| MeSH term | MeSH ID | Detail |
|---|---|---|
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Retinoblastoma | D012175 | 12 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Neuronal Ceroid-Lipofuscinoses | D009472 | 5 associated lipids |
N-acetylsphingosine
N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
Cross Reference
Introduction
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with N-acetylsphingosine?
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
PubChem Associated disorders and diseases
What pathways are associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with N-acetylsphingosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with N-acetylsphingosine?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with N-acetylsphingosine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang XQ et al. | Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress. | 2003 | J. Cell. Sci. | pmid:12679386 |
| Itoh M et al. | Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia. | 2003 | Clin. Cancer Res. | pmid:12538495 |
| Darios F et al. | Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death. | 2003 | J. Neurochem. | pmid:12562509 |
| Ito M | Insulin or bFGF and C2 ceramide increase newborn rat retinal ganglion cell survival rate. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12565900 |
| Cho YH et al. | Potentiation of lipopolysaccharide-inducible cyclooxygenase 2 expression by C2-ceramide via c-Jun N-terminal kinase-mediated activation of CCAAT/enhancer binding protein beta in macrophages. | 2003 | Mol. Pharmacol. | pmid:12606757 |
| Upham BL et al. | Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis. | 2003 | Cancer Lett. | pmid:12609706 |
| Mikati MA et al. | Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms. | 2003 | Epilepsia | pmid:12614382 |
| Prinetti A et al. | Altered sphingolipid metabolism in N-(4-hydroxyphenyl)-retinamide-resistant A2780 human ovarian carcinoma cells. | 2003 | J. Biol. Chem. | pmid:12486134 |
| Latorre E et al. | Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide. | 2003 | Eur. J. Biochem. | pmid:12492473 |
| Gentil B et al. | Commitment to apoptosis by ceramides depends on mitochondrial respiratory function, cytochrome c release and caspase-3 activation in Hep-G2 cells. | 2003 | Mol. Cell. Biochem. | pmid:14674699 |
| Pascual M et al. | Ceramide pathways modulate ethanol-induced cell death in astrocytes. | 2003 | J. Neurochem. | pmid:14713309 |
| Bourbon NA et al. | Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest. | 2002 | J. Biol. Chem. | pmid:11723139 |
| Calcerrada MC et al. | Involvement of phosphatidylinositol 3-kinase in nuclear translocation of protein kinase C zeta induced by C2-ceramide in rat hepatocytes. | 2002 | FEBS Lett. | pmid:11943182 |
| Bitar KN | HSP27 phosphorylation and interaction with actin-myosin in smooth muscle contraction. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11960785 |
| Perks CM et al. | A non-IGF binding mutant of IGFBP-3 modulates cell function in breast epithelial cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12074574 |
| Perks CM et al. | Effects of a non-IGF binding mutant of IGFBP-5 on cell death in human breast cancer cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12074575 |
| Mansfield PJ et al. | Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b(558) by gelatinase-granule release. | 2002 | J. Lab. Clin. Med. | pmid:12080323 |
| Kumar Mangalam A et al. | Gold sodium thiomalate (GSTM) inhibits lipopolysaccharide stimulated tumor necrosis factor-alpha through ceramide pathway. | 2002 | Cell. Immunol. | pmid:12473262 |
| Movsesyan VA et al. | Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12437970 |
| Rapizzi E et al. | Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria. | 2002 | J. Cell Biol. | pmid:12438411 |