N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Centeno F et al. | Partial lithium-associated protection against apoptosis induced by C2-ceramide in cerebellar granule neurons. | 1998 | Neuroreport | pmid:9926873 |
Soboloff J et al. | Acyl chain length-specific ceramide-induced changes in intracellular Ca2+ concentration and progesterone production are not regulated by tumor necrosis factor alpha in hen granulosa cells. | 1999 | Biol. Reprod. | pmid:9915989 |
Xu FY et al. | N-Acetylsphingosine stimulates phosphatidylglycerolphosphate synthase activity in H9c2 cardiac cells. | 1999 | Biochem. J. | pmid:9895291 |
Reiners JJ and Clift RE | Aryl hydrocarbon receptor regulation of ceramide-induced apoptosis in murine hepatoma 1c1c7 cells. A function independent of aryl hydrocarbon receptor nuclear translocator. | 1999 | J. Biol. Chem. | pmid:9891021 |
MacKichan ML and DeFranco AL | Role of ceramide in lipopolysaccharide (LPS)-induced signaling. LPS increases ceramide rather than acting as a structural homolog. | 1999 | J. Biol. Chem. | pmid:9880559 |
Lauricella M et al. | Increased cyclin E level in retinoblastoma cells during programmed cell death. | 1998 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:9874510 |
Scheid MP et al. | Ceramide and cyclic adenosine monophosphate (cAMP) induce cAMP response element binding protein phosphorylation via distinct signaling pathways while having opposite effects on myeloid cell survival. | 1999 | Blood | pmid:9864164 |
Zheng T et al. | C2-ceramide attenuates prostaglandin F2alpha-induced vasoconstriction and elevation of [Ca2+]i in canine cerebral vascular smooth muscle. | 1998 | Neurosci. Lett. | pmid:9853716 |
Wang P and Bitar KN | Rho A regulates sustained smooth muscle contraction through cytoskeletal reorganization of HSP27. | 1998 | Am. J. Physiol. | pmid:9843784 |
Xia P et al. | Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9826677 |
Soeda S et al. | Tumor necrosis factor-alpha-induced release of plasminogen activator inhibitor-1 from human umbilical vein endothelial cells: involvement of intracellular ceramide signaling event. | 1998 | Biochim. Biophys. Acta | pmid:9824663 |
Cartus T et al. | Distribution of protein phosphatases type 1 and 2A in RINm5F cells. | 1998 | Regul. Pept. | pmid:9809799 |
Ji L et al. | Effects of endoglycoceramidase or D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol on glucose uptake, glycolysis, and mitochondrial respiration in HL60 cells. | 1998 | Arch. Biochem. Biophys. | pmid:9799567 |
Mizushima N et al. | Ceramide, a mediator of interleukin 1, tumour necrosis factor alpha, as well as Fas receptor signalling, induces apoptosis of rheumatoid arthritis synovial cells. | 1998 | Ann. Rheum. Dis. | pmid:9797556 |
Lian JP et al. | Products of sphingolipid catabolism block activation of the p21-activated protein kinases in neutrophils. | 1998 | J. Immunol. | pmid:9780215 |
Birt DF et al. | Inhibition of skin carcinomas but not papillomas by sphingosine, N-methylsphingosine, and N-acetylsphingosine. | 1998 | Nutr Cancer | pmid:9770723 |
Escargueil-Blanc I et al. | Apoptosis and activation of the sphingomyelin-ceramide pathway induced by oxidized low density lipoproteins are not causally related in ECV-304 endothelial cells. | 1998 | J. Biol. Chem. | pmid:9765267 |
Ibitayo AI et al. | Src kinase and PI 3-kinase as a transduction pathway in ceramide-induced contraction of colonic smooth muscle. | 1998 | Am. J. Physiol. | pmid:9756500 |
Mutoh T et al. | Glucosylceramide synthase inhibitor inhibits the action of nerve growth factor in PC12 cells. | 1998 | J. Biol. Chem. | pmid:9748278 |
Vento R et al. | Induction of programmed cell death in human retinoblastoma Y79 cells by C2-ceramide. | 1998 | Mol. Cell. Biochem. | pmid:9746206 |