N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Hollander MC et al. | Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors. | 2001 | Int. J. Cancer | pmid:11241327 |
Hajduch E et al. | Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. | 2001 | Diabetologia | pmid:11270673 |
Frago LM et al. | Short-chain ceramide regulates hepatic methionine adenosyltransferase expression. | 2001 | J. Hepatol. | pmid:11281546 |
Spyridopoulos I et al. | Loss of cyclin A and G1-cell cycle arrest are a prerequisite of ceramide-induced toxicity in human arterial endothelial cells. | 2001 | Cardiovasc. Res. | pmid:11282082 |
Huang C et al. | Involvement of sphingomyelinase in insulin-induced phosphatidylinositol 3-kinase activation. | 2001 | FASEB J. | pmid:11292685 |
Furuya K et al. | Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia. | 2001 | J. Cereb. Blood Flow Metab. | pmid:11295877 |
Kim DS et al. | Ceramide inhibits cell proliferation through Akt/PKB inactivation and decreases melanin synthesis in Mel-Ab cells. | 2001 | Pigment Cell Res. | pmid:11310790 |
Hsu YW et al. | Ceramide inhibits lipopolysaccharide-mediated nitric oxide synthase and cyclooxygenase-2 induction in macrophages: effects on protein kinases and transcription factors. | 2001 | J. Immunol. | pmid:11313375 |
Zhang DX et al. | Ceramide reduces endothelium-dependent vasodilation by increasing superoxide production in small bovine coronary arteries. | 2001 | Circ. Res. | pmid:11325875 |
Vitale N et al. | Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells. | 2001 | EMBO J. | pmid:11350931 |