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Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells. |
2001 |
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2001 |
Scand. J. Immunol. |
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TNFalpha enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation. |
2001 |
Exp. Cell Res. |
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Hanna AN et al. |
Tumor necrosis factor-alpha induces stress fiber formation through ceramide production: role of sphingosine kinase. |
2001 |
Mol. Biol. Cell |
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Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids. |
2001 |
Cancer Res. |
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Ghosh Choudhury G et al. |
Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis. |
2001 |
Biochem. Biophys. Res. Commun. |
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C2-ceramide signaling in glioma cells: synergistic enhancement of CD95-mediated, caspase-dependent apoptosis. |
2001 |
Cell Death Differ. |
pmid:11536010
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Propagation of the apoptotic signal by mitochondrial waves. |
2001 |
EMBO J. |
pmid:11483514
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Cabrero A et al. |
Uncoupling protein-3 mRNA up-regulation in C2C12 myotubes after etomoxir treatment. |
2001 |
Biochim. Biophys. Acta |
pmid:11470240
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Kawano Y et al. |
Synergistic effect of interleukin-1alpha and ceramide analogue on production of prostaglandin E2 and F2alpha by endometrial stromal cells. |
2001 |
Am. J. Reprod. Immunol. |
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Kajimoto T et al. |
Subtype-specific translocation of the delta subtype of protein kinase C and its activation by tyrosine phosphorylation induced by ceramide in HeLa cells. |
2001 |
Mol. Cell. Biol. |
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Design, synthesis, and characterization of the antitumor activity of novel ceramide analogues. |
2001 |
J. Med. Chem. |
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Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia. |
2001 |
J. Cereb. Blood Flow Metab. |
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Ceramide reduces endothelium-dependent vasodilation by increasing superoxide production in small bovine coronary arteries. |
2001 |
Circ. Res. |
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Short-chain ceramide regulates hepatic methionine adenosyltransferase expression. |
2001 |
J. Hepatol. |
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Loss of cyclin A and G1-cell cycle arrest are a prerequisite of ceramide-induced toxicity in human arterial endothelial cells. |
2001 |
Cardiovasc. Res. |
pmid:11282082
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Ceramide inhibits cell proliferation through Akt/PKB inactivation and decreases melanin synthesis in Mel-Ab cells. |
2001 |
Pigment Cell Res. |
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Ceramide inhibits lipopolysaccharide-mediated nitric oxide synthase and cyclooxygenase-2 induction in macrophages: effects on protein kinases and transcription factors. |
2001 |
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2001 |
EMBO J. |
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Effects of ceramide on aggrecanase activity in rabbit articular cartilage. |
2001 |
Biochem. Biophys. Res. Commun. |
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Involvement of sphingomyelinase in insulin-induced phosphatidylinositol 3-kinase activation. |
2001 |
FASEB J. |
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Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. |
2001 |
Diabetologia |
pmid:11270673
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Caspase-resistant vimentin suppresses apoptosis after photodynamic treatment with a silicon phthalocyanine in Jurkat cells. |
2001 |
Arch. Biochem. Biophys. |
pmid:11368515
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Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation. |
2001 |
Eur. J. Neurosci. |
pmid:11422444
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Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases. |
2001 |
Brain Res. |
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The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. |
2001 |
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Angiostatin effects on endothelial cells mediated by ceramide and RhoA. |
2001 |
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NF-kappa B mediates the adaptation of human U937 cells to hydrogen peroxide. |
2001 |
Free Radic. Biol. Med. |
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Ceramide inhibition of mammalian phospholipase D1 and D2 activities is antagonized by phosphatidylinositol 4,5-bisphosphate. |
2001 |
Biochemistry |
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2001 |
J. Neurochem. |
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2001 |
Int. J. Cancer |
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Sphingomyelinase but not ceramide induces nitric oxide synthase expression in rat brain microglia. |
2001 |
Neurosci. Lett. |
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Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells. |
2001 |
Mol. Pharmacol. |
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Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. |
2001 |
Cancer Res. |
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Marash M and Gerst JE |
t-SNARE dephosphorylation promotes SNARE assembly and exocytosis in yeast. |
2001 |
EMBO J. |
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C2-ceramide and reactive oxygen species inhibit pituitary adenylate cyclase activating polypeptide (PACAP)-induced cyclic-AMP-dependent signalling pathway. |
2001 |
J. Neurochem. |
pmid:11158249
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Mechanisms of apoptosis in embryonic cortical neurons (E6 and E7) in culture involve lipid signalling, protein phosphorylation and caspase activation. |
2000 Apr-Jun |
Int. J. Dev. Neurosci. |
pmid:10715579
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Induction of apoptosis by novel synthesized acylamides of human lymphocytes. |
2000 |
Biochim. Biophys. Acta |
pmid:10601700
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Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage. |
2000 |
Biochem. Biophys. Res. Commun. |
pmid:10623638
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Requirement of calmodulin binding by HIV-1 gp160 for enhanced FAS-mediated apoptosis. |
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J. Biol. Chem. |
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2000 |
Biochem. J. |
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Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-alpha and ceramide. |
2000 |
Am. J. Physiol., Cell Physiol. |
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Inhibition of phosphatidylcholine synthesis precedes apoptosis induced by C2-ceramide: protection by exogenous phosphatidylcholine. |
2000 |
Neuroreport |
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Akt regulates cell survival and apoptosis at a postmitochondrial level. |
2000 |
J. Cell Biol. |
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Ceramide 2 (N-acetyl sphingosine) is associated with reduction in Bcl-2 protein levels by Western blotting and with apoptosis in cultured human keratinocytes. |
2000 |
Br. J. Dermatol. |
pmid:10971319
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Sphingolipids and cholesterol modulate membrane susceptibility to cytosolic phospholipase A(2). |
2000 |
J. Lipid Res. |
pmid:11013311
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Jiang Z et al. |
Ceramides induce apoptosis in HeLa cells and enhance cytochrome c-induced apoptosis in Xenopus egg extracts. |
2000 |
Cell. Mol. Life Sci. |
pmid:10961348
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Pahlavani MA and Vargas DM |
The effect of a ceramide analog, N-acetylsphingosine on the induction of proliferation and IL-2 synthesis in T cells from young and old F344 rats. |
2000 |
Immunopharmacology |
pmid:10996032
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Hirokawa M et al. |
Induction of tissue factor production but not the upregulation of adhesion molecule expression by ceramide in human vascular endothelial cells. |
2000 |
Tohoku J. Exp. Med. |
pmid:10997557
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Mitochondrial free calcium levels (Rhod-2 fluorescence) and ultrastructural alterations in neuronally differentiated PC12 cells during ceramide-dependent cell death. |
2000 |
J. Comp. Neurol. |
pmid:10982470
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