| MeSH term | MeSH ID | Detail |
|---|---|---|
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Retinoblastoma | D012175 | 12 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Neuronal Ceroid-Lipofuscinoses | D009472 | 5 associated lipids |
N-acetylsphingosine
N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
Cross Reference
Introduction
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with N-acetylsphingosine?
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
PubChem Associated disorders and diseases
What pathways are associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with N-acetylsphingosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with N-acetylsphingosine?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with N-acetylsphingosine?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with N-acetylsphingosine
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pruschy M et al. | Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells. | 1999 | Br. J. Cancer | pmid:10360645 |
| Hisano N et al. | Induction and suppression of endothelial cell apoptosis by sphingolipids: a possible in vitro model for cell-cell interactions between platelets and endothelial cells. | 1999 | Blood | pmid:10361127 |
| Li PL et al. | Effect of ceramide on KCa channel activity and vascular tone in coronary arteries. | 1999 | Hypertension | pmid:10373230 |
| Stewart CE et al. | Increased, not decreased activation of the insulin-like growth factor (IGF) receptor signalling pathway during ceramide-induced apoptosis. | 1999 | Growth Horm. IGF Res. | pmid:10373346 |
| Jones BE et al. | Ceramide induces caspase-independent apoptosis in rat hepatocytes sensitized by inhibition of RNA synthesis. | 1999 | Hepatology | pmid:10385659 |
| Dallalio G et al. | Inhibition of human erythroid colony formation by ceramide. | 1999 | Exp. Hematol. | pmid:10390188 |
| Shinoda J et al. | Effect of ceramide on interleukin-6 synthesis in osteoblast-like cells. | 1999 | Cell. Signal. | pmid:10400316 |
| Buisson-Legendre N et al. | Involvement of the 92-kDa gelatinase (matrix metalloproteinase-9) in the ceramide-mediated inhibition of human keratinocyte growth. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10403818 |
| Brindley DN et al. | Tumor necrosis factor-alpha and ceramides in insulin resistance. | 1999 | Lipids | pmid:10419100 |
| Pahan K et al. | Induction of the manganese superoxide dismutase gene by sphingomyelinase and ceramide. | 1999 | J. Neurochem. | pmid:10428046 |
| Yoshimura S et al. | Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death. | 1999 | J. Neurochem. | pmid:10428064 |
| Scaffidi C et al. | Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. | 1999 | J. Biol. Chem. | pmid:10428830 |
| Woessmann W et al. | An essential role for mitogen-activated protein kinases, ERKs, in preventing heat-induced cell death. | 1999 | J. Cell. Biochem. | pmid:10440934 |
| Maile LA et al. | The role of cell surface attachment and proteolysis in the insulin-like growth factor (IGF)-independent effects of IGF-binding protein-3 on apoptosis in breast epithelial cells. | 1999 | Endocrinology | pmid:10465274 |
| Belaud-Rotureau MA et al. | Ceramide-induced apoptosis occurs independently of caspases and is decreased by leupeptin. | 1999 | Cell Death Differ. | pmid:10467353 |
| Askew DJ et al. | Characterization of Apt- cell lines exhibiting cross-resistance to glucocorticoid- and Fas-mediated apoptosis. | 1999 | Cell Death Differ. | pmid:10467354 |
| Pirianov G et al. | Potentiation by vitamin D analogs of TNFalpha and ceramide-induced apoptosis in MCF-7 cells is associated with activation of cytosolic phospholipase A2. | 1999 | Cell Death Differ. | pmid:10510471 |
| Meroni SB et al. | Effect of N-acetylsphingosine (C2) and the ceramidase inhibitor (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol on the regulation of Sertoli cell function. | 1999 Sep-Oct | J. Androl. | pmid:10520574 |
| Olivera A et al. | Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. | 1999 | J. Cell Biol. | pmid:10545499 |
| Park BJ et al. | Effect of ceramide on apoptosis and phospholipase D activity in FRTL-5 thyroid cells. | 1999 | Exp. Mol. Med. | pmid:10551263 |