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TNFalpha enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation. |
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2001 |
Mol. Biol. Cell |
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2001 |
Cancer Res. |
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Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis. |
2001 |
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2001 |
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2001 |
EMBO J. |
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Uncoupling protein-3 mRNA up-regulation in C2C12 myotubes after etomoxir treatment. |
2001 |
Biochim. Biophys. Acta |
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Kawano Y et al. |
Synergistic effect of interleukin-1alpha and ceramide analogue on production of prostaglandin E2 and F2alpha by endometrial stromal cells. |
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Tumor necrosis factor-alpha, sphingomyelinase and ceramides activate tyrosine kinase, p21Ras and phosphatidylinositol 3-kinase: implications for glucose transport and insulin resistance. |
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Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia. |
2001 |
J. Cereb. Blood Flow Metab. |
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Ceramide reduces endothelium-dependent vasodilation by increasing superoxide production in small bovine coronary arteries. |
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2001 |
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2001 |
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Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. |
2001 |
Diabetologia |
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2001 |
Arch. Biochem. Biophys. |
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2001 |
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Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases. |
2001 |
Brain Res. |
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The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. |
2001 |
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2001 |
Free Radic. Biol. Med. |
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Ceramide inhibition of mammalian phospholipase D1 and D2 activities is antagonized by phosphatidylinositol 4,5-bisphosphate. |
2001 |
Biochemistry |
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2001 |
Eur. J. Paediatr. Neurol. |
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Cell cycle arrest of hematopoietic cell lines after treatment with ceramide is commonly associated with retinoblastoma activation. |
2001 |
Cytometry |
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The protective effect of ceramide in immature rat brain hypoxia-ischemia involves up-regulation of bcl-2 and reduction of TUNEL-positive cells. |
2001 |
J. Cereb. Blood Flow Metab. |
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Int. J. Cancer |
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2001 |
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Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. |
2001 |
Cancer Res. |
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Int. J. Dev. Neurosci. |
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2000 |
Biochim. Biophys. Acta |
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Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage. |
2000 |
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Biochem. J. |
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Release of plasminogen activator inhibitor-1 from human astrocytes is regulated by intracellular ceramide. |
2000 |
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Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. |
2000 |
Growth Horm. IGF Res. |
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Inhibition of phosphatidylcholine synthesis precedes apoptosis induced by C2-ceramide: protection by exogenous phosphatidylcholine. |
2000 |
Neuroreport |
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Ceramide 2 (N-acetyl sphingosine) is associated with reduction in Bcl-2 protein levels by Western blotting and with apoptosis in cultured human keratinocytes. |
2000 |
Br. J. Dermatol. |
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Sphingolipids and cholesterol modulate membrane susceptibility to cytosolic phospholipase A(2). |
2000 |
J. Lipid Res. |
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Ceramides induce apoptosis in HeLa cells and enhance cytochrome c-induced apoptosis in Xenopus egg extracts. |
2000 |
Cell. Mol. Life Sci. |
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Mitochondrial free calcium levels (Rhod-2 fluorescence) and ultrastructural alterations in neuronally differentiated PC12 cells during ceramide-dependent cell death. |
2000 |
J. Comp. Neurol. |
pmid:10982470
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Ceramide does not inhibit protein kinase C beta-dependent phospholipase D activity stimulated by anti-Fas monoclonal antibody in A20 cells. |
2000 |
Cell. Signal. |
pmid:11152958
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