N-acetylsphingosine

N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.

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Introduction

To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with N-acetylsphingosine?

N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine

MeSH term MeSH ID Detail
Insulin Resistance D007333 99 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Retinoblastoma D012175 12 associated lipids
Helicobacter Infections D016481 21 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Eye Abnormalities D005124 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with N-acetylsphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with N-acetylsphingosine?

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What functions are associated with N-acetylsphingosine?


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What lipids are associated with N-acetylsphingosine?

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What genes are associated with N-acetylsphingosine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with N-acetylsphingosine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with N-acetylsphingosine

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Authors Title Published Journal PubMed Link
Lee TC et al. Biosynthesis of N-acetylsphingosine by platelet-activating factor: sphingosine CoA-independent transacetylase in HL-60 cels. 1996 J. Biol. Chem. pmid:8550561
Cabrero A et al. Increased reactive oxygen species production down-regulates peroxisome proliferator-activated alpha pathway in C2C12 skeletal muscle cells. 2002 J. Biol. Chem. pmid:11792699
Montes LR et al. Membrane restructuring via ceramide results in enhanced solute efflux. 2002 J. Biol. Chem. pmid:11796726
Xin M and Deng X Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation. 2006 J. Biol. Chem. pmid:16679323
Chiu TT et al. Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance. 2013 J. Biol. Chem. pmid:23640896
Abe A et al. A novel enzyme that catalyzes the esterification of N-acetylsphingosine. Metabolism of C2-ceramides. 1996 J. Biol. Chem. pmid:8662981
Jones MJ and Murray AW Evidence that ceramide selectively inhibits protein kinase C-alpha translocation and modulates bradykinin activation of phospholipase D. 1995 J. Biol. Chem. pmid:7890607
Sawai H et al. Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells. 1995 J. Biol. Chem. pmid:7592995
Gill ZP et al. Insulin-like growth factor-binding protein (IGFBP-3) predisposes breast cancer cells to programmed cell death in a non-IGF-dependent manner. 1997 J. Biol. Chem. pmid:9325280
Reunanen N et al. Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathways. 1998 J. Biol. Chem. pmid:9478967
Kondo T et al. Suppression of heat shock protein-70 by ceramide in heat shock-induced HL-60 cell apoptosis. 2000 J. Biol. Chem. pmid:10722733
Gudz TI et al. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. 1997 J. Biol. Chem. pmid:9305864
Boland MP and O'Neill LA Ceramide activates NFkappaB by inducing the processing of p105. 1998 J. Biol. Chem. pmid:9624136
Zhou H et al. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. 1998 J. Biol. Chem. pmid:9632728
Mallick S et al. Human placental lipid induces mitogenesis and melanogenesis in B16F10 melanoma cells. 2002 J. Biosci. pmid:12089473
Jaiswal AS and Narayan S Reduced levels of the adenomatous polyposis coli (APC) protein are associated with ceramide-induced apoptosis of colon cancer cells. 2004 J. Cancer Res. Clin. Oncol. pmid:15340841
Olivera A et al. Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. 1999 J. Cell Biol. pmid:10545499
Rapizzi E et al. Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria. 2002 J. Cell Biol. pmid:12438411
Zhou H et al. Akt regulates cell survival and apoptosis at a postmitochondrial level. 2000 J. Cell Biol. pmid:11062251
Todaro M et al. High levels of exogenous C2-ceramide promote morphological and biochemical evidences of necrotic features in thyroid follicular cells. 2002 J. Cell. Biochem. pmid:12112027
Hughes PJ et al. Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. 2006 J. Cell. Biochem. pmid:16178010
Woessmann W et al. An essential role for mitogen-activated protein kinases, ERKs, in preventing heat-induced cell death. 1999 J. Cell. Biochem. pmid:10440934
Pilane CM and LaBelle EF NO induced apoptosis of vascular smooth muscle cells accompanied by ceramide increase. 2004 J. Cell. Physiol. pmid:15040013
Meadows KA et al. Tumor necrosis factor-alpha-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts. 2000 J. Cell. Physiol. pmid:10797307
Chien CC et al. Activation of telomerase and cyclooxygenase-2 in PDGF and FGF inhibition of C2-ceramide-induced apoptosis. 2009 J. Cell. Physiol. pmid:18932216
Kim DK et al. Adaptive concentrations of hydrogen peroxide suppress cell death by blocking the activation of SAPK/JNK pathway. 2001 J. Cell. Sci. pmid:11739664
Wang XQ et al. Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress. 2003 J. Cell. Sci. pmid:12679386
Fukunaga T et al. Implication of sphingolipid metabolism in the stability of the Golgi apparatus. 2000 J. Cell. Sci. pmid:10954427
Furuya K et al. Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia. 2001 J. Cereb. Blood Flow Metab. pmid:11295877
Chen Y et al. The protective effect of ceramide in immature rat brain hypoxia-ischemia involves up-regulation of bcl-2 and reduction of TUNEL-positive cells. 2001 J. Cereb. Blood Flow Metab. pmid:11149666
Muriel MP et al. Mitochondrial free calcium levels (Rhod-2 fluorescence) and ultrastructural alterations in neuronally differentiated PC12 cells during ceramide-dependent cell death. 2000 J. Comp. Neurol. pmid:10982470
Han WS et al. Effects of C2-ceramide on the Malme-3M melanoma cell line. 2002 J. Dermatol. Sci. pmid:12354415
MacRae VE et al. Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent. 2006 J. Endocrinol. pmid:17088406
Koide N et al. C2-ceramide inhibits LPS-induced nitric oxide production in RAW 264.7 macrophage cells through down-regulating the activation of Akt. 2003 J. Endotoxin Res. pmid:12803880
Frago LM et al. Short-chain ceramide regulates hepatic methionine adenosyltransferase expression. 2001 J. Hepatol. pmid:11281546
Hsu YW et al. Ceramide inhibits lipopolysaccharide-mediated nitric oxide synthase and cyclooxygenase-2 induction in macrophages: effects on protein kinases and transcription factors. 2001 J. Immunol. pmid:11313375
Menné C et al. Ceramide-induced TCR up-regulation. 2000 J. Immunol. pmid:10975817
Yeh MW et al. Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l -cysteine. 2000 J. Immunol. pmid:10754324
Flores I et al. Dual role of ceramide in the control of apoptosis following IL-2 withdrawal. 1998 J. Immunol. pmid:9531315
Lakics V and Vogel SN Lipopolysaccharide and ceramide use divergent signaling pathways to induce cell death in murine macrophages. 1998 J. Immunol. pmid:9725248
Lian JP et al. Products of sphingolipid catabolism block activation of the p21-activated protein kinases in neutrophils. 1998 J. Immunol. pmid:9780215
Bulanova E et al. The IL-15R alpha chain signals through association with Syk in human B cells. 2001 J. Immunol. pmid:11714793
Ragg SJ et al. The mitogen-activated protein kinase pathway inhibits ceramide-induced terminal differentiation of a human monoblastic leukemia cell line, U937. 1998 J. Immunol. pmid:9686602
Fernandez S et al. Inhibition of IL-10 receptor function in alveolar macrophages by Toll-like receptor agonists. 2004 J. Immunol. pmid:14764735
Marques M et al. Identification of platelet-activating factor acetylhydrolase II in human skin. 2002 J. Invest. Dermatol. pmid:12406338
Iwasaki-Bessho Y et al. Decreased phospholipase D (PLD) activity in ceramide-induced apoptosis of human keratinocyte cell line HaCaT. 1998 J. Invest. Dermatol. pmid:9540978
Mansfield PJ et al. Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b(558) by gelatinase-granule release. 2002 J. Lab. Clin. Med. pmid:12080323
Ichinose Y et al. Apoptosis induction in synovial fibroblasts by ceramide: in vitro and in vivo effects. 1998 J. Lab. Clin. Med. pmid:9605105
Hida A et al. Nitric oxide acts on the mitochondria and protects human endothelial cells from apoptosis. 2004 J. Lab. Clin. Med. pmid:15454884
Knapp KM and English BK Ceramide-mediated stimulation of inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation in murine macrophages requires tyrosine kinase activity. 2000 J. Leukoc. Biol. pmid:10811015