N-acetylsphingosine

N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.

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Introduction

To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with N-acetylsphingosine?

N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine

MeSH term MeSH ID Detail
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Helicobacter Infections D016481 21 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with N-acetylsphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with N-acetylsphingosine?

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Location Cross reference Weighted score Related literatures
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What functions are associated with N-acetylsphingosine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with N-acetylsphingosine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with N-acetylsphingosine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with N-acetylsphingosine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with N-acetylsphingosine

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Authors Title Published Journal PubMed Link
Migita K et al. Regulation of rheumatoid synovial cell growth by ceramide. 2000 Biochem. Biophys. Res. Commun. pmid:10694479
Galve-Roperh I et al. Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. 2000 Nat. Med. pmid:10700234
Dawson G Mechanisms of apoptosis in embryonic cortical neurons (E6 and E7) in culture involve lipid signalling, protein phosphorylation and caspase activation. 2000 Apr-Jun Int. J. Dev. Neurosci. pmid:10715579
Lobner D Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis? 2000 J. Neurosci. Methods pmid:10720679
Kondo T et al. Suppression of heat shock protein-70 by ceramide in heat shock-induced HL-60 cell apoptosis. 2000 J. Biol. Chem. pmid:10722733
Kim HS et al. Induction of apoptosis by all-trans-retinoic acid and C2-ceramide treatment in rat stromal-vascular cultures. 2000 Biochem. Biophys. Res. Commun. pmid:10733907
Cho S and Dawson G Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells. 2000 J. Neurochem. pmid:10737604
Chan C and Goldkorn T Ceramide path in human lung cell death. 2000 Am. J. Respir. Cell Mol. Biol. pmid:10745027
Brás A et al. Ceramide-induced cell death is independent of the Fas/Fas ligand pathway and is prevented by Nur77 overexpression in A20 B cells. 2000 Cell Death Differ. pmid:10745271
Ahmed N and Berridge MV Ceramides that mediate apoptosis reduce glucose uptake and transporter affinity for glucose in human leukaemic cell lines but not in neutrophils. 2000 Pharmacol. Toxicol. pmid:10752668