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TNFalpha enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation. |
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2001 |
Mol. Biol. Cell |
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2001 |
Cancer Res. |
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Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis. |
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2001 |
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2001 |
EMBO J. |
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Uncoupling protein-3 mRNA up-regulation in C2C12 myotubes after etomoxir treatment. |
2001 |
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2001 |
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2001 |
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2001 |
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2001 |
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Ceramide inhibits cell proliferation through Akt/PKB inactivation and decreases melanin synthesis in Mel-Ab cells. |
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2001 |
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Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. |
2001 |
Diabetologia |
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2001 |
Arch. Biochem. Biophys. |
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2001 |
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Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases. |
2001 |
Brain Res. |
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The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. |
2001 |
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2001 |
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Ceramide inhibition of mammalian phospholipase D1 and D2 activities is antagonized by phosphatidylinositol 4,5-bisphosphate. |
2001 |
Biochemistry |
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Cell cycle arrest of hematopoietic cell lines after treatment with ceramide is commonly associated with retinoblastoma activation. |
2001 |
Cytometry |
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The protective effect of ceramide in immature rat brain hypoxia-ischemia involves up-regulation of bcl-2 and reduction of TUNEL-positive cells. |
2001 |
J. Cereb. Blood Flow Metab. |
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2001 |
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t-SNARE dephosphorylation promotes SNARE assembly and exocytosis in yeast. |
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C2-ceramide and reactive oxygen species inhibit pituitary adenylate cyclase activating polypeptide (PACAP)-induced cyclic-AMP-dependent signalling pathway. |
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Mechanisms of apoptosis in embryonic cortical neurons (E6 and E7) in culture involve lipid signalling, protein phosphorylation and caspase activation. |
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2000 |
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J. Cell. Sci. |
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The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosis. |
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J. Biol. Chem. |
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Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells. |
2000 |
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Ceramide-mediated stimulation of inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation in murine macrophages requires tyrosine kinase activity. |
2000 |
J. Leukoc. Biol. |
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Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. |
2000 |
Proc. Natl. Acad. Sci. U.S.A. |
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Tumor necrosis factor-alpha-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts. |
2000 |
J. Cell. Physiol. |
pmid:10797307
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Ceramides that mediate apoptosis reduce glucose uptake and transporter affinity for glucose in human leukaemic cell lines but not in neutrophils. |
2000 |
Pharmacol. Toxicol. |
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Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l -cysteine. |
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J. Neurochem. |
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Meth. Enzymol. |
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FEBS Lett. |
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