N-acetylsphingosine

N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.

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Introduction

To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with N-acetylsphingosine?

N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine

MeSH term MeSH ID Detail
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Helicobacter Infections D016481 21 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with N-acetylsphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with N-acetylsphingosine?

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Location Cross reference Weighted score Related literatures
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What functions are associated with N-acetylsphingosine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with N-acetylsphingosine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with N-acetylsphingosine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with N-acetylsphingosine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with N-acetylsphingosine

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Authors Title Published Journal PubMed Link
Kinscherf R et al. Apoptosis caused by oxidized LDL is manganese superoxide dismutase and p53 dependent. 1998 FASEB J. pmid:9535218
Sakai T et al. Effects of alpha- and beta-galactosylated C2-ceramides on the immune system. 1998 J. Med. Chem. pmid:9484513
Simon CG and Gear AR Membrane-destabilizing properties of C2-ceramide may be responsible for its ability to inhibit platelet aggregation. 1998 Biochemistry pmid:9485333
Lauricella M et al. Increased cyclin E level in retinoblastoma cells during programmed cell death. 1998 Cell. Mol. Biol. (Noisy-le-grand) pmid:9874510
Summers SA et al. Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. 1998 Mol. Cell. Biol. pmid:9710629
Hartfield PJ et al. Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells. 1998 J. Neurochem. pmid:9648862
Zhang J et al. Regulation of membrane release in apoptosis. 1998 Biochem. J. pmid:9716508
Patel M Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic. 1998 J. Neurochem. pmid:9721731
Galadari S et al. Purification and characterization of ceramide-activated protein phosphatases. 1998 Biochemistry pmid:9698369
Hershberger PA et al. In vitro thymocyte maturation is associated with reduced cellular susceptibility to Fas-mediated apoptosis. 1998 Cell. Immunol. pmid:9636691