N-acetylsphingosine

N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.

Cross Reference

Introduction

To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with N-acetylsphingosine?

N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine

MeSH term MeSH ID Detail
Insulin Resistance D007333 99 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Lung Neoplasms D008175 171 associated lipids
Per page 10 20 50 | Total 26

PubChem Associated disorders and diseases

What pathways are associated with N-acetylsphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with N-acetylsphingosine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with N-acetylsphingosine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with N-acetylsphingosine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with N-acetylsphingosine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with N-acetylsphingosine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with N-acetylsphingosine

Download all related citations
Per page 10 20 50 100 | Total 506
Authors Title Published Journal PubMed Link
Sugiki H et al. C2-ceramide induces apoptosis in a human squamous cell carcinoma cell line. 2000 Br. J. Dermatol. pmid:11122015
Menné C et al. Ceramide-induced TCR up-regulation. 2000 J. Immunol. pmid:10975817
Kim HS et al. Induction of apoptosis by all-trans-retinoic acid and C2-ceramide treatment in rat stromal-vascular cultures. 2000 Biochem. Biophys. Res. Commun. pmid:10733907
Fukunaga T et al. Implication of sphingolipid metabolism in the stability of the Golgi apparatus. 2000 J. Cell. Sci. pmid:10954427
Ogura M and Handa S Induction of apoptosis by novel synthesized acylamides of human lymphocytes. 2000 Biochim. Biophys. Acta pmid:10601700
Young KW et al. Effect of dimethylsphingosine on muscarinic M(3) receptor signalling in SH-SY5Y cells. 2000 Eur. J. Pharmacol. pmid:10940357
Craighead M et al. Caspases mediate C2-ceramide-induced apoptosis of the human oligodendroglial cell line, MO3.13. 2000 Neurosci. Lett. pmid:10653009
Davis MA et al. Effect of ceramide on intracellular glutathione determines apoptotic or necrotic cell death of JB6 tumor cells. 2000 Toxicol. Sci. pmid:10653520
Enomoto A et al. Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human T-cell leukemia cell line MOLT-4. 2000 Cancer Lett. pmid:10822128
Posey SC et al. Failure of gelsolin overexpression to regulate lymphocyte apoptosis. 2000 Blood pmid:10828033
Siskind LJ and Colombini M The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosis. 2000 J. Biol. Chem. pmid:11027675
Chan C and Goldkorn T Ceramide path in human lung cell death. 2000 Am. J. Respir. Cell Mol. Biol. pmid:10745027
Brás A et al. Ceramide-induced cell death is independent of the Fas/Fas ligand pathway and is prevented by Nur77 overexpression in A20 B cells. 2000 Cell Death Differ. pmid:10745271
Paolucci C et al. Nitric oxide inhibits the tumor necrosis factor alpha -regulated endocytosis of human dendritic cells in a cyclic GMP-dependent way. 2000 J. Biol. Chem. pmid:10777484
Tomita H et al. Ceramide-induced cell death in cultured rat retinal pigment epithelial cells. 2000 Tohoku J. Exp. Med. pmid:10778806
Raisova M et al. Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release. 2000 FEBS Lett. pmid:10802053
Tavarini S et al. Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells. 2000 Neurosci. Lett. pmid:10806317
Knapp KM and English BK Ceramide-mediated stimulation of inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation in murine macrophages requires tyrosine kinase activity. 2000 J. Leukoc. Biol. pmid:10811015
De Nadai C et al. Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10792026
Meadows KA et al. Tumor necrosis factor-alpha-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts. 2000 J. Cell. Physiol. pmid:10797307
Ahmed N and Berridge MV Ceramides that mediate apoptosis reduce glucose uptake and transporter affinity for glucose in human leukaemic cell lines but not in neutrophils. 2000 Pharmacol. Toxicol. pmid:10752668
Yeh MW et al. Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l -cysteine. 2000 J. Immunol. pmid:10754324
Cheng S et al. Filopodial behavior is dependent on the phosphorylation state of neuronal growth cones. 2000 Cell Motil. Cytoskeleton pmid:11093253
Kimura M et al. Release of plasminogen activator inhibitor-1 from human astrocytes is regulated by intracellular ceramide. 2000 J. Neurosci. Res. pmid:11107162
Navarro P et al. Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. 2000 Growth Horm. IGF Res. pmid:11042022
Ramos B et al. Inhibition of phosphatidylcholine synthesis precedes apoptosis induced by C2-ceramide: protection by exogenous phosphatidylcholine. 2000 Neuroreport pmid:11043531
Zhou H et al. Akt regulates cell survival and apoptosis at a postmitochondrial level. 2000 J. Cell Biol. pmid:11062251
O'Byrne D and Sansom D Lack of costimulation by both sphingomyelinase and C2 ceramide in resting human T cells. 2000 Immunology pmid:10886399
Campbell V and Lynch MA The role of ceramide in the modulation of intracellular Ca2+ levels by interleukin 1 beta in rat cortical synaptosomes. 2000 Cytokine pmid:10857764
Chae HJ et al. Dexamethasone suppresses tumor necrosis factor-alpha-induced apoptosis in osteoblasts: possible role for ceramide. 2000 Endocrinology pmid:10919278
Galve-Roperh I et al. Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. 2000 Nat. Med. pmid:10700234
Lobner D Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis? 2000 J. Neurosci. Methods pmid:10720679
Kondo T et al. Suppression of heat shock protein-70 by ceramide in heat shock-induced HL-60 cell apoptosis. 2000 J. Biol. Chem. pmid:10722733
Tsushima H and Mori M In vivo evidence that activation of tyrosine kinase is a trigger for lipopolysaccharide-induced fever in rats. 2000 Brain Res. pmid:10678764
Mihai R et al. C2-Ceramide increases cytoplasmic calcium concentrations in human parathyroid cells. 2000 Biochem. Biophys. Res. Commun. pmid:10679256
Salinas M et al. Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells. 2000 Mol. Cell. Neurosci. pmid:10673324
Migita K et al. Regulation of rheumatoid synovial cell growth by ceramide. 2000 Biochem. Biophys. Res. Commun. pmid:10694479
Cho S and Dawson G Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells. 2000 J. Neurochem. pmid:10737604
Shayman JA and Abe A 1-O-acylceramide synthase. 2000 Meth. Enzymol. pmid:10563315
Chen JS et al. Regulation of phospholipase D activity and ceramide production in daunorubicin-induced apoptosis in A-431 cells. 2000 Biochim. Biophys. Acta pmid:11082532
Takao N et al. Protective roles for ATM in cellular response to oxidative stress. 2000 FEBS Lett. pmid:10781820
Shimada T et al. Hepatocyte growth factor protects gastric epithelial cells against ceramide-induced apoptosis through induction of cyclooxygenase-2. 2000 Life Sci. pmid:11197751
Han J and Shin I Ceramide does not inhibit protein kinase C beta-dependent phospholipase D activity stimulated by anti-Fas monoclonal antibody in A20 cells. 2000 Cell. Signal. pmid:11152958
Sautin Y et al. Ceramide-induced apoptosis of human thyroid cancer cells resistant to apoptosis by irradiation. 2000 Thyroid pmid:11041449
Meroni SB et al. Effect of N-acetylsphingosine (C2) and the ceramidase inhibitor (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol on the regulation of Sertoli cell function. 1999 Sep-Oct J. Androl. pmid:10520574
Abend M et al. Indications for an active process underlying spontaneous and radiation-induced micronucleation in L929 cells. 1999 Int. J. Radiat. Biol. pmid:10622263
Medvedev AE et al. Limited role of ceramide in lipopolysaccharide-mediated mitogen-activated protein kinase activation, transcription factor induction, and cytokine release. 1999 J. Biol. Chem. pmid:10092612
Mahajan S et al. Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamide]. 1999 J. Biol. Chem. pmid:10092645
MacPhee I and Barker PA Extended ceramide exposure activates the trkA receptor by increasing receptor homodimer formation. 1999 J. Neurochem. pmid:10098845
Puranam KL et al. CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide. 1999 Mol. Genet. Metab. pmid:10191118