N-acetylsphingosine
N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
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Introduction
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with N-acetylsphingosine?
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
PubChem Associated disorders and diseases
What pathways are associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with N-acetylsphingosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with N-acetylsphingosine?
Related references are published most in these journals:
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What lipids are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with N-acetylsphingosine?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with N-acetylsphingosine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ahn EH and Schroeder JJ | Induction of apoptosis by sphingosine, sphinganine, and C(2)-ceramide in human colon cancer cells, but not by C(2)-dihydroceramide. | 2010 | Anticancer Res. | pmid:20683027 |
| Lu CY et al. | Docosahexaenoic acid down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the sphingomyelinase/ceramide pathway. | 2010 | J. Nutr. Biochem. | pmid:19427778 |
| Arboleda G et al. | Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death. | 2010 | Neurotoxicology | pmid:20696185 |
| Abrahan CE et al. | Synthesis of sphingosine is essential for oxidative stress-induced apoptosis of photoreceptors. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:19797232 |
| Chen JY et al. | Additive effects of C(2)-ceramide on paclitaxel-induced premature senescence of human lung cancer cells. | 2010 | Life Sci. | pmid:20624405 |
| Ferrari D et al. | Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19941832 |
| Raucci FJ et al. | Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes. | 2010 | Cardiovasc. Res. | pmid:20008476 |
| Yoon BS et al. | Optimal suppression of protein phosphatase 2A activity is critical for maintenance of human embryonic stem cell self-renewal. | 2010 | Stem Cells | pmid:20306465 |
| Pozuelo-Rubio M | Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. | 2010 | FEBS J. | pmid:20618440 |
| Galluzzi L et al. | miR-181a and miR-630 regulate cisplatin-induced cancer cell death. | 2010 | Cancer Res. | pmid:20145152 |