogen-activated protein kinases, ERKs, in preventing heat-induced cell death. | 1999 | J. Cell. Biochem. | pmid:10440934 |
Pilane CM and LaBelle EF | NO induced apoptosis of vascular smooth muscle cells accompanied by ceramide increase. | 2004 | J. Cell. Physiol. | pmid:15040013 |
Meadows KA et al. | Tumor necrosis factor-alpha-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts. | 2000 | J. Cell. Physiol. | pmid:10797307 |
Chien CC et al. | Activation of telomerase and cyclooxygenase-2 in PDGF and FGF inhibition of C2-ceramide-induced apoptosis. | 2009 | J. Cell. Physiol. | pmid:18932216 |
Kim DK et al. | Adaptive concentrations of hydrogen peroxide suppress cell death by blocking the activation of SAPK/JNK pathway. | 2001 | J. Cell. Sci. | pmid:11739664 |
Wang XQ et al. | Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress. | 2003 | J. Cell. Sci. | pmid:12679386 |
Fukunaga T et al. | Implication of sphingolipid metabolism in the stability of the Golgi apparatus. | 2000 | J. Cell. Sci. | pmid:10954427 |
Furuya K et al. | Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia. | 2001 | J. Cereb. Blood Flow Metab. | pmid:11295877 |
Chen Y et al. | The protective effect of ceramide in immature rat brain hypoxia-ischemia involves up-regulation of bcl-2 and reduction of TUNEL-positive cells. | 2001 | J. Cereb. Blood Flow Metab. | pmid:11149666 |
Muriel MP et al. | Mitochondrial free calcium levels (Rhod-2 fluorescence) and ultrastructural alterations in neuronally differentiated PC12 cells during ceramide-dependent cell death. | 2000 | J. Comp. Neurol. | pmid:10982470 |
Han WS et al. | Effects of C2-ceramide on the Malme-3M melanoma cell line. | 2002 | J. Dermatol. Sci. | pmid:12354415 |
MacRae VE et al. | Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent. | 2006 | J. Endocrinol. | pmid:17088406 |
Koide N et al. | C2-ceramide inhibits LPS-induced nitric oxide production in RAW 264.7 macrophage cells through down-regulating the activation of Akt. | 2003 | J. Endotoxin Res. | pmid:12803880 |
Frago LM et al. | Short-chain ceramide regulates hepatic methionine adenosyltransferase expression. | 2001 | J. Hepatol. | pmid:11281546 |
Hsu YW et al. | Ceramide inhibits lipopolysaccharide-mediated nitric oxide synthase and cyclooxygenase-2 induction in macrophages: effects on protein kinases and transcription factors. | 2001 | J. Immunol. | pmid:11313375 |
Menné C et al. | Ceramide-induced TCR up-regulation. | 2000 | J. Immunol. | pmid:10975817 |
Yeh MW et al. | Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l -cysteine. | 2000 | J. Immunol. | pmid:10754324 |
Flores I et al. | Dual role of ceramide in the control of apoptosis following IL-2 withdrawal. | 1998 | J. Immunol. | pmid:9531315 |
Lakics V and Vogel SN | Lipopolysaccharide and ceramide use divergent signaling pathways to induce cell death in murine macrophages. | 1998 | J. Immunol. | pmid:9725248 |
Lian JP et al. | Products of sphingolipid catabolism block activation of the p21-activated protein kinases in neutrophils. | 1998 | J. Immunol. | pmid:9780215 |
Bulanova E et al. | The IL-15R alpha chain signals through association with Syk in human B cells. | 2001 | J. Immunol. | pmid:11714793 |
Ragg SJ et al. | The mitogen-activated protein kinase pathway inhibits ceramide-induced terminal differentiation of a human monoblastic leukemia cell line, U937. | 1998 | J. Immunol. | pmid:9686602 |
Fernandez S et al. | Inhibition of IL-10 receptor function in alveolar macrophages by Toll-like receptor agonists. | 2004 | J. Immunol. | pmid:14764735 |
Marques M et al. | Identification of platelet-activating factor acetylhydrolase II in human skin. | 2002 | J. Invest. Dermatol. | pmid:12406338 |
Iwasaki-Bessho Y et al. | Decreased phospholipase D (PLD) activity in ceramide-induced apoptosis of human keratinocyte cell line HaCaT. | 1998 | J. Invest. Dermatol. | pmid:9540978 |
Mansfield PJ et al. | Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b(558) by gelatinase-granule release. | 2002 | J. Lab. Clin. Med. | pmid:12080323 |
Ichinose Y et al. | Apoptosis induction in synovial fibroblasts by ceramide: in vitro and in vivo effects. | 1998 | J. Lab. Clin. Med. | pmid:9605105 |
Hida A et al. | Nitric oxide acts on the mitochondria and protects human endothelial cells from apoptosis. | 2004 | J. Lab. Clin. Med. | pmid:15454884 |
Knapp KM and English BK | Ceramide-mediated stimulation of inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation in murine macrophages requires tyrosine kinase activity. | 2000 | J. Leukoc. Biol. | pmid:10811015 |
Abe A et al. | The acylation of lipophilic alcohols by lysosomal phospholipase A2. | 2007 | J. Lipid Res. | pmid:17626977 |
Ogiso H et al. | Analysis of lipid-composition changes in plasma membrane microdomains. | 2015 | J. Lipid Res. | pmid:26116739 |
Giltiay NV et al. | Ceramide- and ERK-dependent pathway for the activation of CCAAT/enhancer binding protein by interleukin-1beta in hepatocytes. | 2005 | J. Lipid Res. | pmid:16106045 |
Ghering AB and Davidson WS | Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I. | 2006 | J. Lipid Res. | pmid:16990644 |
Klapisz E et al. | Sphingolipids and cholesterol modulate membrane susceptibility to cytosolic phospholipase A(2). | 2000 | J. Lipid Res. | pmid:11013311 |
Abe A et al. | Preferential hydrolysis of truncated oxidized glycerophospholipids by lysosomal phospholipase A2. | 2017 | J. Lipid Res. | pmid:27993948 |
Macchia M et al. | Design, synthesis, and characterization of the antitumor activity of novel ceramide analogues. | 2001 | J. Med. Chem. | pmid:11689086 |
Sakai T et al. | Effects of alpha- and beta-galactosylated C2-ceramides on the immune system. | 1998 | J. Med. Chem. | pmid:9484513 |
Arboleda G et al. | Metabolic activity: a novel indicator of neuronal survival in the murine dopaminergic cell line CAD. | 2005 | J. Mol. Neurosci. | pmid:16055947 |
Sánchez-Mora RM et al. | PINK1 overexpression protects against C2-ceramide-induced CAD cell death through the PI3K/AKT pathway. | 2012 | J. Mol. Neurosci. | pmid:22212487 |
Falluel-Morel A et al. | Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and PACAP through a MAP-kinase-dependent mechanism in cerebellar granule cells. | 2004 | J. Neurochem. | pmid:15569266 |
Blázquez C et al. | The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme. | 1999 | J. Neurochem. | pmid:10098887 |
Aubert N et al. | PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway: involvement of c-Fos in PACAP-induced Bcl-2 expression. | 2006 | J. Neurochem. | pmid:17026529 |
Poppe M et al. | Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression. | 2002 | J. Neurochem. | pmid:12153473 |
Chen S et al. | Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes. | 2006 | J. Neurochem. | pmid:16524368 |
Sabirzhanov B et al. | Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis. | 2012 | J. Neurochem. | pmid:22909049 |
Darios F et al. | Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death. | 2003 | J. Neurochem. | pmid:12562509 |
Schultz A and Larsson C | Ceramide influences neurite outgrowth and neuroblastoma cell apoptosis regulated by novel protein kinase C isoforms. | 2004 | J. Neurochem. | pmid:15189345 |
Wiesner DA and Dawson G | Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway. | 1996 | J. Neurochem. | pmid:8627293 |
Xie H and Johnson GV | Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I. | 1997 | J. Neurochem. | pmid:9282924 |
Rossner S et al. | p75 and TrkA receptor signaling independently regulate amyloid precursor protein mRNA expression, isoform composition, and protein secretion in PC12 cells. | 1998 | J. Neurochem. | pmid:9681467 |
Dawson G et al. | Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death. | 2004 | J. Neurochem. | pmid:15189346 |
Edsall LC et al. | Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. | 2001 | J. Neurochem. | pmid:11238741 |
Pascual M et al. | Ceramide pathways modulate ethanol-induced cell death in astrocytes. | 2003 | J. Neurochem. | pmid:14713309 |
Hartfield PJ et al. | Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells. | 1998 | J. Neurochem. | pmid:9648862 |
Patel M | Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic. | 1998 | J. Neurochem. | pmid:9721731 |
MacPhee I and Barker PA | Extended ceramide exposure activates the trkA receptor by increasing receptor homodimer formation. | 1999 | J. Neurochem. | pmid:10098845 |
Li R and Reiser G | Phosphorylation of Ser45 and Ser59 of αB-crystallin and p38/extracellular regulated kinase activity determine αB-crystallin-mediated protection of rat brain astrocytes from C2-ceramide- and staurosporine-induced cell death. | 2011 | J. Neurochem. | pmid:21615407 |
Cho S and Dawson G | Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells. | 2000 | J. Neurochem. | pmid:10737604 |
Li R et al. | Alpha A-crystallin and alpha B-crystallin, newly identified interaction proteins of protease-activated receptor-2, rescue astrocytes from C2-ceramide- and staurosporine-induced cell death. | 2009 | J. Neurochem. | pmid:19558454 |
Pahan K et al. | Induction of the manganese superoxide dismutase gene by sphingomyelinase and ceramide. | 1999 | J. Neurochem. | pmid:10428046 |
Yoshimura S et al. | Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death. | 1999 | J. Neurochem. | pmid:10428064 |
Sée V et al. | C2-ceramide and reactive oxygen species inhibit pituitary adenylate cyclase activating polypeptide (PACAP)-induced cyclic-AMP-dependent signalling pathway. | 2001 | J. Neurochem. | pmid:11158249 |
Luther JA et al. | Neurotrophins regulate cholinergic synaptic transmission in cultured rat sympathetic neurons through a p75-dependent mechanism. | 2013 | J. Neurophysiol. | pmid:23114219 |
Xiao Q et al. | Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia. | 2012 | J. Neurosci. | pmid:23015448 |
Lobner D | Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis? | 2000 | J. Neurosci. Methods | pmid:10720679 |
Miñano A et al. | C2-ceramide mediates cerebellar granule cells apoptosis by activation of caspases-2, -9, and -3. | 2008 | J. Neurosci. Res. | pmid:18311838 |
Goswami R et al. | Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines. | 2005 | J. Neurosci. Res. | pmid:15968641 |
Toman RE et al. | Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis. | 2002 | J. Neurosci. Res. | pmid:12111862 |
Kimura M et al. | Release of plasminogen activator inhibitor-1 from human astrocytes is regulated by intracellular ceramide. | 2000 | J. Neurosci. Res. | pmid:11107162 |
Keane RW et al. | Activation of CPP32 during apoptosis of neurons and astrocytes. | 1997 | J. Neurosci. Res. | pmid:9130145 |
Mattson MP et al. | Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. | 1997 | J. Neurosci. Res. | pmid:9335256 |
Hatano M et al. | Enhancement of C2-ceramide antitumor activity by small interfering RNA on X chromosome-linked inhibitor of apoptosis protein in resistant human glioma cells. | 2004 | J. Neurosurg. | pmid:15255262 |
Hunsperger EA and Wilcox CL | Caspase-3-dependent reactivation of latent herpes simplex virus type 1 in sensory neuronal cultures. | 2003 | J. Neurovirol. | pmid:12775421 |
Lu CY et al. | Docosahexaenoic acid down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the sphingomyelinase/ceramide pathway. | 2010 | J. Nutr. Biochem. | pmid:19427778 |
Zhang YH et al. | Ceramide, a putative second messenger for nerve growth factor, modulates the TTX-resistant Na(+) current and delayed rectifier K(+) current in rat sensory neurons. | 2002 | J. Physiol. (Lond.) | pmid:12381813 |
Wang Y et al. | Acid sphingomyelinase mediates 50-Hz magnetic field-induced EGF receptor clustering on lipid raft. | 2016 | J. Recept. Signal Transduct. Res. | pmid:26915736 |
Murase T et al. | Ceramide enhances acrosomal exocytosis triggered by calcium and the calcium ionophore A23187 in boar spermatozoa. | 2004 | J. Reprod. Dev. | pmid:15647619 |
Zhang J et al. | Impaired Fas-induced apoptosis of T lymphocytes in patients with abdominal aortic aneurysms. | 2007 | J. Vasc. Surg. | pmid:17350784 |
Hayashi M et al. | High sensitivity of fibroblast cell lines derived from LEC rats to heat treatment. | 2004 | J. Vet. Med. Sci. | pmid:15528845 |