N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kong JY and Rabkin SW | Mitochondrial effects with ceramide-induced cardiac apoptosis are different from those of palmitate. | 2003 | Arch. Biochem. Biophys. | pmid:12667483 |
Shack S et al. | Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. | 2003 | Mol. Cell. Biol. | pmid:12640124 |
Scorrano L et al. | BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. | 2003 | Science | pmid:12624178 |
Shikata K et al. | Apoptotic activities of C2-ceramide and C2-dihydroceramide homologues against HL-60 cells. | 2003 | Bioorg. Med. Chem. | pmid:12788346 |
Koide N et al. | C2-ceramide inhibits LPS-induced nitric oxide production in RAW 264.7 macrophage cells through down-regulating the activation of Akt. | 2003 | J. Endotoxin Res. | pmid:12803880 |
Siskind LJ et al. | Enlargement and contracture of C2-ceramide channels. | 2003 | Biophys. J. | pmid:12944273 |
Hunsperger EA and Wilcox CL | Caspase-3-dependent reactivation of latent herpes simplex virus type 1 in sensory neuronal cultures. | 2003 | J. Neurovirol. | pmid:12775421 |
Yakushiji K et al. | Characterization of C2-ceramide-resistant HL-60 subline (HL-CR): involvement of PKC delta in C2-ceramide resistance. | 2003 | Exp. Cell Res. | pmid:12749866 |
Perks CM et al. | Prolactin acts as a potent survival factor against C2-ceramide-induced apoptosis in human granulosa cells. | 2003 | Hum. Reprod. | pmid:14645190 |
Enomoto A et al. | Decreased c-Myc expression and its involvement in X-ray-induced apoptotic cell death of human T-cell leukaemia cell line MOLT-4. | 2003 | Int. J. Radiat. Biol. | pmid:14555342 |