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Biochemistry |
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Ceramide inhibits L-type calcium channel currents in rat pinealocytes. |
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Killing of T lymphocytes by synthetic ceramide is by a nonapoptotic mechanism and is abrogated following mitogenic activation. |
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Tumor necrosis factor-alpha and ceramides in insulin resistance. |
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Lipids |
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Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells. |
1999 |
Br. J. Cancer |
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Effect of ceramide on KCa channel activity and vascular tone in coronary arteries. |
1999 |
Hypertension |
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Increased, not decreased activation of the insulin-like growth factor (IGF) receptor signalling pathway during ceramide-induced apoptosis. |
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Involvement of the 92-kDa gelatinase (matrix metalloproteinase-9) in the ceramide-mediated inhibition of human keratinocyte growth. |
1999 |
Biochem. Biophys. Res. Commun. |
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Hydrogen peroxide suppresses U937 cell death by two different mechanisms depending on its concentration. |
1999 |
Exp. Cell Res. |
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Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism. |
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Oncogene |
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Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamide]. |
1999 |
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Extended ceramide exposure activates the trkA receptor by increasing receptor homodimer formation. |
1999 |
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CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide. |
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Mol. Genet. Metab. |
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1999 |
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Effect of ceramide on interleukin-6 synthesis in osteoblast-like cells. |
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Effect of C2 ceramide on the inositol phospholipid metabolism (uptake of 32P, 3H-serine and 3H-palmitic acid) and apoptosis-related morphological changes in Tetrahymena. |
1999 |
Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. |
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The role of cell surface attachment and proteolysis in the insulin-like growth factor (IGF)-independent effects of IGF-binding protein-3 on apoptosis in breast epithelial cells. |
1999 |
Endocrinology |
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Ceramide-induced apoptosis occurs independently of caspases and is decreased by leupeptin. |
1999 |
Cell Death Differ. |
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Characterization of Apt- cell lines exhibiting cross-resistance to glucocorticoid- and Fas-mediated apoptosis. |
1999 |
Cell Death Differ. |
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Potentiation by vitamin D analogs of TNFalpha and ceramide-induced apoptosis in MCF-7 cells is associated with activation of cytosolic phospholipase A2. |
1999 |
Cell Death Differ. |
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Effect of ceramide on apoptosis and phospholipase D activity in FRTL-5 thyroid cells. |
1999 |
Exp. Mol. Med. |
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An essential role for mitogen-activated protein kinases, ERKs, in preventing heat-induced cell death. |
1999 |
J. Cell. Biochem. |
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Induction of the manganese superoxide dismutase gene by sphingomyelinase and ceramide. |
1999 |
J. Neurochem. |
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Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death. |
1999 |
J. Neurochem. |
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Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. |
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J. Biol. Chem. |
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Helicobacter pylori-dependent ceramide production may mediate increased interleukin 8 expression in human gastric cancer cell lines. |
1999 |
Gastroenterology |
pmid:10348816
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MacKichan ML and DeFranco AL |
Role of ceramide in lipopolysaccharide (LPS)-induced signaling. LPS increases ceramide rather than acting as a structural homolog. |
1999 |
J. Biol. Chem. |
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Ceramide and cyclic adenosine monophosphate (cAMP) induce cAMP response element binding protein phosphorylation via distinct signaling pathways while having opposite effects on myeloid cell survival. |
1999 |
Blood |
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