N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Lecour S et al. | Ceramide-induced preconditioning involves reactive oxygen species. | 2006 | Life Sci. | pmid:16293265 |
Zhang QH et al. | Redistribution of cytochrome c is not an essential requirement in C2-ceramide induced apoptosis in HL-60 cells. | 1999 | Life Sci. | pmid:10573189 |
Chen JY et al. | Additive effects of C(2)-ceramide on paclitaxel-induced premature senescence of human lung cancer cells. | 2010 | Life Sci. | pmid:20624405 |
Shimada T et al. | Hepatocyte growth factor protects gastric epithelial cells against ceramide-induced apoptosis through induction of cyclooxygenase-2. | 2000 | Life Sci. | pmid:11197751 |
Kuroki J et al. | Cell-permeable ceramide inhibits the growth of B lymphoma Raji cells lacking TNF-alpha-receptors by inducing G0/G1 arrest but not apoptosis: a new model for dissecting cell-cycle arrest and apoptosis. | 1996 | Leukemia | pmid:8946936 |
Cao LC et al. | Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity. | 2004 | Kidney Int. | pmid:15496160 |
Hayashi M et al. | High sensitivity of fibroblast cell lines derived from LEC rats to heat treatment. | 2004 | J. Vet. Med. Sci. | pmid:15528845 |
Zhang J et al. | Impaired Fas-induced apoptosis of T lymphocytes in patients with abdominal aortic aneurysms. | 2007 | J. Vasc. Surg. | pmid:17350784 |
Murase T et al. | Ceramide enhances acrosomal exocytosis triggered by calcium and the calcium ionophore A23187 in boar spermatozoa. | 2004 | J. Reprod. Dev. | pmid:15647619 |
Wang Y et al. | Acid sphingomyelinase mediates 50-Hz magnetic field-induced EGF receptor clustering on lipid raft. | 2016 | J. Recept. Signal Transduct. Res. | pmid:26915736 |
Zhang YH et al. | Ceramide, a putative second messenger for nerve growth factor, modulates the TTX-resistant Na(+) current and delayed rectifier K(+) current in rat sensory neurons. | 2002 | J. Physiol. (Lond.) | pmid:12381813 |
Lu CY et al. | Docosahexaenoic acid down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the sphingomyelinase/ceramide pathway. | 2010 | J. Nutr. Biochem. | pmid:19427778 |
Hunsperger EA and Wilcox CL | Caspase-3-dependent reactivation of latent herpes simplex virus type 1 in sensory neuronal cultures. | 2003 | J. Neurovirol. | pmid:12775421 |
Hatano M et al. | Enhancement of C2-ceramide antitumor activity by small interfering RNA on X chromosome-linked inhibitor of apoptosis protein in resistant human glioma cells. | 2004 | J. Neurosurg. | pmid:15255262 |
Miñano A et al. | C2-ceramide mediates cerebellar granule cells apoptosis by activation of caspases-2, -9, and -3. | 2008 | J. Neurosci. Res. | pmid:18311838 |
Goswami R et al. | Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines. | 2005 | J. Neurosci. Res. | pmid:15968641 |
Toman RE et al. | Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis. | 2002 | J. Neurosci. Res. | pmid:12111862 |
Kimura M et al. | Release of plasminogen activator inhibitor-1 from human astrocytes is regulated by intracellular ceramide. | 2000 | J. Neurosci. Res. | pmid:11107162 |
Keane RW et al. | Activation of CPP32 during apoptosis of neurons and astrocytes. | 1997 | J. Neurosci. Res. | pmid:9130145 |
Mattson MP et al. | Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. | 1997 | J. Neurosci. Res. | pmid:9335256 |
Lobner D | Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis? | 2000 | J. Neurosci. Methods | pmid:10720679 |
Xiao Q et al. | Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia. | 2012 | J. Neurosci. | pmid:23015448 |
Luther JA et al. | Neurotrophins regulate cholinergic synaptic transmission in cultured rat sympathetic neurons through a p75-dependent mechanism. | 2013 | J. Neurophysiol. | pmid:23114219 |
Falluel-Morel A et al. | Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and PACAP through a MAP-kinase-dependent mechanism in cerebellar granule cells. | 2004 | J. Neurochem. | pmid:15569266 |
Blázquez C et al. | The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme. | 1999 | J. Neurochem. | pmid:10098887 |
Aubert N et al. | PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway: involvement of c-Fos in PACAP-induced Bcl-2 expression. | 2006 | J. Neurochem. | pmid:17026529 |
Poppe M et al. | Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression. | 2002 | J. Neurochem. | pmid:12153473 |
Chen S et al. | Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes. | 2006 | J. Neurochem. | pmid:16524368 |
Sabirzhanov B et al. | Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis. | 2012 | J. Neurochem. | pmid:22909049 |
Darios F et al. | Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death. | 2003 | J. Neurochem. | pmid:12562509 |
Schultz A and Larsson C | Ceramide influences neurite outgrowth and neuroblastoma cell apoptosis regulated by novel protein kinase C isoforms. | 2004 | J. Neurochem. | pmid:15189345 |
Wiesner DA and Dawson G | Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway. | 1996 | J. Neurochem. | pmid:8627293 |
Xie H and Johnson GV | Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I. | 1997 | J. Neurochem. | pmid:9282924 |
Rossner S et al. | p75 and TrkA receptor signaling independently regulate amyloid precursor protein mRNA expression, isoform composition, and protein secretion in PC12 cells. | 1998 | J. Neurochem. | pmid:9681467 |
Dawson G et al. | Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death. | 2004 | J. Neurochem. | pmid:15189346 |
Edsall LC et al. | Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. | 2001 | J. Neurochem. | pmid:11238741 |
Pascual M et al. | Ceramide pathways modulate ethanol-induced cell death in astrocytes. | 2003 | J. Neurochem. | pmid:14713309 |
Hartfield PJ et al. | Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells. | 1998 | J. Neurochem. | pmid:9648862 |
Patel M | Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic. | 1998 | J. Neurochem. | pmid:9721731 |
MacPhee I and Barker PA | Extended ceramide exposure activates the trkA receptor by increasing receptor homodimer formation. | 1999 | J. Neurochem. | pmid:10098845 |
Li R and Reiser G | Phosphorylation of Ser45 and Ser59 of αB-crystallin and p38/extracellular regulated kinase activity determine αB-crystallin-mediated protection of rat brain astrocytes from C2-ceramide- and staurosporine-induced cell death. | 2011 | J. Neurochem. | pmid:21615407 |
Cho S and Dawson G | Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells. | 2000 | J. Neurochem. | pmid:10737604 |
Li R et al. | Alpha A-crystallin and alpha B-crystallin, newly identified interaction proteins of protease-activated receptor-2, rescue astrocytes from C2-ceramide- and staurosporine-induced cell death. | 2009 | J. Neurochem. | pmid:19558454 |
Pahan K et al. | Induction of the manganese superoxide dismutase gene by sphingomyelinase and ceramide. | 1999 | J. Neurochem. | pmid:10428046 |
Yoshimura S et al. | Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death. | 1999 | J. Neurochem. | pmid:10428064 |
Sée V et al. | C2-ceramide and reactive oxygen species inhibit pituitary adenylate cyclase activating polypeptide (PACAP)-induced cyclic-AMP-dependent signalling pathway. | 2001 | J. Neurochem. | pmid:11158249 |
Arboleda G et al. | Metabolic activity: a novel indicator of neuronal survival in the murine dopaminergic cell line CAD. | 2005 | J. Mol. Neurosci. | pmid:16055947 |
Sánchez-Mora RM et al. | PINK1 overexpression protects against C2-ceramide-induced CAD cell death through the PI3K/AKT pathway. | 2012 | J. Mol. Neurosci. | pmid:22212487 |
Macchia M et al. | Design, synthesis, and characterization of the antitumor activity of novel ceramide analogues. | 2001 | J. Med. Chem. | pmid:11689086 |
Sakai T et al. | Effects of alpha- and beta-galactosylated C2-ceramides on the immune system. | 1998 | J. Med. Chem. | pmid:9484513 |