N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Ramos B et al. | Inhibition of phosphatidylcholine synthesis precedes apoptosis induced by C2-ceramide: protection by exogenous phosphatidylcholine. | 2000 | Neuroreport | pmid:11043531 |
Arboleda G et al. | Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells. | 2007 | Neurosci. Lett. | pmid:17573191 |
Jaramillo-Gómez J et al. | Overexpression of DJ-1 protects against C2-ceramide-induced neuronal death through activation of the PI3K/AKT pathway and inhibition of autophagy. | 2015 | Neurosci. Lett. | pmid:26222260 |
Craighead M et al. | Caspases mediate C2-ceramide-induced apoptosis of the human oligodendroglial cell line, MO3.13. | 2000 | Neurosci. Lett. | pmid:10653009 |
Tavarini S et al. | Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells. | 2000 | Neurosci. Lett. | pmid:10806317 |
Fan C et al. | Autophagy inhibits C2-ceramide-mediated cell death by decreasing the reactive oxygen species levels in SH-SY5Y cells. | 2017 | Neurosci. Lett. | pmid:28288862 |
Zheng T et al. | C2-ceramide attenuates prostaglandin F2alpha-induced vasoconstriction and elevation of [Ca2+]i in canine cerebral vascular smooth muscle. | 1998 | Neurosci. Lett. | pmid:9853716 |
Yang MS et al. | Sphingomyelinase but not ceramide induces nitric oxide synthase expression in rat brain microglia. | 2001 | Neurosci. Lett. | pmid:11567796 |
Tabarean IV et al. | Interleukin-1beta induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons. | 2006 | Neuroscience | pmid:16777343 |
Khodorova A et al. | The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor. | 2017 | Neuroscience | pmid:27826102 |
Willaime-Morawek S et al. | C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis. | 2003 | Neuroscience | pmid:12770554 |
Rojas-Charry L et al. | Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells. | 2014 | Neurotoxicology | pmid:24792327 |
Arboleda G et al. | Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death. | 2010 | Neurotoxicology | pmid:20696185 |
Birt DF et al. | Inhibition of skin carcinomas but not papillomas by sphingosine, N-methylsphingosine, and N-acetylsphingosine. | 1998 | Nutr Cancer | pmid:9770723 |
Shou J et al. | Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. | 2002 | Oncogene | pmid:11840333 |
Deng J et al. | Ceramide does not act as a general second messenger for ultraviolet-induced apoptosis. | 2002 | Oncogene | pmid:11791175 |
Sreenivasan Y et al. | Mechanism of cytosine arabinoside-mediated apoptosis: role of Rel A (p65) dephosphorylation. | 2003 | Oncogene | pmid:12853972 |
Jäättelä M et al. | Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. | 1995 | Oncogene | pmid:7540278 |
Maguer-Satta V et al. | BCR-ABL accelerates C2-ceramide-induced apoptosis. | 1998 | Oncogene | pmid:9464542 |
Mengubas K et al. | Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism. | 1999 | Oncogene | pmid:10229201 |
Takai N et al. | C2-ceramide exhibits antiproliferative activity and potently induces apoptosis in endometrial carcinoma. | 2005 | Oncol. Rep. | pmid:16211298 |
Scholl A et al. | Inhibition of interleukin-1β-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2. | 2016 | Oncotarget | pmid:27556861 |
Ktitorova OV et al. | [Relationship between the induction of MDR1, a multidrug resistance gene in tumor cells, and apoptosis]. | 2001 Jul-Aug | Ontogenez | pmid:11573427 |
Ahmed N and Berridge MV | Ceramides that mediate apoptosis reduce glucose uptake and transporter affinity for glucose in human leukaemic cell lines but not in neutrophils. | 2000 | Pharmacol. Toxicol. | pmid:10752668 |
Bártová E et al. | Apoptotic damage of DNA in human leukaemic HL-60 cells treated with C2-ceramide was detected after G1 blockade of the cell cycle. | 1997 | Physiol Res | pmid:9727507 |
Kim DS et al. | Ceramide inhibits cell proliferation through Akt/PKB inactivation and decreases melanin synthesis in Mel-Ab cells. | 2001 | Pigment Cell Res. | pmid:11310790 |
Yao N et al. | The mitochondrion--an organelle commonly involved in programmed cell death in Arabidopsis thaliana. | 2004 | Plant J. | pmid:15500474 |
Pacheco A et al. | C2-phytoceramide perturbs lipid rafts and cell integrity in Saccharomyces cerevisiae in a sterol-dependent manner. | 2013 | PLoS ONE | pmid:24040213 |
Du WW et al. | Versican G3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and EGFR therapy. | 2011 | PLoS ONE | pmid:22096483 |
Suzuki E et al. | Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15466700 |
Falluel-Morel A et al. | Pituitary adenylate cyclase-activating polypeptide prevents the effects of ceramides on migration, neurite outgrowth, and cytoskeleton remodeling. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15695581 |
De Nadai C et al. | Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10792026 |
Galvan V and Roizman B | Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9520470 |
Xia P et al. | Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9826677 |
Lee JT et al. | Homocysteine induces cerebral endothelial cell death by activating the acid sphingomyelinase ceramide pathway. | 2013 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:23665108 |
Cartus T et al. | Distribution of protein phosphatases type 1 and 2A in RINm5F cells. | 1998 | Regul. Pept. | pmid:9809799 |
Kalo D and Roth Z | Involvement of the sphingolipid ceramide in heat-shock-induced apoptosis of bovine oocytes. | 2011 | Reprod. Fertil. Dev. | pmid:21871207 |
Menné C et al. | T-cell receptor downregulation by ceramide-induced caspase activation and cleavage of the zeta chain. | 2001 | Scand. J. Immunol. | pmid:11169222 |
Scorrano L et al. | BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. | 2003 | Science | pmid:12624178 |
Nicol GD | Nerve growth factor, sphingomyelins, and sensitization in sensory neurons. | 2008 | Sheng Li Xue Bao | pmid:18958367 |
Yoon BS et al. | Optimal suppression of protein phosphatase 2A activity is critical for maintenance of human embryonic stem cell self-renewal. | 2010 | Stem Cells | pmid:20306465 |
Guo L et al. | Sphingosine-1-phosphate inhibits ceramide-induced apoptosis during murine preimplantation embryonic development. | 2013 | Theriogenology | pmid:23731666 |
Sautin Y et al. | Ceramide-induced apoptosis of human thyroid cancer cells resistant to apoptosis by irradiation. | 2000 | Thyroid | pmid:11041449 |
Tomita H et al. | Ceramide-induced cell death in cultured rat retinal pigment epithelial cells. | 2000 | Tohoku J. Exp. Med. | pmid:10778806 |
Hirokawa M et al. | Induction of tissue factor production but not the upregulation of adhesion molecule expression by ceramide in human vascular endothelial cells. | 2000 | Tohoku J. Exp. Med. | pmid:10997557 |
Yang J et al. | C2-ceramide influences alveolar epithelial barrier function by downregulating Zo-1, occludin and claudin-4 expression. | 2017 | Toxicol. Mech. Methods | pmid:28052715 |
Davis MA et al. | Effect of ceramide on intracellular glutathione determines apoptotic or necrotic cell death of JB6 tumor cells. | 2000 | Toxicol. Sci. | pmid:10653520 |
Elner SG et al. | Retinal flavoprotein autofluorescence as a measure of retinal health. | 2008 | Trans Am Ophthalmol Soc | pmid:19277237 |
Zhang H et al. | Ceramide enhances COX-2 expression and VSMC contractile hyperreactivity via ER stress signal activation. | 2017 | Vascul. Pharmacol. | pmid:28797762 |
Zhang XF et al. | [Effect of ceramide on apoptosis of human colon cancer HT-29 cells]. | 2006 | Wei Sheng Yan Jiu | pmid:17086696 |