N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Maguer-Satta V et al. | BCR-ABL accelerates C2-ceramide-induced apoptosis. | 1998 | Oncogene | pmid:9464542 |
Tanabe F et al. | Ceramide promotes calpain-mediated proteolysis of protein kinase C beta in murine polymorphonuclear leukocytes. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9439623 |
Kishida E et al. | Distinctive inhibitory activity of docosahexaenoic acid against sphingosine-induced apoptosis. | 1998 | Biochim. Biophys. Acta | pmid:9555103 |
Mutoh T et al. | Glucosylceramide synthase inhibitor inhibits the action of nerve growth factor in PC12 cells. | 1998 | J. Biol. Chem. | pmid:9748278 |
Cartus T et al. | Distribution of protein phosphatases type 1 and 2A in RINm5F cells. | 1998 | Regul. Pept. | pmid:9809799 |
Birt DF et al. | Inhibition of skin carcinomas but not papillomas by sphingosine, N-methylsphingosine, and N-acetylsphingosine. | 1998 | Nutr Cancer | pmid:9770723 |
Lakics V and Vogel SN | Lipopolysaccharide and ceramide use divergent signaling pathways to induce cell death in murine macrophages. | 1998 | J. Immunol. | pmid:9725248 |
Hama-Inaba H et al. | Radio-sensitive murine thymoma cell line 3SB: characterization of its apoptosis-resistant variants induced by repeated X-irradiation. | 1998 | Mutat. Res. | pmid:9726009 |
Ghahremani M et al. | Activation of Fas ligand/receptor system kills ovarian cancer cell lines by an apoptotic mechanism. | 1998 | Gynecol. Oncol. | pmid:9740705 |
Alesse E et al. | The growth arrest and downregulation of c-myc transcription induced by ceramide are related events dependent on p21 induction, Rb underphosphorylation and E2F sequestering. | 1998 | Cell Death Differ. | pmid:10200487 |