| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
N-acetylsphingosine
N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
Cross Reference
Introduction
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with N-acetylsphingosine?
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
PubChem Associated disorders and diseases
What pathways are associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with N-acetylsphingosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with N-acetylsphingosine?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with N-acetylsphingosine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sugiki H et al. | C2-ceramide induces apoptosis in a human squamous cell carcinoma cell line. | 2000 | Br. J. Dermatol. | pmid:11122015 |
| Menné C et al. | Ceramide-induced TCR up-regulation. | 2000 | J. Immunol. | pmid:10975817 |
| Kim HS et al. | Induction of apoptosis by all-trans-retinoic acid and C2-ceramide treatment in rat stromal-vascular cultures. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10733907 |
| Fukunaga T et al. | Implication of sphingolipid metabolism in the stability of the Golgi apparatus. | 2000 | J. Cell. Sci. | pmid:10954427 |
| Ogura M and Handa S | Induction of apoptosis by novel synthesized acylamides of human lymphocytes. | 2000 | Biochim. Biophys. Acta | pmid:10601700 |
| Young KW et al. | Effect of dimethylsphingosine on muscarinic M(3) receptor signalling in SH-SY5Y cells. | 2000 | Eur. J. Pharmacol. | pmid:10940357 |
| Craighead M et al. | Caspases mediate C2-ceramide-induced apoptosis of the human oligodendroglial cell line, MO3.13. | 2000 | Neurosci. Lett. | pmid:10653009 |
| Davis MA et al. | Effect of ceramide on intracellular glutathione determines apoptotic or necrotic cell death of JB6 tumor cells. | 2000 | Toxicol. Sci. | pmid:10653520 |
| Enomoto A et al. | Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human T-cell leukemia cell line MOLT-4. | 2000 | Cancer Lett. | pmid:10822128 |
| Posey SC et al. | Failure of gelsolin overexpression to regulate lymphocyte apoptosis. | 2000 | Blood | pmid:10828033 |
| Siskind LJ and Colombini M | The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosis. | 2000 | J. Biol. Chem. | pmid:11027675 |
| Chan C and Goldkorn T | Ceramide path in human lung cell death. | 2000 | Am. J. Respir. Cell Mol. Biol. | pmid:10745027 |
| Brás A et al. | Ceramide-induced cell death is independent of the Fas/Fas ligand pathway and is prevented by Nur77 overexpression in A20 B cells. | 2000 | Cell Death Differ. | pmid:10745271 |
| Paolucci C et al. | Nitric oxide inhibits the tumor necrosis factor alpha -regulated endocytosis of human dendritic cells in a cyclic GMP-dependent way. | 2000 | J. Biol. Chem. | pmid:10777484 |
| Tomita H et al. | Ceramide-induced cell death in cultured rat retinal pigment epithelial cells. | 2000 | Tohoku J. Exp. Med. | pmid:10778806 |
| Raisova M et al. | Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release. | 2000 | FEBS Lett. | pmid:10802053 |
| Tavarini S et al. | Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells. | 2000 | Neurosci. Lett. | pmid:10806317 |
| Knapp KM and English BK | Ceramide-mediated stimulation of inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation in murine macrophages requires tyrosine kinase activity. | 2000 | J. Leukoc. Biol. | pmid:10811015 |
| De Nadai C et al. | Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10792026 |
| Meadows KA et al. | Tumor necrosis factor-alpha-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts. | 2000 | J. Cell. Physiol. | pmid:10797307 |
| Ahmed N and Berridge MV | Ceramides that mediate apoptosis reduce glucose uptake and transporter affinity for glucose in human leukaemic cell lines but not in neutrophils. | 2000 | Pharmacol. Toxicol. | pmid:10752668 |
| Yeh MW et al. | Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l -cysteine. | 2000 | J. Immunol. | pmid:10754324 |
| Cheng S et al. | Filopodial behavior is dependent on the phosphorylation state of neuronal growth cones. | 2000 | Cell Motil. Cytoskeleton | pmid:11093253 |
| Kimura M et al. | Release of plasminogen activator inhibitor-1 from human astrocytes is regulated by intracellular ceramide. | 2000 | J. Neurosci. Res. | pmid:11107162 |
| Navarro P et al. | Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. | 2000 | Growth Horm. IGF Res. | pmid:11042022 |
| Ramos B et al. | Inhibition of phosphatidylcholine synthesis precedes apoptosis induced by C2-ceramide: protection by exogenous phosphatidylcholine. | 2000 | Neuroreport | pmid:11043531 |
| Zhou H et al. | Akt regulates cell survival and apoptosis at a postmitochondrial level. | 2000 | J. Cell Biol. | pmid:11062251 |
| O'Byrne D and Sansom D | Lack of costimulation by both sphingomyelinase and C2 ceramide in resting human T cells. | 2000 | Immunology | pmid:10886399 |
| Campbell V and Lynch MA | The role of ceramide in the modulation of intracellular Ca2+ levels by interleukin 1 beta in rat cortical synaptosomes. | 2000 | Cytokine | pmid:10857764 |
| Chae HJ et al. | Dexamethasone suppresses tumor necrosis factor-alpha-induced apoptosis in osteoblasts: possible role for ceramide. | 2000 | Endocrinology | pmid:10919278 |
| Galve-Roperh I et al. | Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. | 2000 | Nat. Med. | pmid:10700234 |
| Lobner D | Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis? | 2000 | J. Neurosci. Methods | pmid:10720679 |
| Kondo T et al. | Suppression of heat shock protein-70 by ceramide in heat shock-induced HL-60 cell apoptosis. | 2000 | J. Biol. Chem. | pmid:10722733 |
| Tsushima H and Mori M | In vivo evidence that activation of tyrosine kinase is a trigger for lipopolysaccharide-induced fever in rats. | 2000 | Brain Res. | pmid:10678764 |
| Mihai R et al. | C2-Ceramide increases cytoplasmic calcium concentrations in human parathyroid cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10679256 |
| Salinas M et al. | Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells. | 2000 | Mol. Cell. Neurosci. | pmid:10673324 |
| Migita K et al. | Regulation of rheumatoid synovial cell growth by ceramide. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10694479 |
| Cho S and Dawson G | Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells. | 2000 | J. Neurochem. | pmid:10737604 |
| Shayman JA and Abe A | 1-O-acylceramide synthase. | 2000 | Meth. Enzymol. | pmid:10563315 |
| Chen JS et al. | Regulation of phospholipase D activity and ceramide production in daunorubicin-induced apoptosis in A-431 cells. | 2000 | Biochim. Biophys. Acta | pmid:11082532 |
| Takao N et al. | Protective roles for ATM in cellular response to oxidative stress. | 2000 | FEBS Lett. | pmid:10781820 |
| Shimada T et al. | Hepatocyte growth factor protects gastric epithelial cells against ceramide-induced apoptosis through induction of cyclooxygenase-2. | 2000 | Life Sci. | pmid:11197751 |
| Han J and Shin I | Ceramide does not inhibit protein kinase C beta-dependent phospholipase D activity stimulated by anti-Fas monoclonal antibody in A20 cells. | 2000 | Cell. Signal. | pmid:11152958 |
| Sautin Y et al. | Ceramide-induced apoptosis of human thyroid cancer cells resistant to apoptosis by irradiation. | 2000 | Thyroid | pmid:11041449 |
| Meroni SB et al. | Effect of N-acetylsphingosine (C2) and the ceramidase inhibitor (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol on the regulation of Sertoli cell function. | 1999 Sep-Oct | J. Androl. | pmid:10520574 |
| Abend M et al. | Indications for an active process underlying spontaneous and radiation-induced micronucleation in L929 cells. | 1999 | Int. J. Radiat. Biol. | pmid:10622263 |
| MacPhee I and Barker PA | Extended ceramide exposure activates the trkA receptor by increasing receptor homodimer formation. | 1999 | J. Neurochem. | pmid:10098845 |
| Puranam KL et al. | CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide. | 1999 | Mol. Genet. Metab. | pmid:10191118 |
| Su X et al. | Differential activation of phosphoinositide 3-kinase by endothelin and ceramide in colonic smooth muscle cells. | 1999 | Am. J. Physiol. | pmid:10198327 |
| Kovács P et al. | Effect of C2 ceramide on the inositol phospholipid metabolism (uptake of 32P, 3H-serine and 3H-palmitic acid) and apoptosis-related morphological changes in Tetrahymena. | 1999 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:10190048 |