N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Latorre E et al. | Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide. | 2003 | Eur. J. Biochem. | pmid:12492473 |
Arboleda G et al. | Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells. | 2007 | Eur. J. Neurosci. | pmid:17561816 |
Willaime S et al. | Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation. | 2001 | Eur. J. Neurosci. | pmid:11422444 |
Cho S et al. | Role of palmitoyl-protein thioesterase in cell death: implications for infantile neuronal ceroid lipofuscinosis. | 2001 | Eur. J. Paediatr. Neurol. | pmid:11589008 |
Zhang X et al. | Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis. | 2012 | Eur. J. Pharmacol. | pmid:22296759 |
Young KW et al. | Effect of dimethylsphingosine on muscarinic M(3) receptor signalling in SH-SY5Y cells. | 2000 | Eur. J. Pharmacol. | pmid:10940357 |
Johns DG et al. | The role of the endothelium in ceramide-induced vasodilation. | 1998 | Eur. J. Pharmacol. | pmid:9671089 |
Guidarelli A et al. | TNFalpha enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation. | 2001 | Exp. Cell Res. | pmid:11597127 |
Pörn-Ares MI et al. | Induction of apoptosis and potentiation of TNF- and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609. | 1997 | Exp. Cell Res. | pmid:9281351 |
Fujikawa K et al. | Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells. | 1999 | Exp. Cell Res. | pmid:10585289 |
Durrieu F et al. | Caspase activation is an early event in anthracycline-induced apoptosis and allows detection of apoptotic cells before they are ingested by phagocytes. | 1998 | Exp. Cell Res. | pmid:9596989 |
Mengubas K et al. | Killing of T lymphocytes by synthetic ceramide is by a nonapoptotic mechanism and is abrogated following mitogenic activation. | 1999 | Exp. Cell Res. | pmid:10328959 |
Yakushiji K et al. | Characterization of C2-ceramide-resistant HL-60 subline (HL-CR): involvement of PKC delta in C2-ceramide resistance. | 2003 | Exp. Cell Res. | pmid:12749866 |
Lee BR and Um HD | Hydrogen peroxide suppresses U937 cell death by two different mechanisms depending on its concentration. | 1999 | Exp. Cell Res. | pmid:10222135 |
Herrmann JL et al. | Regulation of lipid signaling pathways for cell survival and apoptosis by bcl-2 in prostate carcinoma cells. | 1997 | Exp. Cell Res. | pmid:9260915 |
Hampel B et al. | Differential regulation of apoptotic cell death in senescent human cells. | 2004 Nov-Dec | Exp. Gerontol. | pmid:15582287 |
Itakura A et al. | Ceramide and sphingosine rapidly induce apoptosis of murine mast cells supported by interleukin-3 and stem cell factor. | 2002 | Exp. Hematol. | pmid:11882365 |
Dallalio G et al. | Inhibition of human erythroid colony formation by ceramide. | 1999 | Exp. Hematol. | pmid:10390188 |
Park HW et al. | Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells. | 2004 | Exp. Mol. Med. | pmid:15557813 |
Park BJ et al. | Effect of ceramide on apoptosis and phospholipase D activity in FRTL-5 thyroid cells. | 1999 | Exp. Mol. Med. | pmid:10551263 |
Huang C et al. | Involvement of sphingomyelinase in insulin-induced phosphatidylinositol 3-kinase activation. | 2001 | FASEB J. | pmid:11292685 |
Kinscherf R et al. | Apoptosis caused by oxidized LDL is manganese superoxide dismutase and p53 dependent. | 1998 | FASEB J. | pmid:9535218 |
Jaffrézou JP et al. | Positive feedback control of neutral sphingomyelinase activity by ceramide. | 1998 | FASEB J. | pmid:9707172 |
Pozuelo-Rubio M | Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. | 2010 | FEBS J. | pmid:20618440 |
Calcerrada MC et al. | Involvement of phosphatidylinositol 3-kinase in nuclear translocation of protein kinase C zeta induced by C2-ceramide in rat hepatocytes. | 2002 | FEBS Lett. | pmid:11943182 |
Susen K et al. | Nerve growth factor stimulates MAPK via the low affinity receptor p75(LNTR). | 1999 | FEBS Lett. | pmid:10606727 |
Ruiz L et al. | Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism. | 1999 | FEBS Lett. | pmid:10570948 |
Raisova M et al. | Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release. | 2000 | FEBS Lett. | pmid:10802053 |
Mizushima N et al. | Ceramide induces apoptosis via CPP32 activation. | 1996 | FEBS Lett. | pmid:8898109 |
Wieder T et al. | Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues. | 1997 | FEBS Lett. | pmid:9271217 |
Takeda H et al. | Sphingomyelinase and ceramide inhibit formation of F-actin ring in and bone resorption by rabbit mature osteoclasts. | 1998 | FEBS Lett. | pmid:9490019 |
Kiss Z and Deli E | Preferential inhibition of phorbol ester-induced hydrolysis of phosphatidylethanolamine by N-acetylsphingosine in NIH 3T3 fibroblasts. | 1995 | FEBS Lett. | pmid:7781767 |
Shirahama T et al. | Sphingosine induces apoptosis in androgen-independent human prostatic carcinoma DU-145 cells by suppression of bcl-X(L) gene expression. | 1997 | FEBS Lett. | pmid:9141489 |
Takao N et al. | Protective roles for ATM in cellular response to oxidative stress. | 2000 | FEBS Lett. | pmid:10781820 |
Kawano Y et al. | Synergistic effect of interleukin (IL)-1alpha and ceramide analogue on the production of IL-6, IL-8, and macrophage colony-stimulating factor by endometrial stromal cells. | 2004 | Fertil. Steril. | pmid:15474071 |
Kim DK et al. | NF-kappa B mediates the adaptation of human U937 cells to hydrogen peroxide. | 2001 | Free Radic. Biol. Med. | pmid:11182527 |
Taheripak G et al. | Protein tyrosine phosphatase 1B inhibition ameliorates palmitate-induced mitochondrial dysfunction and apoptosis in skeletal muscle cells. | 2013 | Free Radic. Biol. Med. | pmid:24120971 |
d'Anglemont de Tassigny A et al. | Volume-sensitive chloride channels (ICl,vol) mediate doxorubicin-induced apoptosis through apoptotic volume decrease in cardiomyocytes. | 2004 | Fundam Clin Pharmacol | pmid:15482374 |
Conway EM et al. | Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways. | 2002 | Gastroenterology | pmid:12145814 |
Masamune A et al. | Helicobacter pylori-dependent ceramide production may mediate increased interleukin 8 expression in human gastric cancer cell lines. | 1999 | Gastroenterology | pmid:10348816 |
Nickels JT and Broach JR | A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae. | 1996 | Genes Dev. | pmid:8600023 |
Decraene C et al. | Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays. | 2002 | Genome Biol. | pmid:12186649 |
Shayman JA et al. | A turn in the road: How studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A2 with ceramide transacylase activity. | 2004 | Glycoconj. J. | pmid:14973367 |
Navarro P et al. | Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. | 2000 | Growth Horm. IGF Res. | pmid:11042022 |
Stewart CE et al. | Increased, not decreased activation of the insulin-like growth factor (IGF) receptor signalling pathway during ceramide-induced apoptosis. | 1999 | Growth Horm. IGF Res. | pmid:10373346 |
Stoeck A et al. | L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. | 2007 | Gynecol. Oncol. | pmid:17030349 |
Ghahremani M et al. | Activation of Fas ligand/receptor system kills ovarian cancer cell lines by an apoptotic mechanism. | 1998 | Gynecol. Oncol. | pmid:9740705 |
Chen WF et al. | Platelet protease-activated receptor (PAR)4, but not PAR1, associated with neutral sphingomyelinase responsible for thrombin-stimulated ceramide-NF-κB signaling in human platelets. | 2013 | Haematologica | pmid:23065519 |
Jones BE et al. | Ceramide induces caspase-independent apoptosis in rat hepatocytes sensitized by inhibition of RNA synthesis. | 1999 | Hepatology | pmid:10385659 |
Preaux AM et al. | Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2. | 2002 | Hepatology | pmid:12198653 |