N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Cline HT and Constantine-Paton M | The differential influence of protein kinase inhibitors on retinal arbor morphology and eye-specific stripes in the frog retinotectal system. | 1990 | Neuron | pmid:2361013 |
Pitto M et al. | Metabolism of semisynthetic single-chain GM1 derivatives in cerebellar granule cells in culture. | 1991 | Neurochem. Res. | pmid:1815134 |
Kiss Z and Deli E | Regulation of phospholipase D by sphingosine involves both protein kinase C-dependent and -independent mechanisms in NIH 3T3 fibroblasts. | 1992 | Biochem. J. | pmid:1472000 |
Ladenson RC et al. | Utilization of exogenously supplied sphingosine analogues for sphingolipid biosynthesis in Chinese hamster ovary and mouse LM cell fibroblasts. | 1993 | J. Biol. Chem. | pmid:8463295 |
Wong K et al. | N-acetylsphingosine (C2-ceramide) inhibited neutrophil superoxide formation and calcium influx. | 1995 | J. Biol. Chem. | pmid:7852386 |
Jäättelä M et al. | Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. | 1995 | Oncogene | pmid:7540278 |
Sawai H et al. | Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells. | 1995 | J. Biol. Chem. | pmid:7592995 |
Liu R et al. | Effects of sphingosine derivatives on MC3T3-E1 pre-osteoblasts: psychosine elicits release of calcium from intracellualr stores. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7677781 |
Kiss Z and Deli E | Preferential inhibition of phorbol ester-induced hydrolysis of phosphatidylethanolamine by N-acetylsphingosine in NIH 3T3 fibroblasts. | 1995 | FEBS Lett. | pmid:7781767 |