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The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosis. |
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Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release. |
2000 |
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Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells. |
2000 |
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Ceramide-mediated stimulation of inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation in murine macrophages requires tyrosine kinase activity. |
2000 |
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Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. |
2000 |
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Tumor necrosis factor-alpha-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts. |
2000 |
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Ceramides that mediate apoptosis reduce glucose uptake and transporter affinity for glucose in human leukaemic cell lines but not in neutrophils. |
2000 |
Pharmacol. Toxicol. |
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Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l -cysteine. |
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2000 |
Cell Motil. Cytoskeleton |
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Regulation of rheumatoid synovial cell growth by ceramide. |
2000 |
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2000 |
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2000 |
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2000 |
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Hepatocyte growth factor protects gastric epithelial cells against ceramide-induced apoptosis through induction of cyclooxygenase-2. |
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2000 Apr-Jun |
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2001 |
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2001 |
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TNFalpha enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation. |
2001 |
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Tumor necrosis factor-alpha induces stress fiber formation through ceramide production: role of sphingosine kinase. |
2001 |
Mol. Biol. Cell |
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Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids. |
2001 |
Cancer Res. |
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Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis. |
2001 |
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C2-ceramide signaling in glioma cells: synergistic enhancement of CD95-mediated, caspase-dependent apoptosis. |
2001 |
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Propagation of the apoptotic signal by mitochondrial waves. |
2001 |
EMBO J. |
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Uncoupling protein-3 mRNA up-regulation in C2C12 myotubes after etomoxir treatment. |
2001 |
Biochim. Biophys. Acta |
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Synergistic effect of interleukin-1alpha and ceramide analogue on production of prostaglandin E2 and F2alpha by endometrial stromal cells. |
2001 |
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Tumor necrosis factor-alpha, sphingomyelinase and ceramides activate tyrosine kinase, p21Ras and phosphatidylinositol 3-kinase: implications for glucose transport and insulin resistance. |
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Adaptive concentrations of hydrogen peroxide suppress cell death by blocking the activation of SAPK/JNK pathway. |
2001 |
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2001 |
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Design, synthesis, and characterization of the antitumor activity of novel ceramide analogues. |
2001 |
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Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia. |
2001 |
J. Cereb. Blood Flow Metab. |
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Ceramide reduces endothelium-dependent vasodilation by increasing superoxide production in small bovine coronary arteries. |
2001 |
Circ. Res. |
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Short-chain ceramide regulates hepatic methionine adenosyltransferase expression. |
2001 |
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Loss of cyclin A and G1-cell cycle arrest are a prerequisite of ceramide-induced toxicity in human arterial endothelial cells. |
2001 |
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Ceramide inhibits cell proliferation through Akt/PKB inactivation and decreases melanin synthesis in Mel-Ab cells. |
2001 |
Pigment Cell Res. |
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2001 |
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2001 |
EMBO J. |
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Effects of ceramide on aggrecanase activity in rabbit articular cartilage. |
2001 |
Biochem. Biophys. Res. Commun. |
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2001 |
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Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. |
2001 |
Diabetologia |
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Caspase-resistant vimentin suppresses apoptosis after photodynamic treatment with a silicon phthalocyanine in Jurkat cells. |
2001 |
Arch. Biochem. Biophys. |
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Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation. |
2001 |
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Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases. |
2001 |
Brain Res. |
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The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. |
2001 |
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2001 |
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NF-kappa B mediates the adaptation of human U937 cells to hydrogen peroxide. |
2001 |
Free Radic. Biol. Med. |
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Ceramide inhibition of mammalian phospholipase D1 and D2 activities is antagonized by phosphatidylinositol 4,5-bisphosphate. |
2001 |
Biochemistry |
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2001 |
Eur. J. Paediatr. Neurol. |
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Cell cycle arrest of hematopoietic cell lines after treatment with ceramide is commonly associated with retinoblastoma activation. |
2001 |
Cytometry |
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The protective effect of ceramide in immature rat brain hypoxia-ischemia involves up-regulation of bcl-2 and reduction of TUNEL-positive cells. |
2001 |
J. Cereb. Blood Flow Metab. |
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The IL-15R alpha chain signals through association with Syk in human B cells. |
2001 |
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2001 |
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2001 |
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Sphingomyelinase but not ceramide induces nitric oxide synthase expression in rat brain microglia. |
2001 |
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Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation. |
2001 |
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Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells. |
2001 |
Mol. Pharmacol. |
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Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. |
2001 |
Cancer Res. |
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t-SNARE dephosphorylation promotes SNARE assembly and exocytosis in yeast. |
2001 |
EMBO J. |
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C2-ceramide and reactive oxygen species inhibit pituitary adenylate cyclase activating polypeptide (PACAP)-induced cyclic-AMP-dependent signalling pathway. |
2001 |
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Involvement of wild-type p53 in radiation-induced c-Jun N-terminal kinase activation in human thyroid cells. |
2001 Jul-Aug |
Anticancer Res. |
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[Relationship between the induction of MDR1, a multidrug resistance gene in tumor cells, and apoptosis]. |
2001 Jul-Aug |
Ontogenez |
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Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest. |
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Ceramide and sphingosine rapidly induce apoptosis of murine mast cells supported by interleukin-3 and stem cell factor. |
2002 |
Exp. Hematol. |
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The synthesis and biological characterization of a ceramide library. |
2002 |
J. Am. Chem. Soc. |
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C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes. |
2002 |
Diabetes |
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Vesnarinone causes oxidative damage by inhibiting catalase function through ceramide action in myeloid cell apoptosis. |
2002 |
Mol. Pharmacol. |
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Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. |
2002 |
Oncogene |
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Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A. |
2002 |
Cell. Signal. |
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Kralik SF et al. |
Ceramide and glucosamine antagonism of alternate signaling pathways regulating insulin- and osmotic shock-induced glucose transporter 4 translocation. |
2002 |
Endocrinology |
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Cell-permeable ceramides preferentially inhibit coated vesicle formation and exocytosis in Chinese hamster ovary compared with Madin-Darby canine kidney cells by preventing the membrane association of ADP-ribosylation factor. |
2002 |
Biochem. J. |
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Ceramide does not act as a general second messenger for ultraviolet-induced apoptosis. |
2002 |
Oncogene |
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Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D. |
2002 |
Blood |
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Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status. |
2002 |
Arch. Biochem. Biophys. |
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Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways. |
2002 |
Gastroenterology |
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Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis. |
2002 |
J. Neurosci. Res. |
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High levels of exogenous C2-ceramide promote morphological and biochemical evidences of necrotic features in thyroid follicular cells. |
2002 |
J. Cell. Biochem. |
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Mitochondrial cytochrome c release precedes transmembrane depolarisation and caspase-3 activation during ceramide-induced apoptosis of Jurkat T cells. |
2002 |
Apoptosis |
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Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway. |
2002 |
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Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression. |
2002 |
J. Neurochem. |
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Phosphorylation of cardiac protein kinase B is regulated by palmitate. |
2002 |
Am. J. Physiol. Heart Circ. Physiol. |
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Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays. |
2002 |
Genome Biol. |
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t-SNARE phosphorylation regulates endocytosis in yeast. |
2002 |
Mol. Biol. Cell |
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Decreased activity and enhanced nuclear export of CCAAT-enhancer-binding protein beta during inhibition of adipogenesis by ceramide. |
2002 |
Biochem. J. |
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Effects of C2-ceramide on the Malme-3M melanoma cell line. |
2002 |
J. Dermatol. Sci. |
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Zhang YH et al. |
Ceramide, a putative second messenger for nerve growth factor, modulates the TTX-resistant Na(+) current and delayed rectifier K(+) current in rat sensory neurons. |
2002 |
J. Physiol. (Lond.) |
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Marques M et al. |
Identification of platelet-activating factor acetylhydrolase II in human skin. |
2002 |
J. Invest. Dermatol. |
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Slight impairment of Na+,K+-ATPase synergistically aggravates ceramide- and beta-amyloid-induced apoptosis in cortical neurons. |
2002 |
Brain Res. |
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C(2)-ceramide-induced circular smooth muscle cell contraction involves PKC-epsilon and p44/p42 MAPK activation in cat oesophagus. Mitogen-activated protein kinase. |
2002 |
Cell. Signal. |
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Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells. |
2002 |
Biol. Chem. |
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Inhibition of CTP:phosphocholine cytidylyltransferase by C(2)-ceramide and its relationship to apoptosis. |
2002 |
Mol. Pharmacol. |
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Colligan PB et al. |
Ceramide attenuates high glucose-induced cardiac contractile abnormalities in cultured adult rat ventricular myocytes. |
2002 |
Cell. Mol. Biol. (Noisy-le-grand) |
pmid:12643441
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Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. |
2002 |
J. Biol. Chem. |
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Kim DS et al. |
Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes. |
2002 |
Cell. Signal. |
pmid:12034359
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Preaux AM et al. |
Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2. |
2002 |
Hepatology |
pmid:12198653
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Mallick S et al. |
Human placental lipid induces mitogenesis and melanogenesis in B16F10 melanoma cells. |
2002 |
J. Biosci. |
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Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide. |
2002 |
Cell. Signal. |
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