| MeSH term | MeSH ID | Detail |
|---|---|---|
| Insulin Resistance | D007333 | 99 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Retinoblastoma | D012175 | 12 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Eye Abnormalities | D005124 | 7 associated lipids |
N-acetylsphingosine
N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
Cross Reference
Introduction
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with N-acetylsphingosine?
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
PubChem Associated disorders and diseases
What pathways are associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with N-acetylsphingosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with N-acetylsphingosine?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with N-acetylsphingosine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Abe A et al. | The acylation of lipophilic alcohols by lysosomal phospholipase A2. | 2007 | J. Lipid Res. | pmid:17626977 |
| Ogiso H et al. | Analysis of lipid-composition changes in plasma membrane microdomains. | 2015 | J. Lipid Res. | pmid:26116739 |
| Giltiay NV et al. | Ceramide- and ERK-dependent pathway for the activation of CCAAT/enhancer binding protein by interleukin-1beta in hepatocytes. | 2005 | J. Lipid Res. | pmid:16106045 |
| Ghering AB and Davidson WS | Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I. | 2006 | J. Lipid Res. | pmid:16990644 |
| Klapisz E et al. | Sphingolipids and cholesterol modulate membrane susceptibility to cytosolic phospholipase A(2). | 2000 | J. Lipid Res. | pmid:11013311 |
| Abe A et al. | Preferential hydrolysis of truncated oxidized glycerophospholipids by lysosomal phospholipase A2. | 2017 | J. Lipid Res. | pmid:27993948 |
| Macchia M et al. | Design, synthesis, and characterization of the antitumor activity of novel ceramide analogues. | 2001 | J. Med. Chem. | pmid:11689086 |
| Sakai T et al. | Effects of alpha- and beta-galactosylated C2-ceramides on the immune system. | 1998 | J. Med. Chem. | pmid:9484513 |
| Arboleda G et al. | Metabolic activity: a novel indicator of neuronal survival in the murine dopaminergic cell line CAD. | 2005 | J. Mol. Neurosci. | pmid:16055947 |
| Sánchez-Mora RM et al. | PINK1 overexpression protects against C2-ceramide-induced CAD cell death through the PI3K/AKT pathway. | 2012 | J. Mol. Neurosci. | pmid:22212487 |
| Falluel-Morel A et al. | Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and PACAP through a MAP-kinase-dependent mechanism in cerebellar granule cells. | 2004 | J. Neurochem. | pmid:15569266 |
| Blázquez C et al. | The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme. | 1999 | J. Neurochem. | pmid:10098887 |
| Aubert N et al. | PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway: involvement of c-Fos in PACAP-induced Bcl-2 expression. | 2006 | J. Neurochem. | pmid:17026529 |
| Poppe M et al. | Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression. | 2002 | J. Neurochem. | pmid:12153473 |
| Chen S et al. | Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes. | 2006 | J. Neurochem. | pmid:16524368 |
| Sabirzhanov B et al. | Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis. | 2012 | J. Neurochem. | pmid:22909049 |
| Darios F et al. | Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death. | 2003 | J. Neurochem. | pmid:12562509 |
| Schultz A and Larsson C | Ceramide influences neurite outgrowth and neuroblastoma cell apoptosis regulated by novel protein kinase C isoforms. | 2004 | J. Neurochem. | pmid:15189345 |
| Wiesner DA and Dawson G | Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway. | 1996 | J. Neurochem. | pmid:8627293 |
| Xie H and Johnson GV | Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I. | 1997 | J. Neurochem. | pmid:9282924 |
| Rossner S et al. | p75 and TrkA receptor signaling independently regulate amyloid precursor protein mRNA expression, isoform composition, and protein secretion in PC12 cells. | 1998 | J. Neurochem. | pmid:9681467 |
| Dawson G et al. | Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death. | 2004 | J. Neurochem. | pmid:15189346 |
| Edsall LC et al. | Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. | 2001 | J. Neurochem. | pmid:11238741 |
| Pascual M et al. | Ceramide pathways modulate ethanol-induced cell death in astrocytes. | 2003 | J. Neurochem. | pmid:14713309 |
| Hartfield PJ et al. | Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells. | 1998 | J. Neurochem. | pmid:9648862 |
| Patel M | Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic. | 1998 | J. Neurochem. | pmid:9721731 |
| MacPhee I and Barker PA | Extended ceramide exposure activates the trkA receptor by increasing receptor homodimer formation. | 1999 | J. Neurochem. | pmid:10098845 |
| Li R and Reiser G | Phosphorylation of Ser45 and Ser59 of αB-crystallin and p38/extracellular regulated kinase activity determine αB-crystallin-mediated protection of rat brain astrocytes from C2-ceramide- and staurosporine-induced cell death. | 2011 | J. Neurochem. | pmid:21615407 |
| Cho S and Dawson G | Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells. | 2000 | J. Neurochem. | pmid:10737604 |
| Li R et al. | Alpha A-crystallin and alpha B-crystallin, newly identified interaction proteins of protease-activated receptor-2, rescue astrocytes from C2-ceramide- and staurosporine-induced cell death. | 2009 | J. Neurochem. | pmid:19558454 |
| Pahan K et al. | Induction of the manganese superoxide dismutase gene by sphingomyelinase and ceramide. | 1999 | J. Neurochem. | pmid:10428046 |
| Yoshimura S et al. | Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death. | 1999 | J. Neurochem. | pmid:10428064 |
| Sée V et al. | C2-ceramide and reactive oxygen species inhibit pituitary adenylate cyclase activating polypeptide (PACAP)-induced cyclic-AMP-dependent signalling pathway. | 2001 | J. Neurochem. | pmid:11158249 |
| Luther JA et al. | Neurotrophins regulate cholinergic synaptic transmission in cultured rat sympathetic neurons through a p75-dependent mechanism. | 2013 | J. Neurophysiol. | pmid:23114219 |
| Xiao Q et al. | Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia. | 2012 | J. Neurosci. | pmid:23015448 |
| Lobner D | Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis? | 2000 | J. Neurosci. Methods | pmid:10720679 |
| Miñano A et al. | C2-ceramide mediates cerebellar granule cells apoptosis by activation of caspases-2, -9, and -3. | 2008 | J. Neurosci. Res. | pmid:18311838 |
| Goswami R et al. | Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines. | 2005 | J. Neurosci. Res. | pmid:15968641 |
| Toman RE et al. | Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis. | 2002 | J. Neurosci. Res. | pmid:12111862 |
| Kimura M et al. | Release of plasminogen activator inhibitor-1 from human astrocytes is regulated by intracellular ceramide. | 2000 | J. Neurosci. Res. | pmid:11107162 |
| Keane RW et al. | Activation of CPP32 during apoptosis of neurons and astrocytes. | 1997 | J. Neurosci. Res. | pmid:9130145 |
| Mattson MP et al. | Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. | 1997 | J. Neurosci. Res. | pmid:9335256 |
| Hatano M et al. | Enhancement of C2-ceramide antitumor activity by small interfering RNA on X chromosome-linked inhibitor of apoptosis protein in resistant human glioma cells. | 2004 | J. Neurosurg. | pmid:15255262 |
| Hunsperger EA and Wilcox CL | Caspase-3-dependent reactivation of latent herpes simplex virus type 1 in sensory neuronal cultures. | 2003 | J. Neurovirol. | pmid:12775421 |
| Lu CY et al. | Docosahexaenoic acid down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the sphingomyelinase/ceramide pathway. | 2010 | J. Nutr. Biochem. | pmid:19427778 |
| Zhang YH et al. | Ceramide, a putative second messenger for nerve growth factor, modulates the TTX-resistant Na(+) current and delayed rectifier K(+) current in rat sensory neurons. | 2002 | J. Physiol. (Lond.) | pmid:12381813 |
| Wang Y et al. | Acid sphingomyelinase mediates 50-Hz magnetic field-induced EGF receptor clustering on lipid raft. | 2016 | J. Recept. Signal Transduct. Res. | pmid:26915736 |
| Murase T et al. | Ceramide enhances acrosomal exocytosis triggered by calcium and the calcium ionophore A23187 in boar spermatozoa. | 2004 | J. Reprod. Dev. | pmid:15647619 |
| Zhang J et al. | Impaired Fas-induced apoptosis of T lymphocytes in patients with abdominal aortic aneurysms. | 2007 | J. Vasc. Surg. | pmid:17350784 |
| Hayashi M et al. | High sensitivity of fibroblast cell lines derived from LEC rats to heat treatment. | 2004 | J. Vet. Med. Sci. | pmid:15528845 |