N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Nicol GD | Nerve growth factor, sphingomyelins, and sensitization in sensory neurons. | 2008 | Sheng Li Xue Bao | pmid:18958367 |
Lim JY et al. | Investigation on C2-ceramide complexes with transition metal ions using electrospray ionization tandem mass spectrometry. | 2008 | Eur J Mass Spectrom (Chichester, Eng) | pmid:18493098 |
Arboleda G et al. | Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells. | 2007 | Neurosci. Lett. | pmid:17573191 |
Adachi T et al. | Membrane microdomain formation is crucial in epiboly during gastrulation of medaka. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17511962 |
Kim S et al. | Design, synthesis, and preliminary biological evaluation of a novel triazole analogue of ceramide. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17561396 |
Arboleda G et al. | Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells. | 2007 | Eur. J. Neurosci. | pmid:17561816 |
Zhang J et al. | Impaired Fas-induced apoptosis of T lymphocytes in patients with abdominal aortic aneurysms. | 2007 | J. Vasc. Surg. | pmid:17350784 |
Abe A et al. | The acylation of lipophilic alcohols by lysosomal phospholipase A2. | 2007 | J. Lipid Res. | pmid:17626977 |
JeBailey L et al. | Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells. | 2007 | Diabetes | pmid:17259384 |
Zhang TH et al. | Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinases. | 2007 | Acta Pharmacol. Sin. | pmid:17303009 |