| MeSH term | MeSH ID | Detail |
|---|---|---|
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Retinoblastoma | D012175 | 12 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Neuronal Ceroid-Lipofuscinoses | D009472 | 5 associated lipids |
N-acetylsphingosine
N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
Cross Reference
Introduction
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with N-acetylsphingosine?
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
PubChem Associated disorders and diseases
What pathways are associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with N-acetylsphingosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with N-acetylsphingosine?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with N-acetylsphingosine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Perks CM et al. | Activation of integrin and ceramide signalling pathways can inhibit the mitogenic effect of insulin-like growth factor I (IGF-I) in human breast cancer cell lines. | 1999 | Br. J. Cancer | pmid:10070857 |
| Shinpo K et al. | Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons. | 1999 | Brain Res. | pmid:10082875 |
| Medvedev AE et al. | Limited role of ceramide in lipopolysaccharide-mediated mitogen-activated protein kinase activation, transcription factor induction, and cytokine release. | 1999 | J. Biol. Chem. | pmid:10092612 |
| Mahajan S et al. | Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamide]. | 1999 | J. Biol. Chem. | pmid:10092645 |
| MacPhee I and Barker PA | Extended ceramide exposure activates the trkA receptor by increasing receptor homodimer formation. | 1999 | J. Neurochem. | pmid:10098845 |
| Blázquez C et al. | The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme. | 1999 | J. Neurochem. | pmid:10098887 |
| Kovács P et al. | Effect of C2 ceramide on the inositol phospholipid metabolism (uptake of 32P, 3H-serine and 3H-palmitic acid) and apoptosis-related morphological changes in Tetrahymena. | 1999 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:10190048 |
| Puranam KL et al. | CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide. | 1999 | Mol. Genet. Metab. | pmid:10191118 |
| Su X et al. | Differential activation of phosphoinositide 3-kinase by endothelin and ceramide in colonic smooth muscle cells. | 1999 | Am. J. Physiol. | pmid:10198327 |
| Tolleson WH et al. | Fumonisin B1 induces apoptosis in cultured human keratinocytes through sphinganine accumulation and ceramide depletion. | 1999 | Int. J. Oncol. | pmid:10200332 |
| Alesse E et al. | The growth arrest and downregulation of c-myc transcription induced by ceramide are related events dependent on p21 induction, Rb underphosphorylation and E2F sequestering. | 1998 | Cell Death Differ. | pmid:10200487 |
| Lee BR and Um HD | Hydrogen peroxide suppresses U937 cell death by two different mechanisms depending on its concentration. | 1999 | Exp. Cell Res. | pmid:10222135 |
| Herr I et al. | FK506 prevents stroke-induced generation of ceramide and apoptosis signaling. | 1999 | Brain Res. | pmid:10224298 |
| Watton SJ and Downward J | Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction. | 1999 | Curr. Biol. | pmid:10226029 |
| Mengubas K et al. | Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism. | 1999 | Oncogene | pmid:10229201 |
| Kim YH and Kim SS | Increase of MnSOD expression and decrease of JNK activity determine the TNF sensitivity in bcl2-transfected L929 cells. | 1999 | Cytokine | pmid:10328866 |
| Mengubas K et al. | Killing of T lymphocytes by synthetic ceramide is by a nonapoptotic mechanism and is abrogated following mitogenic activation. | 1999 | Exp. Cell Res. | pmid:10328959 |
| Taniwaki T et al. | Ceramide induces apoptosis to immature cerebellar granule cells in culture. | 1999 | Neurochem. Res. | pmid:10344598 |
| Masamune A et al. | Helicobacter pylori-dependent ceramide production may mediate increased interleukin 8 expression in human gastric cancer cell lines. | 1999 | Gastroenterology | pmid:10348816 |