N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Gubern A et al. | Lipid droplet biogenesis induced by stress involves triacylglycerol synthesis that depends on group VIA phospholipase A2. | 2009 | J. Biol. Chem. | pmid:19117952 |
Wang J et al. | Potential mechanisms involved in ceramide-induced apoptosis in human colon cancer HT29 cells. | 2009 | Biomed. Environ. Sci. | pmid:19462692 |
Li R et al. | Alpha A-crystallin and alpha B-crystallin, newly identified interaction proteins of protease-activated receptor-2, rescue astrocytes from C2-ceramide- and staurosporine-induced cell death. | 2009 | J. Neurochem. | pmid:19558454 |
Lin YC et al. | Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19435666 |
de Castro e Paula LA and Hansen PJ | Ceramide inhibits development and cytokinesis and induces apoptosis in preimplantation bovine embryos. | 2008 | Mol. Reprod. Dev. | pmid:18157869 |
Miñano A et al. | C2-ceramide mediates cerebellar granule cells apoptosis by activation of caspases-2, -9, and -3. | 2008 | J. Neurosci. Res. | pmid:18311838 |
Zhokhov SS et al. | Bax siRNA promotes survival of cultured and allografted granule cell precursors through blockade of caspase-3 cleavage. | 2008 | Cell Death Differ. | pmid:18323863 |
Nicol GD | Nerve growth factor, sphingomyelins, and sensitization in sensory neurons. | 2008 | Sheng Li Xue Bao | pmid:18958367 |
Lim JY et al. | Investigation on C2-ceramide complexes with transition metal ions using electrospray ionization tandem mass spectrometry. | 2008 | Eur J Mass Spectrom (Chichester, Eng) | pmid:18493098 |
Chen CL et al. | Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. | 2008 | Blood | pmid:18270325 |